2018 American Transplant Congress
Geographic Variation in the Treatment of Adult Heart Transplant Candidates in the US
1University of Chicago, Chicago, IL; 2Northwestern University, Chicago, IL.
The current priority ranking system for US heart transplant candidates is based on treatment intensity which may encourage the overtreatment of relatively stable candidates. We…2018 American Transplant Congress
Myeloid-Derived Suppressor Cells Suppress with Enhanced Donor Specificity in Donor ECDI-SP Treated Recipients
Northwestern University Feinberg School of Medicine, Chicago.
Introduction: Published data in cancer models have shown that myeloid-derived suppressor cells (MDSCs) can induce antigen-specific CD8 T cell tolerance and promote tumor escape (Nagaraj…2018 American Transplant Congress
Heart Transplantation in Patients with Complex Congenital Heart Disease
Cedars Sinai Medical Center, Los Angeles.
Purpose: As medical and surgical management of complex congenital heart disease (CCHD) improves, patients may survive into adulthood to suffer from end-stage heart failure and…2018 American Transplant Congress
Human Thrombomodulin Expression on Genetically Modified Donor Pigs is Required to Maintain the Anti-Coagulation Profile
Introduction: Coagulation dysregulation is major limitation for xenotransplantation but it is resolved to some extent by making genetically engineered (GE) pigs, which express complement inhibitors…2018 American Transplant Congress
Differences in Pediatric and Adult Lost to Follow-Up Events for Heart, Kidney, and Liver Recipients
Background: Long-term follow-up data are necessary for accurate survival estimation. While the majority of heart (HR), kidney (KI), and liver (LI) transplant recipients (TxR) are…2018 American Transplant Congress
Screening of RhoA/ROCK Inhibitors for the Ability to Prevent Chronic Rejection of Mouse Cardiac Allografts
Objectives. Chronic rejection of transplanted organs is a major obstacle in human organ transplantation. Although the mechanisms of chronic rejection are poorly understood it is…2018 American Transplant Congress
Heart and Lung Offer Acceptance Practices Are Associated with Organ Yield and Local Placement
Below average offer acceptance practices could delay placement of donor hearts and lungs and may ultimately lead to organ discard. Recovered thoracic organs are rarely…2018 American Transplant Congress
T Cell-Mediated Rejection Poses Greater Risk to Graft Survival Than Antibody-Mediated Rejection in Heart Transplants
University of Alberta, Edmonton, Canada.
Purpose: In kidney transplants, failure post-biopsy is associated with acute injury transcript expression reflecting the histologically silent tissue response-to-wounding (JCI 120:1862) and antibody-mediated rejection (ABMR),…2018 American Transplant Congress
Experience in the Development of a Life-Supporting Large Animal Orthotopic Cardiac Xenotransplant Model
Advances in clinical immunosuppression and characterization of optimal donor genetics continue to move the field of xenotransplantation toward a clinical reality with extremely long-term survival…2018 American Transplant Congress
Geographic Variation in the Survival Benefit of Heart Transplantation
1University of Chicago, Chicago, IL; 2Northwestern University, Chicago, IL.
Purpose: Heart transplant candidate selection and treatment practices vary substantially across the US. We aimed to determine if transplant center practices modify the survival benefit…
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