Articles tagged "Graft survival"

2016 American Transplant Congress
Clinical Outcomes of Kidney Allograft Recipients with Apolipoprotein L1 (APOL1) Risk Alleles from Living Kidney Donors.
C. Dorr,^1,2,3 A. Hart,^1,2,3 D. Schladt,¹ A. Muthusamy,¹ R. Mannon,⁴ W. Oetting,² A. Matas,² P. Jacobson,² A. Israni.^1,2,3
¹Minneapolis Medical Research Foundation, Minneapolis; ²University of Minnesota, Minneapolis; ³Hennepin County Medical Center, Minneapolis; ⁴University of Alabama, Birmingham.
Background:Apolipoprotein L1 (APOL1) alleles G1 and G2 in deceased donors are associated with poor kidney allograft survival. However, the effect of these alleles in living…
2016 American Transplant Congress
Chemokine Receptor CXCR4 Antagonist, a Novel Pathway to Prevent Chronic Allograft Nephropathy.
Y. Xu, Q. Zhang, X. Hu.
Department of Urology, Beijing Chaoyang Hospital, Beijing, China.
BackgroundChronic allograft nephropathy (CAN) remains a major problem for long term graft survival and different pathways participate in its development. CXC chemokine receptor 4 (CXCR4)…
2016 American Transplant Congress
Targeting the Constitutively Active PI3K/Akt/mTOR Signaling Pathway in Epstein-Barr Virus B Cell Lymphomas.
A. Sang, G. Ivison, C. Esquivel, S. Krams, O. Martinez.
Division of Abdominal Transplantation, Stanford School of Medicine, Stanford, CA.
Epstein-Barr virus (EBV) B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD) is a major problem in organ transplantation. Reduction of immunosuppression sometimes result in tumor…
2016 American Transplant Congress
Short UK Dialysis Does Not Significantly Impact on Live Donor Kidney Allograft Survival.
A. Bentall,^1,2 M. Jesky,^1,2 R. Borrows,^1,2 R. Johnson,³ S. Ball.^1,2
¹Department of Nephrology, University Hospitals Birmingham, Birmingham, United Kingdom; ²School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom; ³NHSBT, Bristol, United Kingdom.
Background. The survival advantage of pre-emptive transplantation (Pre-empTx) in live donor kidney transplantation (LDKTx) was reported by Meier-Kreische (Kidney International, 2000). Dialysis practices differ internationally…
2016 American Transplant Congress
Delayed Graft Function (DGF) Does Not Accelerate Progression of Fibrosis During the First Year After Deceased Donor Kidney Transplantation.
R. Heilman, I. Qaqish, M. Smith, H. Khamash, B. Kaplan, K. Reddy.
Mayo Clinic, Phoenix, AZ.
BackgroundOur aim was to study the impact of DGF on the progression of interstitial fibrosis during the first post-transplant year.MethodsWe included all patients who received…
2016 American Transplant Congress
Everolimus Decline Anti-ABO Blood Type Antibody Titer in Desensitization for ABO Incompatible Kidney Transplantation.
Y. Wada, N. Fukuzawa, H. Harada.
Kidney Transplantation Surgery, Sapporo City General Hospital, Sapporo, Hokkaido, Japan.
INTRODUCTION: The immoderate donor shortage and sophisticated desensitization protocols resulted in the explosive increase and great success of the ABO blood type incompatible kidney transplantation…
2016 American Transplant Congress
The Effect of Spironolactone on Calcineurininhibitor Induced Nephrotoxicity.
L. Mortensen,¹ H. Thiesson,¹ C. Bistrup,¹ F. Nielsen,³ U. Halekoh,² B. Jensen,³ N. Marcussen.⁴
¹Department of Nephrology, Odense University Hospital, Odense, Denmark; ²Department of Biostatistics, University of Southern Denmark, Odense, Denmark; ³Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; ⁴Department of Clinical Pathology, Odense University Hospital, Odense, Denmark.
Purpose: Evidence points towards activation of the mineralocorticoid receptor (MR) to be involved in CNI nephrotoxicity. The SPIREN trial was designed to test the hypothesis…
2016 American Transplant Congress
Belatacept Immunotherapy Is Not Augmented by Blockade of Activated LFA-1 in a Nonhuman Primate Renal Transplant Model.
K. Samy,¹ M. Mulvihill,¹ B. Collins,¹ D. Lo,² M. Song,¹ F. Leopardi,¹ A. Kirk.^1,2
¹Department of Surgery, Duke University Medical Center, Durham, NC; ²Emory University, Atlanta, GA.
Purpose: Belatacept specifically targets de novo alloimmune responses without off target side effects. However, resistant alloreactive memory T cells have complicated its use. LFA-1 therapy…
2016 American Transplant Congress
Dual Kidney Transplants as Policy to Optimize the Allocation of Marginal Donor Kidneys: Analysis of the French Cohort Since 2002.
E. Savoye,¹ R. Snanoudj,² C. Hiesse,³ M.-N. Peraldi,⁴ A. Durrbach,⁵ N. Ouali,⁶ M. Durand,⁷ L. Badet,⁸ M.-A. Macher.¹
¹Agence de la Biomédecine, Saint Denis, France; ²Necker hospital, Paris, France; ³Foch hospital, Suresnes, France; ⁴Saint Louis Hospital, Paris, France; ⁵Bicêtre Hospital, Kremlin Bicetre, France; ⁶Tenon hospital, Paris, France; ⁷Pasteur hospital Nice, Nice, France; ⁸Department of Chirurgie de la Transplantation Pav V and Department of Immunologie Clinique Transplantation Pav P, Edouard Herriot Hospital Group, Lyon, France.
The aim of this national multicentre cohort study was to assess the safety of dual kidney transplantation (DKT) in terms of patient and graft survival…
2016 American Transplant Congress
The Use of Kidneys with Acute Kidney Injury: The Good, the Bad and the Ugly.
C. Boffa,^1,2 F. van de Leemkolk,¹ E. Curnow,³ J. Gilbert,² E. Sharples,^1,2 R. Ploeg.^1,2
¹Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom; ²Oxford Transplant Centre, Oxford University Hospital Trust, Oxford, United Kingdom; ³Department of Statistics, NHS Blood and Transplant, Bristol, United Kingdom.
Introduction:The widening gap between supply and demand in kidney transplantation has lead to the increased use of kidneys from marginal donors, including those with acute…