ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histocompatibility"

  • 2021 American Transplant Congress

    The Co-Occurrence of Newly Developed HLA Donor Specific Antibody and Positive C3d/C4d Profiles Along with Immune Therapy Non-Compliance in Pediatric Heart Transplant Recipients is a High Risk Indicator for Patient Mortality

    A. Zhang, C. Nasman, J. Allen, Y. Sun, D. Thomas, R. Rodriguez, C. Tan, G. Boyle

    Cleveland Clinic Foundation Transplant Center, Cleveland, OH

    *Purpose: Increasing evidence has implicated the deleterious effect of HLA donor specific antibody (DSA) in pediatric heart transplantation (PHTx). However, there are still insufficient research…
  • 2021 American Transplant Congress

    Influence of HLA Compatibility on Bk Virus Associated Nephropathy Among Japanese Living Donor Kidney Transplant Recipients

    N. Fujiyama1, M. Saito2, R. Yamamoto2, R. Sagehashi2, T. Saito2, S. Kashima2, K. Numakura2, S. Narita2, T. Habuchi2, S. Satoh1

    1Center for Kidney Disease and Transplantaion, Akita University Hospital, Akita, Japan, 2Department of Urology, Akita University Graduate School of Medicine, Akita, Japan

    *Purpose: BK polyomavirus-associated nephropathy (BKVN) after kidney transplantation is associated with a high morbidity and higher risk of graft loss. In this study, the relationship…
  • 2021 American Transplant Congress

    HLA Haplotype Frequency and Racial Disparities in Access to Transplant Among Highly Sensitized Kidney Transplant Candidates

    L. Gragert1, M. Kadatz2, D. Chang2, H. Gebel3, D. Stewart4, E. Kransdorf5, S. Brar2, S. Vaishnav2, J. Gill2, J. Lan2

    1Tulane University, New Orleans, LA, 2University of British Columbia, Vancouver, BC, Canada, 3Emory University, Atlanta, GA, 4UNOS, Richmond, VA, 5Cedars-Sinai, Beverly Hills, CA, Canada

    *Purpose: Despite implementation of the Kidney Allocation System (KAS) which prioritizes sensitized patients, sensitized Black individuals are less likely to receive a transplant than non-Black…
  • 2021 American Transplant Congress

    Is Equitable Access to Transplantation Possible in the Era of HLA Epitope Compatibility?

    S. Parto1, J. Lamsatfi2, B. Liu2, A. Bourdiec2, B. Foster2, K. Oualkacha2, F. Claas3, P. Keown4, R. Sapir-Pichhadze5

    1Medicine, McGill University, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada, 3Leiden University Medical Centre, Albinusdreef, Netherlands, 4University of British Columbia, Vancouver, BC, Canada, 5Medicine, McGill University Health Centre, Montreal, QC, Canada

    *Purpose: We applied the calculated Panel of Incompatible Epitopes (cPIE), an algorithm informing on the likelihood of identifying blood group and eplet-compatible donors, to study…
  • 2021 American Transplant Congress

    Dynamics of IgG Subclass as a Mechanism of Desensitization Using Rituximab for Presensitized Patients Undergoing Living Related Liver Transplantation

    H. Egawa1, K. Ide2, T. Ishizuka3, H. Ohdan4, Y. Kotera1, T. Kato1, A. Ohmori1, Y. Hirata1, G. Shibuya1, S. Yamashita1, S. Ariizumi1

    1Tokyo Women's Medical University, Tokyo, Japan, 2Surgery, Hiroshima University, Hiroshima, Japan, 3Clinical Laboratory, Tokyo Women's Medical University, Tokyo, Japan, 4Hiroshima University, Hiroshima, Japan

    *Purpose: Although impact of preformed HLA-related donor specific antibody (DSA) and necessity of desensitization in liver transplantation (LT) has been recognized, mechanisms of desensitization in…
  • 2021 American Transplant Congress

    Post-Transplant Outcomes Comparing A2 Incompatible to Compatible Deceased Donor Liver Transplant Recipients

    T. Chiang, M. A. Eagleson, S. Bae, J. Garonzik-Wang, D. Segev, A. B. Massie

    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Transplantation of A2 livers into type O and B recipients (A2i DDLT) is a growing modality to increase access to DDLT for O and…
  • 2021 American Transplant Congress

    The Calculated Panel of Incompatible Epitopes (cPIE) in the Service of Equitable Access to Transplantation

    J. Lamsatfi1, B. Bingfan Liu1, S. Parto2, A. Lewin3, K. Oualkacha1, F. Claas4, P. Keown5, R. Sapir-Pichhadze6

    1McGill University, Montreal, QC, Canada, 2McGill University Health Centre, Montreal, QC, Canada, 3Hema-Quebec, Montreal, QC, Canada, 4Leiden University Medical Centre, Albinusdreef, Netherlands, 5University of British Columbia, Vancouver, BC, Canada, 6Medicine, McGill University Health Centre, Montreal, QC, Canada

    *Purpose: To inform on feasibility of eplet matching, we developed the calculated Panel of Incompatible Epitopes (cPIE), an algorithm informing on the likelihood of identifying…
  • 2020 American Transplant Congress

    A Multicenter Analysis of the Proportion and Pattern of Unexplained HLA Antibodies in Kidney Recipients without a History of Sensitization

    J. Lan1, J. S. Gill1, H. M. Gebel2, R. A. Bray2, R. Liwski3, A. Vinson4, A. Greenshields3, S. Dobrer5, O. Gunther5, K. Sherwood5, F. H. Claas6, S. Heidt6, G. Karahan6, J. Gill7, M. Gill1, U. Varyani1, P. Jindal1, P. Keown5

    1Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada, 2Pathology, Emory University, Atlanta, GA, 3Pathology, Dalhousie University, Halifax, NS, Canada, 4Nephrology, Dalhousie University, Halifax, NS, Canada, 5Pathology, University of British Columbia, Vancouver, BC, Canada, 6Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands, 7Nephrology, Emory University, Atlanta, GA

    *Purpose: Previous studies report a high prevalence of unexplained antibody reactivities on the single antigen bead (SAB) test. In a contemporary multicenter cohort of non-sensitized…
  • 2020 American Transplant Congress

    HLA Specific Antibody Levels after EDTA Treatment in CDC Crossmatch Positive and Negative Sera with Known Donor-Specific Antibodies

    J. Lauronen1, T. Jaatinen1, J. Holgersson2, C. Naper3, J. Peräsaari1

    1Histocompatibility Laboratory, Finnish Red Cross Blood Service, Helsinki, Finland, 2Department of Laboratory Medicine, Sahlgrenska Academy at University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden, 3Histocompatibility Laboratory, Oslo University Hospital, Oslo, Norway

    *Purpose: Ethylenediaminetetraacetic acid (EDTA) treatment of serum samples overcomes the prozone effect that may interfere with solid phase HLA specific antibody analyses. In patients with…
  • 2020 American Transplant Congress

    The Clinical Relevance of cPRA in 0-ABDRDQ Mismatched Kidney Transplants

    J. H. Lan1, D. Chang1, M. Kadatz1, J. Gill1, H. M. Gebel2, J. S. Gill1

    1Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada, 2Pathology, Emory University, Atlanta, GA

    *Purpose: The clinical relevance of immune sensitization as measured by cPRA in kidney transplantation remains uncertain.*Methods: We identified 4,057 adult, first, kidney only transplant recipients…
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