2016 American Transplant Congress
Optimizing CPRAs for Sensitized Kidney Waitlist Candidates: The Devil Is in the KAS Details.
The new kidney allocation system (KAS) has increased transplant rates for highly sensitized candidates. We hypothesized that increasing unacceptable antigens to transition candidates from 80-98%…2016 American Transplant Congress
Optimized Flow Cytometry Crossmatch with Increased Sensitivity and Specificity.
The flow cytometry crossmatch (FCXM) is the standard method to prevent hyperacute rejection after transplantation. Surprisingly, few technical improvements have been introduced to the FCXM…2016 American Transplant Congress
Anti-HLA Antibodies in Allogeneic and Autologous Hematopoietic Stem Cell Transplantation.
Introduction: Anti-HLA antibodies have been associated with graft rejection in solid organ and hematopoietic stem cell transplantation (HSCT). The aim of this study was describe…2016 American Transplant Congress
Prognosis Value of the Presence and Persistence of C1q Binding Anti-HLA Antibodies in Acute Antibody-Mediated Rejection in Kidney Transplantation.
Purpose : Longitudinal study of C1q complement fraction binding capacity of donor specific anti-HLA antibodies (DSAs) as a pronostic marker in acute antibody-mediated rejection.Methods :…2016 American Transplant Congress
Complex Constellation of HLA Antibodies Contributes to Decreasing Trend of Transplant Rate in Candidates with 100% CPRA.
The key component of new KAS is offering an increased priority for sensitized candidates. While transplants (tx) have increased six-fold for recipients with a CPRA…2016 American Transplant Congress
Immunogenic HLA-DR Eplet Mismatches as Predictors of Transplant Glomerulopathy.
BackgroundThe number of HLA-DR eplet mismatches (eplet load) is a risk factor for the development of anti-HLA antibodies and transplant glomerulopathy (TG). In the case…2016 American Transplant Congress
Increased Access to Transplantation of Highly Sensitized Patients Facilitated by the New Kidney Allocation System.
Abdominal Transplant, Montefiore Medical Center, Bronx, NY.
The purpose of our study was to evaluate the impact of the new kidney allocation system (KAS 2014) on the access to transplantation of HLA…2016 American Transplant Congress
Blocking Fc Receptor in Flow Cytometric Crossmatch: Refining an Old Assay to Improve Patient Management.
Pathology, University of Chicago, Chicago, IL.
Introduction: The crossmatch assay is used to determine sensitization of solid organ transplant recipients to donor-expressed HLA molecules, a potential contraindication to transplant. Multicolor flow…2015 American Transplant Congress
HLA-Cw Mismatches Are Not Associated With Worse Graft Outcomes After Kidney Transplantation Even in High Levels of Antigen Expression
1Cleveland Clinic, Cleveland; 2University of Alexandria, Alexandria, Egypt.
The HLA-Cw antigens are distinct in having relatively lower expression on the cell surface compared to the other HLA class I loci. Higher HLA Cw…2015 American Transplant Congress
Clinical Relevance of C3d-Binding Donor-Specific Antibodies in Late Kidney Allograft Failure
Background: The objective of this study was to investigate the prognostic value of C3d-binding donor-specific antibodies (DSA) in determining late kidney allograft failure.Methods: 1048 patients…
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