Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Kidney transplantation is the best option for renal replacement therapy. One of its main limitations is the organs shortage. We analyzed the results in kidney transplants performed with organs from donors older than 80 years.
We studied 314 transplants between January 2010 and December 2014, 291 cadaver donors of which 288 first transplants; with a median follow up of 900 days. The histologic criteria for acceptance of organs was glomerulosclerosis <20%. Patients were classified by donor age into three groups: under 65 grafts (<65 ) ( 41.2 % ), between 65 and 80 ( 65-80 ) ( 40.5 %) and over 80 years ( > 80) ( 18.3%).We analyze donor's data: Age, gender, HTA, diabetes and creatinine (Cr) before extraction. Kidney data: Machine perfusion, cold ischemia time, glomerulosclerosis. Recipient data: HLA mismatches, creatinine in the first month and the first year after transplantation, acute tubular necrosis (ATN) , acute rejection and patient survival and graft.
The mean age was higher in patients receiving grafts from older donors. Cold ischemia was lower in patients <65 years (p = 0.048). There were no differences in ATN (23.9 % in <65. 65-80: 25.9 % and 7.8 %; in > 80 p = 0.8) or acute rejection of the first month (12, 1% overall, 14.5 % in < 65; 65-80: 11.6 % and 7.8 % in > 80 p = 0.46); or 1monhts Cr ( 1,85 in <65. 65-80: 2.18; and 2,06 in >80 P= 0,13); But it´s significance in the first year (1.58 in <65. 65-80: 1.9 and 1.76 in >80. P= 0.04).Mean graft survival was 90.1 % and 86 % a year and two years (91.3 % and 88.9 % in <65; 89.7 % and 84.9 % in 65-80 and 87.9 and 81.5 % in > 80. P = 0.25). In univariate analysis of graft survival we found significant differences in: HTA donors (p=0,059), ATN (P=0,004), and 1monhts Cr (P=0,004).
In multivariate cox analysis only ATN was related with graft lose; with a HR 2,86 (CI , 1.08 to 7,54 ).p<0,01
In our study, 18 % of donors were older than 80 years and the results in terms of renal function and survival are comparable to those given graft younger.
CITATION INFORMATION: Fernández A, González J, Galeano C, Elias S, Jimenez S, Caravaca F, Pampa S, Marcen R. The Use of Kidney Donors Older Than 80 Years Does Not Affect Graft Survival in the Medium Term. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Fernández A, González J, Galeano C, Elias S, Jimenez S, Caravaca F, Pampa S, Marcen R. The Use of Kidney Donors Older Than 80 Years Does Not Affect Graft Survival in the Medium Term. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/the-use-of-kidney-donors-older-than-80-years-does-not-affect-graft-survival-in-the-medium-term/. Accessed October 25, 2020.
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