2019 American Transplant Congress
Post-Transplant Cancer Following Living Donor HLA-Incompatible Kidney Transplantation
1Johns Hopkins University, Baltimore, MD, 2University of Alabama, Birmingham, AL
*Purpose: Incompatible living donor kidney transplantation (ILDKT) recipients require increased immunosuppression compared to their compatible living donor kidney transplant (CLDKT) counterparts. This continued exposure to…2019 American Transplant Congress
Towards Human Leukocyte Antigen Immunogenicity Assessment at the Individual Patient Level
*Purpose: Allorecognition of donor HLA and induction of humoral alloimmunity is a major cause of graft loss after solid-organ transplantation. Current approaches to study molecular…2019 American Transplant Congress
Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates
*Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…2019 American Transplant Congress
The Effect Of Exclusive Virtual Crossmatch To Allocate Deceased Donor Kidney Transplant On Cold Ischemia Time And Acute Rejection
*Purpose: Virtual crossmatch (VXM) using Luminex single antigen bead has significantly improved prediction of an actual negative crossmatch. A negative crossmatch is typically required for…2019 American Transplant Congress
Center-Level Variation in HLA-Incompatible Living Donor Kidney Transplantation Outcomes
1Johns Hopkins University, Baltimore, MD, 2University of Alabama School of Medicine, Birmingham, AL
*Purpose: Desensitization protocols for HLA-incompatible living donor kidney transplantation (ILDKT) vary across centers. The impact of these variations, as well as other practice variations, on…2019 American Transplant Congress
SIRPα Typing as a Potential Tool for Risk Stratification in Kidney Transplantation
Transplant Immunology Laboratory, Northwestern University, Chicago, IL
*Purpose: To determine if mismatches in the SIRPα receptor, associated with initiate innate alloresponses in animal models, may impact human kidney transplantation outcome.*Methods: To avoid…2019 American Transplant Congress
Characterization of Intra-Exosomal Cargoes of Circulating Donor Heart Specific Exosomes in Murine Heart Transplantation Model
Department of Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: Exosomes are tissue specific, bilayered, membrane-bound nanoparticles released by many types of cells into bodily fluids including blood and urine. Exosomes carry protein and…2019 American Transplant Congress
A2 To B Kidney Transplants Under Kidney Allocation System: A Prospective Study Of Anti A Titers And Correlation With Outcomes
Vanderbilt University, Nashville, TN
*Purpose: The UNOS KAS system incorporates A2 to B deceased donor kidney transplants (DDKTx) to improve access and reduce disparities in wait times for B…2019 American Transplant Congress
Unifying Interpretation of Molecular HLA Typing Data between the Solid Organ Allocation Match Run and Virtual Crossmatch
*Purpose: Virtual crossmatch compares a transplant candidate’s HLA antibody assay results to the HLA typing of the donor before an organ offer is accepted. While…2018 American Transplant Congress
Can We Expect the “Unexpected”?
Northwestern University, Chicago.
A known, seemingly paradoxical, phenomenon of the HLA system is the high overall degree of homology among different HLA alleles, despite vast polymorphism in the…
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