ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Tacrolimus Precision Medicine: Antibiotics Increase Intra-Patient Variability in Tacrolimus Trough Concentrations in Kidney Transplant Recipients.

Y. Zheng, J. Lee, A. Masand, D. Dadhania, M. Thangamani, M. Suthanthiran.

Medicine/Nephrology and Hyeprtension, Weill Cornell Medical College, New York, NY.

Meeting: 2016 American Transplant Congress

Abstract number: D243

Keywords: Calcineurin, Dosage, Drug interaction, Kidney transplantation

Session Information

Date: Tuesday, June 14, 2016

Session Name: Poster Session D: Poster Session II: Kidney Complications-Other

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • High Intra-Patient Variability in Tacrolimus Trough Blood Levels Increases the Risk of Death-Censored Graft Loss After Kidney Transplantation
  • Conversion from Immediate to Prolonged Release Tacrolimus Did Not Change Intra-Patient Variability in Renal Transplant Patients

BACKGROUND. The gut microbiome impacts drug absorption, metabolism, and distribution and was recently shown to be associated with tacrolimus dosing requirements. Since antibiotics can alter the gut microbiota, we investigated the hypothesis that antibiotics increase intra-patient variability in tacrolimus trough concentrations, an identified risk factor for kidney graft failure.

METHODS. We conducted a retrospective review of electronic medical records of 271 kidney transplant recipients who received their kidney transplants from January 2012 to June 2013 at our center. We collected data recording antibiotic therapy and tacrolimus trough concentrations. We divided the study cohort into 2 groups: subjects who received antibiotics during the first month of transplantation (Early Abx Group) and subjects who did not (No Early Abx Group) and evaluated whether the Early Abx Group had increased intra-patient variability in tacrolimus trough levels, as measured by standard deviation (SD) and coefficient of variation (CV), in the 3 weeks following post-transplant month 1.

RESULTS. Seventy (26%) of the 271 subjects received antibiotics during the first month of transplantation (Early Abx Group), and 201 (74%) did not (No Early Abx Group). During the three weeks following post-transplant month 1, the Early Abx Group had significantly more intra-patient variability in tacrolimus trough concentrations than the No Early Abx Group: SD: 2.5±1.3 mg/dL vs. 2.1±1.7 mg/dL, P=0.01, Wilcoxon rank sum test, respectively (Fig. 1A); CV: 28%±16% vs. 23±17%, P=0.01, Wilcoxon rank sum test, respectively (Fig. 1B). The mean±SD tacrolimus trough concentrations, however, were not significantly different between the two groups during the same time frame (8.8 ±1.6 vs. 8.9±1.8 mg/dL, P=0.68, Wilcoxon rank sum test) (Fig. 1C).

CONCLUSIONS. Our original finding that antibiotics increase inter-patient variability in tacrolimus trough concentrations highlights the need for close monitoring of tacrolimus trough concentrations after antibiotic administration.

CITATION INFORMATION: Zheng Y, Lee J, Masand A, Dadhania D, Thangamani M, Suthanthiran M. Tacrolimus Precision Medicine: Antibiotics Increase Intra-Patient Variability in Tacrolimus Trough Concentrations in Kidney Transplant Recipients. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Zheng Y, Lee J, Masand A, Dadhania D, Thangamani M, Suthanthiran M. Tacrolimus Precision Medicine: Antibiotics Increase Intra-Patient Variability in Tacrolimus Trough Concentrations in Kidney Transplant Recipients. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/tacrolimus-precision-medicine-antibiotics-increase-intra-patient-variability-in-tacrolimus-trough-concentrations-in-kidney-transplant-recipients/. Accessed February 28, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Left-Sided Donor Nephrectomy Predisposes Living Kidney Donors to Latent Adrenal Insufficiency with Symptoms of Fatigue and Inferior Quality of Life.
  • Home
  • Search
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.