2019 American Transplant Congress
Absence of Antibodies in Human Neonates and Infants to Gtko/cmahko/β4galnt2ko (Triple Gene Knockout) Pig Cells: Relevance to Cardiac Xenotransplantation for Complex Congenital Heart Disease
1Surgery, University of Alabama at Birmingham, Birmingham, AL, 2Revivicor Inc., Blacksburg, VA
*Purpose: Heart transplantation (Tx) in neonates is associated with the best results of any organ Tx, but the lack of deceased human donor hearts in…2019 American Transplant Congress
Development of Non-Human Leukocyte Antigen Antibodies in Cardiac Antibody-Mediated Rejection
*Purpose: Antibody-mediated rejection (AMR), mainly driven by the development of donor-specific antibodies (DSA) directed against mismatched donor class I and class II HLA, is a…2019 American Transplant Congress
Hepatocellular Carcinoma in Fontan Liver Disease
1Internal Medicine, Emory, Atlanta, GA, 2Emory, Atlanta, GA
*Purpose: To add to the clinical characteristics and outcomes of hepatocellular carcinoma (HCC) in post Fontan operation patients and present, to the best of our…2019 American Transplant Congress
Risk Stratification of Patients Undergoing Simultaneous Liver Transplantation and Cardiac Surgery
Cleveland Clinic, Cleveland, OH
*Purpose: Evaluate risk factors and outcomes of combined liver transplantation (OLT) and cardiac surgery, including coronary artery grafting and valve replacement.*Methods: Between 1/2005 and 8/2018,…2019 American Transplant Congress
Immunosuppressant Adherence in Adult Heart Transplant Recipients: An Analysis of Pharmacy Claims and Organ Procurement and Transplantation Network Data
*Purpose: The current study was conducted to determine characteristics that are associated with immunosuppressant (IS) medication adherence among adult recipients of deceased donor heart transplants…2019 American Transplant Congress
Statin Underutilization in Patients Listed for Liver Transplant
*Purpose: Current guidelines recommend statin use in high risk patients based on the ASCVD (atherosclerotic cardiovascular disease) score, diabetes, or LDL levels. Despite several trials…2019 American Transplant Congress
Donor Brain Death Affects Tolerance Induction in Non-Human Primates
*Purpose: Induction of durable allograft acceptance in combined heart/kidney transplantation in non-human primates is possible by applying a mixed chimerism-based conditioning protocol. However, the impact…2018 American Transplant Congress
T Cell-Mediated Rejection Poses Greater Risk to Graft Survival Than Antibody-Mediated Rejection in Heart Transplants
University of Alberta, Edmonton, Canada.
Purpose: In kidney transplants, failure post-biopsy is associated with acute injury transcript expression reflecting the histologically silent tissue response-to-wounding (JCI 120:1862) and antibody-mediated rejection (ABMR),…2018 American Transplant Congress
Experience in the Development of a Life-Supporting Large Animal Orthotopic Cardiac Xenotransplant Model
Advances in clinical immunosuppression and characterization of optimal donor genetics continue to move the field of xenotransplantation toward a clinical reality with extremely long-term survival…2018 American Transplant Congress
Geographic Variation in the Survival Benefit of Heart Transplantation
1University of Chicago, Chicago, IL; 2Northwestern University, Chicago, IL.
Purpose: Heart transplant candidate selection and treatment practices vary substantially across the US. We aimed to determine if transplant center practices modify the survival benefit…
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