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Articles tagged "Histocompatibility"

  • 2018 American Transplant Congress

    The Brazilian Epitope Virtual Crossmatch Protocol: A Reliable Tool for Increasing Kidney Allocation among Highly Sensitized Patients

    L. Sousa,1 A. Silva,1 M. Marroquim,1 A. Coelho,1 A. Lima,1 F. Silva,1 C. Carracosa,2 G. Willcox,3 T. Leão,3 B. Correa,3 E. Guimarães,3 G. Maciel,3 J. Andrade,4 A. Andrade,4 R. Neto,4 S. Cavalcante,4 C. Leão,4 F. Cavalcante,5 A. Holanda,5 N. Gomes,6 A. Rego,6 S. Monte.1

    1UFPI, Teresina, PI, Brazil; 2PUC, Curitiba, PR, Brazil; 3HLA Diagnostico, Recife, PE, Brazil; 4IMIP, Recife, PE, Brazil; 5RHP, Recife, PE, Brazil; 6CNCDO, Recife, PE, Brazil.

    Background: In Brazil (BZ), the kidney allocation policy for highly sensitized patients (HS) (PRA ≥ 80%) does not involve prioritization and transplants 10 times less…
  • 2018 American Transplant Congress

    A New Reality: Virtual Crossmatch Can Be Used Successfully as Pre-Transplant Compatibility Testing for Most Deceased Donor Transplants at a High Volume Center

    R. Rajalingam,1 D. Gae,1 Z. Laszik,2 G. Roll,3 M. Tavakol,3 C. Freise,3 D. Adey,4 A. Webber,4 D. Dobi,2 K. Cunniffe,1 G. da Gente,1 N. Ascher,3 P. Stock,3 J. Roberts.3

    1Immunogenetics and Transplantation Laboratory, Dept. of Surgery, UCSF, San Francisco; 2Dept. of Pathology, UCSF, San Francisco; 3Dept. of Surgery, UCSF, San Francisco; 4Dept. of Medicine, UCSF, San Francisco.

    Aim: We developed a reliable virtual crossmatch (VXM) method for use as pre-transplant XM for deceased donor (DD) kidney transplantation (KTx). Here we report the…
  • 2018 American Transplant Congress

    Acute Antibody Mediated Rejection Treatment Impact on Class I and Class II Anti-HLA Antibodies in Pediatric Kidney Transplant Recipients

    E. Kincaide,1,2,3 K. Hitchman,1,3 R. Hall,1,2,3 I. Yamaguchi,3 B. Crowther.1,2,3

    1University Health System, San Antonio, TX; 2College of Pharmacy, Pharmacotherapy Division, The University of Texas at Austin, Austin, TX; 3UT Health San Antonio, San Antonio, TX.

    Purpose: Characterize class I and class II donor specific antibodies (DSA) response to acute antibody mediated rejection (AMR) treatment in pediatric kidney transplant recipients (KTR).Methods:…
  • 2018 American Transplant Congress

    Flow DSA-XM: Better Crossmatch or Just Different Problems?

    P. Kimball, F. McDougan.

    Surgery, VCUHealth Systems, Richmond, VA.

    Background. Despite the positive impact of flow crossmatching(FCXM) upon alloantibody detection, its inability to distinguish anti-Class I from Class II or non-HLA from HLA-antibodies remain…
  • 2017 American Transplant Congress

    Positive Flow Crossmatch After Negative Virtual Crossmatch -A Single Center Experience.

    Q. Xu, S. Leckie.

    Pathology and Lab Medicine, London Health Sciences Center, London, ON, Canada

    Aims: To determine causes of Flow Cytometry crossmatch (FCXM) after a negative virtual crossmatch (VirXM), even with sensitive solid-phase antibody assay and complete HLA typings…
  • 2017 American Transplant Congress

    Using Buccal Swabs for Deceased Organ Donor HLA Typing.

    C. Muse,2 S. Longobardi,1 I. Gimferrer,1 J. Orlowski.2

    1HLA Laboratory, OU Medical Center, Oklahoma City, OK; 2LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK

    Aim: In some cases, getting enough cells from a deceased donor to perform crossmatches and DNA extraction for HLA typing is challenging. Specifically this is…
  • 2017 American Transplant Congress

    Accelerated Rejection of Secondary Third Party Allografts in Older Recipients Is Facilitated by an Augmented Innate Immune Response.

    T. Heinbokel, K. Minami, A. Elkhal, S. Tullius.

    Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Accumulating evidence acknowledges the central relevance of aging and chronic antigen exposure in shaping the balance of innate and adaptive immunity. Here, we assessed whether…
  • 2017 American Transplant Congress

    Harnessing Scientific and Technological Advances to Improve Equity in Kidney Allocation Policies.

    C. Jacquelinet,1 B. Audry,1 C. Antoine,1 C. Suberbielle,2 D. Glotz,2 A. Tambur.3

    1Agence de la Biomedecine, Saint Denis, France; 2Saint Louis Hospital, Paris, France; 3Northwestern University, Chicago

    To increase the likelihood of finding a compatible donor, kidney allocation systems prioritize highly sensitized patients to counterbalance the impact of HLA allo-sensitization and preclude…
  • 2017 American Transplant Congress

    MHC Class II-Peptide Complexes Displayed on Activated T Cells Guide Treg Suppression.

    M. Fryer, S. Junius, S. Germana, L. Turka, C. LeGuern.

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    Background: Regulatory T cell (Tregs) therapy remains a promising strategy for minimizing immunosuppression and extending allograft survival. Although Treg suppression requires initial activation through cell…
  • 2017 American Transplant Congress

    Effects of New KPD Histocompatibility Policy on Refusal Rate and Transplants.

    R. Leishman,1 M. Aeder,2 M. Leffell,3 C. Murphey,4 N. Reinsmoen,5 S. Saidman,6 T. Sandholm,7 A. Toll,1 A. Harper,1 N. Turgeon.8

    1UNOS, Richmond, VA; 2Univ Hosp Med Ctr, Cleveland, OH; 3Johns Hopkins Univ, Baltimore, MD; 4SW Immunodiagnostics, San Antonio, TX; 5Cedars-Sinai Health, Los Angeles, CA; 6Mass Gen Hosp, Boston, MA; 7Carnegie Mellon Univ, Pittsburgh, PA; 8Emory Univ, Atlanta, GA

    Background: Transplant centers commonly refuse kidney paired donation (KPD) match offers due to unacceptable crossmatch (XM). To reduce XM refusals a new OPTN KPD histocompatibility…
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