Session Name: Kidney: Polyoma
Session Date & Time: None. Available on demand.
*Purpose: BK polyomavirus-associated nephropathy (BKVN) after kidney transplantation is associated with a high morbidity and higher risk of graft loss. In this study, the relationship between BKVN post-kidney transplantation and HLA, and between killer immunoglobulin-like receptor (KIR) compatibility of recipients and donors was evaluated.
*Methods: We included 228 cases among patients who received a living kidney transplants at Akita University Hospital from December 2004 to November 2016. BKVN replication was evaluated by detection of decoy cells in urine cytology smears and/or immunohistochemical staining by simian virus 40 positive cells in graft biopsy. Using HLA and KIR haplotypes were determined by WAKFlow and LAB type reagents, HLA loci type and HLA match/HLA-KIR match between donor and recipient were evaluated.
*Results: Eleven cases were diagnosed with BKVN infection after renal transplant (4.8% of the total). In the analysis using HLA loci type, BKVN was significantly high frequency in A24 and DR14 carriers compared with each non-carrier (8.4% vs 0.9%; p=0.011 and 12.8% vs 2.8%; p=0.011, respectively). In the analysis using HLA match, the incidence in the 2- or 1-match case group of HLA-DR14 was significantly higher than in the 0-match case group (19.0% vs. 3.4%, p=0.012) while there were no association of BKVN with other HLA match. In Kaplan-Meier analysis, HLA-A24 carrier, HLA-DR14 carrier and HLA-DR14 match were significantly high morbidity compared with non-carrier/match (p=0.009, p=0.005 and p=0.002, respectively). On the other hand, as a result of comparison among KIR haplotypes and of comparison with or without KIR-ligand match between recipient KIR and donor HLA, there were no significant different of BKVN frequency.
*Conclusions: HLA and match/mismatch in kidney transplantation are important not only for suppressing alloresponse but also for predicting BKVN.
To cite this abstract in AMA style:Fujiyama N, Saito M, Yamamoto R, Sagehashi R, Saito T, Kashima S, Numakura K, Narita S, Habuchi T, Satoh S. Influence of HLA Compatibility on Bk Virus Associated Nephropathy Among Japanese Living Donor Kidney Transplant Recipients [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/influence-of-hla-compatibility-on-bk-virus-associated-nephropathy-among-japanese-living-donor-kidney-transplant-recipients/. Accessed June 11, 2021.
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