Articles tagged "Heart"

2020 American Transplant Congress
The Impact of the New Heart Allocation Policy on the Treatment of United States Adult Heart Transplant Candidates
K. Chung¹, A. S. Anderson², M. Siegler¹, M. M. Churpek³, W. Parker¹
¹University of Chicago Pritzker School of Medicine, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: In October 2018, the US heart allocation system expanded the number of priority “Status” tiers from 3 to 6 and added cardiogenic shock requirements.…
2020 American Transplant Congress
Affect in Patients Awaiting Heart Transplant
A. Ahmed¹, D. S. Yip², B. W. Hardaway³, B. A. Boilson⁴, T. D. Schneekloth⁵, R. Benzo¹, R. Daly⁶, M. A. Hathcock⁷, B. K. Johnson⁷, K. Thompson⁸, C. C. Kennedy⁹
¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, ²Department of Transplantation, Mayo Clinic, Jacksonville, FL, ³Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, AZ, ⁴Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, ⁵Department of Psychiatry, Mayo Clinic, Rochester, MN, ⁶Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN, ⁷Department of Health Services Research -Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, ⁸Pulm onary Clinical Research Unit, Mayo Clinic, Rochester, MN, ⁹William J. von Liebig Center for Transplantation and Regenerative Medicine, Mayo Clinic, Rochester, MN
*Purpose: Affect refers to an individual’s emotional response .It may be categorized as positive or negative. Affect in heart transplant candidates is under-explored. We aimed…
2020 American Transplant Congress
A Single Center Experience of Atypical Hemolytic Uremic Syndrome Post Solid Organ Transplantation – “Benign Genetic Variants: Perhaps No More”
M. Khan, M. Anand, T. Kaur, S. Bumb, S. Shah, A. Govil, B. G. Abu Jawdeh
University of Cincinnati, Cincinnati, OH
*Purpose: Atypical hemolytic uremic syndrome (aHUS) is a genetic-based thrombotic microangiopathy (TMA) that is mediated by the activation of the alternative complement pathway. Heterozygous deletion…
2020 American Transplant Congress
A Comparison of Temporal Gene Expression Patterns in Kidney, Heart, Liver, and Lung Transplant Biopsies
P. Halloran¹, J. Reeve¹, .. the INTERLUNG Study Group², .. the INTERHEART Study Group², .. the INTERLIVER Study Group², &. the INTERCOMEX Study Group²
¹University of Alberta, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: Gene expression patterns change with time post-transplant. The MMDx system makes it possible to do cross-organ comparisons using the same microarray platform and gene…
2020 American Transplant Congress
UNOS Registry Myocarditis Heart Transplantation Outcome
J. P. Li¹, P. Kingsford¹, S. Nuno¹, D. Miklin¹, G. Liu², J. Rahman², K. Pandya², C. Lum³, P. Banankhah², P. Genyk¹, D. Vucicevic⁴, A. Wolfson⁵, R. Chand⁶, K. Yang¹, S. Shah¹, A. Kiankhooy⁷, J. Nattiv², S. Hashmi¹, J. Pizula¹, A. Lee¹, M. Fong², L. Grazette², E. C. DePasquale², A. S. Vaidya²
¹Internal Medicine, Keck Medicine of USC, Los Angeles, CA, ²Cardiology, Keck Medicine of USC, Los Angeles, CA, ³Internal Medicine, The Queen's Medical Center, Honolulu, HI, ⁴Cardiology, Newark Beth-Israel Medical Center, Newark, NJ, ⁵Cardiology, University of Arizona Sarver Heart Center, Tuscon, AZ, ⁶Cardiology, Harbor-UCLA Medical Center, Los Angeles, CA, ⁷Cardiothoracic Surgery, Keck Medicine of USC, Los Angeles, CA
*Purpose: Hospitalized myocarditis patients have a variable course that can require heart transplantation at a rate of about 3-4%. We sought to evaluate the post-transplant…
2020 American Transplant Congress
Novel Mechanism of Immune Evasion by Human Neonatal Cardiac Progenitor Cells Recovers Ailing Myocardium in Rat Myocardial Infarct Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Wang, M. Yasir Arfat, L. Davidson, X. Fu, A. Shah, M. Abdullah, D. Li, S. Kaushal
Surgery, University of Maryland, Baltimore, MD
*Purpose: Immune rejection of transplanted stem/progenitor cells is a major stumbling block in designing effective therapy for myocardial infarction (MI). Human neonatal cardiac progenitor cells…
2020 American Transplant Congress
Suppressing Laminin Alpha5 Creates Tolerogenic Niches for Allograft Survival
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) regulates CD4 T cell migration and function. We hypothesized that stromal Lama5 regulates the structure of the lymph node (LN) microenvironment…
2020 American Transplant Congress
Risk Epitope Mismatch Does Not Predict Short Term Heart Transplant Outcomes
Y. Moayedi¹, J. McCaughan², E. Henricksen³, B. Mueller⁴, S. Fan⁴, H. J. Ross¹, K. Khush⁵, B. M. Zhang⁶, J. Teuteberg⁵
¹Cardiology, Ted Rogers Centre for Heart Research, University Health Network, University of Toronto, Toronto, ON, Canada, ²HLA Lab, Belfast Trust, Belfast, Ireland, ³Pharmacy, Stanford Healthcare, Stanford, CA, ⁴Computational Program TRCHR, Ted Rogers Centre for Heart Research, University Health Network, University of Toronto, Toronto, ON, Canada, ⁵Cardiology, Stanford University, Stanford, CA, ⁶HLA Lab, Stanford University, Stanford, CA
*Purpose: Heart transplantation (HT) remains the gold standard treatment for end-stage heart failure. Despite significant improvements in short-term outcomes, the median survival after heart transplantation…
2020 American Transplant Congress
Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates
P. M. Patel¹, B. A. Gonzalez Nolasco¹, J. A. Morrissette¹, A. Prunevieille¹, K. J. Ahrens¹, J. M. O¹, D. C. Becerra¹, G. Benichou¹, J. C. Madsen²
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Cardiac allograft tolerance in non-human primates (NHPs) has been achieved by our group via hematopoietic mixed chimerism consisting of an allogeneic bone marrow (BM)…
2020 American Transplant Congress
Variations in Recipient and Donor Clinical Characteristics between Heart Transplant Centers
W. T. McKinney¹, M. J. Bruin², S. Chu², D. Schladt³, J. Synder³, C. M. Martin⁴, T. Alexy⁴, B. L. Kasiske⁵, A. K. Israni¹
¹Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, ²College of Design, University of Minnesota, Minneapolis, MN, ³Hennepin Healthcare Research Institute, Minneapolis, MN, ⁴Cardiology Division, University of Minnesota Department of Medicine, Minneapolis, MN, ⁵Department of Medicine, Hennepin Healthcare, Minneapolis, MN
*Purpose: When a patient has discretion over which heart transplant program will evaluate them for the waitlist, prior knowledge of program acceptance practices can enable…