ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histocompatibility"

  • 2016 American Transplant Congress

    Optimizing CPRAs for Sensitized Kidney Waitlist Candidates: The Devil Is in the KAS Details.

    J. Houp,1 R. Vega,1 B. Lonze,2 N. Desai,2 R. Montgomery,2 A. Jackson.1

    1Medicine, Johns Hopkins University, Baltimore, MD; 2Surgery, Johns Hopkins University, Baltimore, MD.

    The new kidney allocation system (KAS) has increased transplant rates for highly sensitized candidates. We hypothesized that increasing unacceptable antigens to transition candidates from 80-98%…
  • 2016 American Transplant Congress

    Presence of Highly Immunogenic Mismatch Eplets Is Associated with Development of Chronic Active Antibody-Mediated Rejection: A First Report from Japan.

    D. Iwami, K. Morita, H. Sasaki, H. Higuchi, Y. Takada, N. Shinohara.

    Urology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.

    Backgrounds: De novo donor specific antibody (dnDSA) correlates with chronic active antibody-mediated rejection (CAAMR), a major leading cause of graft loss. It will be a…
  • 2016 American Transplant Congress

    Analysis of Intra-Graft Anti-HLA Antibodies Suggests That HLA Sensitization Occurs Long After an Allograft Nephrectomy and Is Not Due to a Release of Anti-HLA Antibodies from the Failed Kidney.

    D. Milongo,1 N. Congy-Jolivet,2 A. Del Bello,1 F. Sallusto,3 L. Esposito,1 L. Rostaing,1 N. Kamar.1

    1Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; 2Department of Immunology, CHU Rangueil, Toulouse, France; 3Department of Urology and Kidney Transplantation, CHU Rangueil, Toulouse, France.

    Background: The mechanism leading to the appearance of anti-HLA antibodies and donor-specific antibodies (DSAs) after an allograft nephrectomy (NTx) is not fully understood. Two mechanisms…
  • 2015 American Transplant Congress

    HLA-Cw Mismatches Are Not Associated With Worse Graft Outcomes After Kidney Transplantation Even in High Levels of Antigen Expression

    M. Askar,1 N. Elfadawy,1,2 S. Flechner,1 K. Abu-Elmagd,1 J. Fung,1 J. Schold.1

    1Cleveland Clinic, Cleveland; 2University of Alexandria, Alexandria, Egypt.

    The HLA-Cw antigens are distinct in having relatively lower expression on the cell surface compared to the other HLA class I loci. Higher HLA Cw…
  • 2015 American Transplant Congress

    Clinical Relevance of C3d-Binding Donor-Specific Antibodies in Late Kidney Allograft Failure

    J. Lan, D. Gjertson, Y. Zheng, DeKAF Investigators, E. Reed, M. Cecka.

    Path, UCLA, LA, CA.

    Background: The objective of this study was to investigate the prognostic value of C3d-binding donor-specific antibodies (DSA) in determining late kidney allograft failure.Methods: 1048 patients…
  • 2015 American Transplant Congress

    Number of Antigen Targets: A Key Parameter for Accurate Flow Cytometry Crossmatch Interpretation of Weak DSA

    L. Hidalgo,1 S. Hasenbank,1 A. Halpin,1 P. Campbell.1,2

    1Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 2Medicine, University of Alberta, Edmonton, AB, Canada.

    BACKGROUND: Flow cytometry crossmatch (FCXM) results are used to assess the safety of a transplant across pre-existing DSA. The number of targets on donor cells…
  • 2015 American Transplant Congress

    Human Hematopoietic Chimeric Cells as a Novel Approach for Tolerance Induction After Transplantation

    E. Bryndza Tfaily,1 J. Cwykiel,1 K. Dastych,2 A. Sklodowska,1 M. Siemionow.1

    1Orthopaedics, University of Illinois at Chicago, Chicago, IL; 2Pathology, University of Illinois at Chicago, Chicago, IL.

    Background: Cellular therapies represent a new promising approach for transplant tolerance induction. One of the methods for immune response modulation in solid organ and vascularized…
  • 2015 American Transplant Congress

    Kidney Paired Donation: National Activity and Perspectives

    T. Dunn,1 S. Fayek,2 C. Marsh,3 P. Abt.4

    1Surgery, University of Minnesota, Minneapolis, MN; 2Surgery, Rush University Medical Center, Chicago, IL; 3Surgery, Scripps Health, La Jolla, CA; 4Surgery, University of Pennsylvania, Philadelphia, PA.

    While utilization of Kidney Paired Donation (KPD) continues to increase, the potential is not fully realized. We surveyed kidney transplant (KTX) professionals to evaluate perceptions…
  • 2015 American Transplant Congress

    Improving the Predictive Value of the Virtual Crossmatch: Is the C1Q Assay Needed?

    A. Colovai,1 C. Savchik,1 P. Masiakos,1 S. Calp-Inal,2 L. Kayler,3 E. Akalin.2

    1Transplant Immunology Laboratory, Montefiore Medical Center, Bronx, NY; 2Nephrology, Montefiore Medical Center, Bronx, NY; 3Surgery, Montefiore Medical Center, Bronx, NY.

    The criteria for reporting unacceptable HLA antigens of renal transplant candidates differ greatly between transplant centers. In the attempt to refine these criteria, the experience…
  • 2015 American Transplant Congress

    HLA-C, KIR Genotypes and KIR Genotype/HLA –C Ligand Combination in Prediction of Early Acute Rejection After Liver Transplantation

    K. Park,1 J. Ryu,1 H. Park,3 Y. Kim,2 E.-J. Oh.2

    1Biomedical Science, Graduate School, The Catholic University of Korea, Seoul, Republic of Korea; 2Laboratory Medicine, Seoul St. Mary's Hospital, the Catholic University of Korea, Seoul, Republic of Korea; 3Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

    Introduction; Interaction of killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen class-I (HLA-I) regulates NK cytotoxicity and function. NK regulation influences on NK/T cell alloreactivity…
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