Articles tagged "Heart"

2021 American Transplant Congress
Cd4 T Cells Can Trigger Nk-dependent Chronic Rejection Independent of Antibodies
R. G. Gill¹, B. Mehrad², C. M. Lin²
¹Surgery, University of Colorado Denver, Aurora, CO, ²Medicine, University of Florida, Gainesville, FL
*Purpose: In transplantation, recipient CD4+ T cells have two potential means of MHC class II-restricted donor antigen detection: (1) the direct recognition of allogeneic MHC…
2021 American Transplant Congress
DSA is Associated with Molecular Changes in Many Hearts with Minor Abnormalities but Not Diagnosed as Antibody-Mediated Rejection
P. Halloran¹, K. S. Madill-Thomsen¹, &. the INTERHEART Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: We previously developed a microarray-based diagnostic system (MMDx) for heart transplant endomyocardial biopsies, measuring gene expression and interpreting antibody-mediated and T cell-mediated rejection (ABMR,…
2021 American Transplant Congress
Changes to Adult Heart Allocation Improve Candidate Stratification
K. Bradbrook¹, K. Lindblad¹, R. R. Goff¹, R. Daly², S. Hall³
¹Research, United Network for Organ Sharing, Richmond, VA, ²Mayo Clinic, Rochester, MN, ³Baylor University Medical Center, Dallas, TX
*Purpose: Historically, heart allocation has been driven by waitlist (WL) mortality rather than post-transplant survival. On 10/18/2018 the Organ Procurement and Transplantation Network (OPTN) implemented…
2021 American Transplant Congress
Ex Situ Heart Perfusion and Standard of Care Cold Storage Differentially Affect the Ischemic Secretome of Donor Hearts in Perfusates but Not the Reperfusion Response in Recipient Plasma
E. Chichelnitskiy¹, B. Wiegmann², N. Ledwoch¹, F. Ius², F. Wandrer¹, J. Kühne¹, K. Beushausen¹, J. Keil¹, S. V. Rojas², W. Sommer², C. Kühn², I. Tudorache², M. Avsar², A. Haverich², G. Warnecke², C. S. Falk¹
¹MHH, Institute of Transplant Immunology, Hannover, Germany, ²MHH, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover, Germany
*Purpose: Various allograft preservation procedures influence the donor organ status that may be reflected by the cytokine/chemokine microenvironment in heart transplant (HTx) recipients. In addition,…
2021 American Transplant Congress
A Patient-Centered Perspective on Progress in Transplantation
B. Hickner¹, N. Galvan², R. Cotton², C. O'Mahony², J. Goss², A. Rana²
¹Department of Student Affairs, Baylor College of Medicine, Houston, TX, ²Department of Surgery, Baylor College of Medicine, Houston, TX
*Purpose: This study aimed to provide a patient-centered perspective on change in transplantation outcomes through analysis of intent-to-treat survival, which accounted for donor shortages by…
2021 American Transplant Congress
Intensivist-Performed Transesophageal Echocardiography as a Screen for Organ Donation: A Four-Year, Single-Center Experience
K. M. Madden¹, T. C. Wray², K. Rainbird¹, I. Tawil², T. Dettmer², K. Azevedo², R. Venkataramani³, J. Marinaro²
¹New Mexico Donor Services, Albuquerque, NM, ²Emergency Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, ³Anesthesiology, University of New Mexico Health Sciences Center, Albuquerque, NM
*Purpose: Echocardiography is required for deceased heart donation, and transthoracic echocardiography is the traditional practice. At our institution, intensivists perform transesophageal echocardiography (TEE) and since…
2021 American Transplant Congress
Adult Combined Liver-Heart Transplantation: The United States Experience
I. A. Ziogas¹, S. P. Alexopoulos¹, W. K. Wu¹, L. K. Matsuoka¹, M. A. Rauf¹, M. Izzy², R. Perri², K. H. Schlendorf³, J. N. Menachem³, A. S. Shah⁴
¹Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN, ²Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, ³Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, ⁴Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN
*Purpose: Combined heart-liver transplantation (CHLT) is now being practiced with increasing regularity and improved outcomes in the United States. We performed the most comprehensive review…
2021 American Transplant Congress
Breakthrough Cytomegalovirus DNAemia in High vs Intermediate Risk Heart Transplant Recipients
G. Huang¹, O. E. Beaird¹, M. Davis², M. Carlson¹, S. Chang¹, P. Gaynor¹, A. Fan², M. Deng³, A. Multani¹, A. Nsair³, J. Schaenman¹
¹Infectious Diseases, UCLA, Los Angeles, CA, ²Pharmacy, UCLA, Los Angeles, CA, ³Cardiology, UCLA, Los Angeles, CA
*Purpose: Cytomegalovirus (CMV) is one of the most common infections after transplantation and continues to cause significant morbidity and mortality despite prophylaxis and screening strategies.…
2021 American Transplant Congress
The Gut Microbiome in Heart Transplantation: A Prospective Pilot Study
M. Dela Cruz¹, E. Littmann², R. Nayak², C. Lehmann², R. Keskey³, T. Baker³, H. Lin², A. Bennett¹, G. Kim¹, S. Pinney¹, E. Pamer², A. B. Nguyen¹
¹Cardiology, University of Chicago, Chicago, IL, ²Medicine, University of Chicago, Chicago, IL, ³Surgery, University of Chicago, Chicago, IL
*Purpose: The contribution of the intestinal microbiome to alloimmunity in heart transplantation (HT) is unknown. We examined the fecal microbiota of HT recipients at the…
2021 American Transplant Congress
Impact of New Onset Diabetes After Transplantation on Heart Transplant Recipients
W. Kang¹, W. Keattiyoat², M. Kim¹, C. Bhardwaj²
¹Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, ²Department of Cardiology, University of Illinois College of Medicine at Peoria, Peoria, IL
*Purpose: The purpose of this study is to investigate New Onset Diabetes After Transplantation (NODAT) incidence and its impact on post-transplant prognosis in adult heart…

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