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American Transplant Congress abstracts

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Articles tagged "Heart"

  • 2022 American Transplant Congress

    An Updated Estimate of Post-Transplant Survival After Implementation of the New Donor Heart Allocation Policy

    K. A. Lazenby1, N. Narang2, K. M. Pelzer3, G. Ran1, W. F. Parker3

    1Pritzker School of Medicine, University of Chicago, Chicago, IL, 2Advocate Heart Institute, Advocate Christ Medical Center, Chicago, IL, 3Department of Medicine, University of Chicago, Chicago, IL

    *Purpose: Published estimates showing lower post-transplant survival after implementation of the new heart allocation policy may be biased downward due to incomplete follow-up on surviving…
  • 2022 American Transplant Congress

    TNX-1500, an Fc-Modified Anti-cd154 Antibody, Prolongs Nonhuman Primate Cardiac Allograft Survival

    S. Miura1, Z. Abady1, F. Pollok1, M. Ma1, K. Kinoshita1, S. Fogarty2, P. Maguire2, B. Daugherty2, S. Lederman2, R. Pierson III1

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, 2Tonix Pharmaceuticals, Chatham, NJ

    *Purpose: Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to replace current clinical immunosuppression. TNX-1500 (TNX) is a novel humanized anti-CD154…
  • 2022 American Transplant Congress

    Ventricular Modeling Following Bariatric Surgery Decreases Need for Heart Transplantation

    R. Choudhury1, A. Rouhi2, G. Hoeltzel3, Y. Bababekov1, A. Suarez-Pierre4, A. Yule1, N. Vigneshwar4, N. Williams5, K. Dumon2, T. Nydam1

    1Transplantation Surgery, University of Colorado Hospital, Aurora, CO, 2General Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, 3General Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, 4Cardiothoracic Surgery, University of Colorado Hospital, Aurora, CO, 5General Surgery, Hospital of the University of Pennsylvania, Aurora, CO

    *Purpose: For obese patients with congestive heart failure (CHF), aggressive weight loss has been associated with ventricular remodeling. Many have suggested offering bariatric surgery for…
  • 2022 American Transplant Congress

    Successful Use of Anti-IL-6R Therapy to Achieve Cardiac Allograft Tolerance in Non-Human Primates

    C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, A. Dehnadi, T. Costa, M. Momodu, J. A. Morrissette, D. Muldoon, I. M. Hanekamp, J. S. Allan, G. Benichou, J. C. Madsen

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: In contrast to kidney allografts, attempts to achieve tolerance of isolated cardiac allografts in non-human primates (NHPs) using a mixed chimerism strategy have been…
  • 2022 American Transplant Congress

    Estimating the Effect of Increased Donor Heart Ischemic Time on Post-Transplant Survival Using Instrumental Variables

    G. Ran1, K. Lazenby1, N. Narang2, W. F. Parker3

    1Pritzker School of Medicine, University of Chicago, Chicago, IL, 2Department of Medicine, University of Illinois-Chicago, Chicago, IL, 3Department of Medicine, University of Chicago, Chicago, IL

    *Purpose: Isolate the impact of organ ischemic time on post-transplant survival using the recent change in heart allocation policy as a natural experiment.*Methods: We examined…
  • 2022 American Transplant Congress

    Outcome of Solid Organ Transplantation in Candidates with Intellectual Disability: A Systematic Review

    L. Orlandini

    Erasmus MC, Rotterdam, Netherlands

    *Purpose: The allocation of organs comes with an ethical discussion in patients with intellectual disability. Historically, intellectual disability was considered a relative contra-indication for organ…
  • 2022 American Transplant Congress

    The Role of Geography in Adult Heart Allocation Over the Last 5 Years

    K. Bradbrook1, R. Goff1, R. Daly2, S. Hall3

    1Research, United Network for Organ Sharing, Richmond, VA, 2Mayo Clinic, Rochester, MN, 3Baylor University Medical Center, Dallas, TX

    *Purpose: In the last 5 years two policies have impacted the role of geography in adult heart allocation including the 2018 adult heart policy which…
  • 2022 American Transplant Congress

    Cd47 Expression on Transplanted Human Neonatal Mesenchymal Stem Cells Inhibits Phagocytosis in Rat Myocardial Infarction Model

    M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal

    Lurie Childrens Hospital, Chicago, IL

    *Purpose: Immune rejection of transplanted stem/progenitor cells is a major stumbling block in designing effective therapy for myocardial infarction (MI). Human neonatal mesenchymal stem cells…
  • 2022 American Transplant Congress

    Correlating Histology, Immunohistochemical, & Serologic Data in Heart Transplant Recipients: Implications for Molecular Diagnostic Assays

    P. Randhawa, Y. Huang

    University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: The ISHLT classification of rejection in heart allograft biopsies is independent of DSA status. There is only limited data on the prevalence of DSA…
  • 2022 American Transplant Congress

    Significant Reduction of Troponin I Elaboration After Ischemia Minimization in the First Hour of Ex Vivo Xeno Heart Perfusion

    F. Pollok1, M. R. Connolly1, A. Calhoun1, Z. Habibabady1, S. Miura1, M. Ma1, S. Pratts1, L. Burdorf1, Y. Kan2, J. V. Layer2, J. V. Layer2, E. Tan2, R. Anand2, M. Li2, K. C. Hall2, M. E. Youd2, K. Stiede2, W. Qin2, M. Curtis2, A. Azimzadeh1, R. N. Pierson1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Cambridge, MA, 2eGenesis Inc., Cambridge, MA

    *Purpose: Previous studies showed that ischemia minimization (IM), accomplished by perfusing the heart xenograft during storage, prevents ‘initial cardiac xenograft dysfunction’ (ICXD) and enables prolonged…
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