2019 American Transplant Congress
Conversion from Tacrolimus Immediate Release to Tacrolimus Extended Release (Envarsus XR®): A Real World Cohort Highlighting Dosing Variability among Patients
*Purpose: Tacrolimus extended release (TacER) (Envarsus XR®) has become an attractive alternative to tacrolimus immediate release (TacIR) due to its once daily dosing scheme, favorable…2019 American Transplant Congress
Belatacept Conversion for Calcineurin Inhibitor-Associated Thrombotic Microangiopathy in Kidney Transplant Recipients
Nephrology Division, MGH, Boston, MA
*Purpose: Thrombotic Microangiopathy (TMA) in kidney transplant recipients is a serious complication that can cause graft loss. It can be associated with immunosuppressive medications such…2019 American Transplant Congress
Calcineurin Inhibitor Holiday for Management of Post Transplant Acute Kidney Injury
Nephrology, The Ottawa hospital, Ottawa, ON, Canada
*Purpose: Calcineurin inhibitors (CNI), despite dominating the armamentarium of post transplant medications, are associated with long term nephrotoxicity and also delayed recovery of renal function…2019 American Transplant Congress
Risk Factors for Initial Sub- and Supra-Therapeutic Tacrolimus Trough Levels in Renal Transplant Recipients
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Sub-therapeutic tacrolimus trough levels have been associated with increased risk of rejection in renal transplant recipients and supra-therapeutic levels with infectious risks and drug…2019 American Transplant Congress
Monitoring And Management Of Proteinuria Is Often Ignored In Patients Receiving mTOR Therapy Following Orthotopic Liver Transplantation
*Purpose: Use of mTOR inhibitors, such as Everolimus (EVL), in liver transplant (LT) patients continues to rise as the side effect profile becomes more evident.…2019 American Transplant Congress
Nephrotoxicity Caused by Calcineurin Inhibitors is Meditated by BAX, NOL3 and XIAP Apoptotic Genes Dysregulation
*Purpose: Calcineurin inhibitors (CNI) remain the most effective and widely used immunosuppressive agents in kidney transplantation. Nephrotoxicity is a major secondary effect, and renal biopsy…2019 American Transplant Congress
How and Why Dyrk1a is Required for Optimal Foxp3+ Treg Functions
Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: TCR-induced calcineurin phosphatase activation and subsequent Nfat dephosphorylation, leading to Nfat translocation to the nucleus, is a key event in conventional T cell activation.…2019 American Transplant Congress
Cardioprotective Effects of Pre-Operative Cyclosporine in Patients Undergoing Heart Transplantation
Duke University Hospital, Durham, NC
*Purpose: The purpose of this study is to determine if pre-operative cyclosporine (Cya) decreases the rate of primary graft dysfunction (PGD) in patients undergoing orthotopic…2019 American Transplant Congress
Mitochondrial Dysfunction and Metabolic Reprogramming: Critical Features of Cyclosporine A Nephrotoxicity
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Calcineurin inhibitors (CNIs) are potent immunosuppressants but over time contribute to allograft fibrosis. Clinical efforts to minimize or avoid CNI have not been uniformly…2019 American Transplant Congress
Calcineurin Inhibitors and Long-Term Outcomes of Kidney Transplantation from Thai Transplant Registry
Chulalongkorn University, Bangkok, Thailand
*Purpose: Calcineurin inhibitors (CNIs) have became the primary immunosuppressive medications (IS) for kidney transplantation (KT) in the current era. However, the long-term outcomes of KT…
American Transplant Congress abstracts