Articles tagged "Calcineurin"

2017 American Transplant Congress
Impact of Belatacept Conversion on Kidney Transplant Function, Histology and Gene Expression.
P. Sanghi,¹ G. Gupta,¹ D. Kumar,¹ J. Reeve,² M. Levy,¹ A. Sharma,¹ H. Fattah,¹ P. Kimball,¹ H. Massey,¹ A. King,¹ P. Halloran.²
¹Virginia Commonwealth University, Richmond; ²Alberta Transplant Applied Genomics Center, Edmonton, Canada
Background: Belatacept (bela) might be an alternative to Calcineurin Inhibitors (CNI) in order to avoid presumed nephrotoxicity. In this study we assessed the impact of…
2017 American Transplant Congress
Long-Term Preservation of Renal Function in Liver Transplant Recipients with Rabbit Anti-Thymocyte Globulin Induction and Delayed Initiation of Calcineurin Inhibitors.
I. Bajjoka, A. Yaldo, C. Crombez, K. Brown, M. Abouljoud.
Transplant Institute, Henry Ford Health System, Detroit, MI
Methods: A single-center retrospective analysis of medical records of 989 liver transplant recipients from 2001-2010 were reviewed and evaluated for patients who received thymo induction…
2017 American Transplant Congress
Costimulatory Blockade in Delayed Graft Function.
J. Von Visger,¹ A. Diez,¹ U. Nori,¹ T. Pesavento,¹ R. Pelletier,² A. Rajab,² A. El Hinnawi,² H. Winters.³
¹Medicine, The Ohio State University, Columbus, OH; ²Surgery, The Ohio State University, Columbus, OH; ³Pharmacy, The Ohio State University, Columbus, OH
Background: Delayed graft function (DGF) contributes to higher risk of rejection, poorer graft survival, hospital length of stay (LOS), and other morbidities. Studies also suggest…
2017 American Transplant Congress
Changes in Urinary Neutrophil Gelatinase Associated Lipocalin Combined with Urine Cytokines and Microalbuminuria as Predictors for Interstitial Fibrosis and Tubular Atrophy in Kidney Transplantation: A Matched-Pair Tissue Cohort Study.
W. Chancharoenthana,¹ A. Leelahavanichkul,¹ S. Wattanatorn,¹ J. Issara-Amphorn,² Y. Avihingsanon,¹ K. Praditpornsilpa,¹ N. Townamchai.¹
¹Division of Nephrology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; ²Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Background: Late graft loss from interstitial fibrosis - tubular atrophy (IF/TA) continues to be the “Achilles' heel” of kidney transplantation (KT). Long-term calcineurin inhibitors (CNIs)…
2017 American Transplant Congress
Felodipine Diminishes Decline in Glomerular Filtration Rate in Lung Transplanted Patients Treated with Cyclosporine: A Randomized Placebo Controlled Trial.
M. Hornum,¹ M. Iversen,² P. Oturai,³ M. Andersen,² M. Zemtsovski,⁴ P. Bredahl,⁴ N. Bjarnason,² K. Christiansen,⁵ J. Carlsen,² C. Møller,⁶ B. Feldt-Rasmussen,¹ M. Perch.²
¹Nephrology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; ²Cardiology, Section for Lung Transplantation, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; ³Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; ⁴Cardiothoracic Anaesthesiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; ⁵Public Health, Section of Biostatics, University of Copenhagen, Copenhagen, Denmark; ⁶Cardiothoracic Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Background. Calcium channel blockers may ameliorate the decline in renal function caused by calcineurin inhibitors in lung transplant (LTX) recipients. We previously demonstrated a 47…
2017 American Transplant Congress
Variability in Tacrolimus Concentrations Across Pediatric Solid Organ Transplants.
S. Min,¹ T. Daljevic,¹ O. Lee,¹ M.-E. Alary,⁶ F. Murdoch,⁵ R. Parekh,¹ V. Ng,¹ D. Hebert,¹ L. Hamiwka,² T. Blydt-Hansen,³ V. Phan,⁴ P. Birk,³ U. Allen,¹ S. Urschel,⁵ CNTRP POSITIVE Research Group, B. Foster,⁶ S. Mital.¹
¹The Hospital for Sick Children, Toronto, Canada; ²Alberta Children's Hospital, Calgary, Canada; ³University of Winnipeg, Winnipeg, Canada; ⁴Université de Montréal, Motreal, Canada; ⁵Stollery Children's Hospital, Edmonton, Canada; ⁶McGill University, Montreal, Canada
PURPOSE: We characterized the evolution of out-of-range tacrolimus (TAC) concentrations and associated factors during 1 year following a pediatric solid organ transplant (SOT).METHODS: Heart, kidney…
2016 American Transplant Congress
Novel Nuclear Factor-κB Activation Inhibitor, Dehydroxymethylepoxyquinomicin, Prevents the Development of Chronic Cyclosporine Nephropathy in Rats.
S. Morita,¹ K. Shinoda,¹ S. Tamaki,¹ H. Kono,² Y. Kanno,³ K. Umezawa,⁴ K. Nakagawa,² M. Oya.¹
¹Urology, Keio University School of Medicine, Tokyo, Japan; ²Urology, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Chiba, Japan; ³Nephrology, Tokyo Medical University, Tokyo, Japan; ⁴Molecular Target Medicine Screening, Aichi Medical University, Nagakute, Aichi, Japan.
Purpose:The nephrotoxicity of the calcineurin inhibitors including cyclosporine is a major problem in the kidney transplantation. We investigated the effect of a novel nuclear factor-κB…
2016 American Transplant Congress
Genomic-Derived Markers to Identify Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients.
E. Rhone,¹ R. Gehrau,² S. Bontha,² P. Walker,³ C. Dumur,⁴ D. Maluf,² V. Mas.²
¹Pediatrics, University of Virginia, Charlottesville, VA; ²Surgery, University of Virginia, Charlottesville, VA; ³Nephropath, Little Rock, AR; ⁴Pathology, Virginia Commonwealth University, Richmond, VA.
Background:Calcineurin inhibitor nephrotoxicity (CNIT) is a well-known contributor to chronic allograft dysfunction in kidney transplant recipients (KTRs). Pediatric KTRs are particularly at risk given their…
2016 American Transplant Congress
Adding an Antimetabolite to a Calcineurin-Inhibitor-Based Immunosuppression Regimen Leads to Improved Native Renal Function After Liver Transplantation.
A. Karim, D. Conway, G. Leverson, J. Mezrich, L. Fernandez, A. D'Alessandro, D. Foley.
Surgery, University of Wisconsin, Madison, WI.
Background: Nephrotoxic side effects of calcineurin inhibitors (CNI) have been well established. The addition of anti-metabolites (AM) to CNI-based immunosuppression (IS) regimens has been proposed…
2016 American Transplant Congress
Tacrolimus Precision Medicine: Antibiotics Increase Intra-Patient Variability in Tacrolimus Trough Concentrations in Kidney Transplant Recipients.
Y. Zheng, J. Lee, A. Masand, D. Dadhania, M. Thangamani, M. Suthanthiran.
Medicine/Nephrology and Hyeprtension, Weill Cornell Medical College, New York, NY.
BACKGROUND. The gut microbiome impacts drug absorption, metabolism, and distribution and was recently shown to be associated with tacrolimus dosing requirements. Since antibiotics can alter…