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Articles tagged "Calcineurin"

  • 2016 American Transplant Congress

    IL-2 Therapy Restores the Impaired Function of Regulatory T Cells Induced by Calcineurin Inhibitors in Liver Transplantation.

    G. Whitehouse, E. Gray, S. Mastoridis, E. Kodela, A. Sanchez-Fueyo, M. Martinez-Llordella.

    Liver Science Department, King's College London, London, United Kingdom.

    CD4+CD25+FOXP3+ regulatory T cells (Tregs) have an essential role in immune regulation and constitute a key target for cellular immunotherapies in transplantation. IL-2 is critical…
  • 2016 American Transplant Congress

    The Effect of Spironolactone on Calcineurininhibitor Induced Nephrotoxicity.

    L. Mortensen,1 H. Thiesson,1 C. Bistrup,1 F. Nielsen,3 U. Halekoh,2 B. Jensen,3 N. Marcussen.4

    1Department of Nephrology, Odense University Hospital, Odense, Denmark; 2Department of Biostatistics, University of Southern Denmark, Odense, Denmark; 3Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; 4Department of Clinical Pathology, Odense University Hospital, Odense, Denmark.

    Purpose: Evidence points towards activation of the mineralocorticoid receptor (MR) to be involved in CNI nephrotoxicity. The SPIREN trial was designed to test the hypothesis…
  • 2016 American Transplant Congress

    Impact of Low Dose Tacrolimus with Everolimus Regimen on Renal Pathology and T-Regulatory Cells in Kidney Transplant.

    A. Shetty,1 T. Opas,1 J. Mathew,1 V. Mas,2 J. Leventhal,1 N. Sustento-Reodica,1 L. Gallon.1

    1Northwestern University, Feinberg School of Medicine, Chicago, IL; 2University of Virginia, Charlottesville, VA.

    Calcineurin inhibitors (CNI) serve as the cornerstone of immunosuppression (IS) after kidney transplant. However chronic CNI nephrotoxicity has been implicated in allograft dysfunction. We hypothesize…
  • 2016 American Transplant Congress

    Impact on Wound Healing Events After Early Conversion to Everolimus in De Novo Renal Transplant Recipients: 24-Month Results from the Randomized ELEVATE Study.

    B. Nashan,1 M. van der Giet,1 H. Holdaas,1 M. Zeier,1 J. Pascual,1 Y. Avihingsanon,1 P. Lopez,2 J. Aguilar-Sanchez,2 J. Kochuparampil,2 Z. Wang,3 J. Cruzado,1 J. De Fijter.1

    1ELEVATE Study Group, Hamburg, Germany; 2Novartis, Basel, Switzerland; 3Novartis Pharmaceutical Corporation, East Hanover.

    BackgroundWound healing events (WHE) are probably the most common type of post-transplant (Tx) surgical complication. Due to its antiproliferative properties, mammalian target of rapamycin inhibitors…
  • 2016 American Transplant Congress

    The Use of Sofosbuvir (SOF)-Containing Direct Antiviral Agents (DAA)-Based Regimens Requires Increase in Tacrolimus (Tac) Doses in Kidney Transplant (KT) Recipients with Hepatitis C Virus (HCV) Infection.

    N. Polanco Fernandez,1 A. García Santiago,1 M. Fernández Ruiz,2 R. Muñoz,3 C. Alvarez Vazquez,4 A. Hernandez,1 V. Mercado,1 E. González Monte,1 I. Fernández,3 J. Aguado,2 M. Praga,1 A. Andres.1

    1Nephrology, Hospital Universitario “12 de Octubre”, Madrid, Spain; 2Unit of Infectious Diseases, Hospital Universitario “12 de Octubre”, Madrid, Spain; 3Gastroenterology, Hospital Universitario “12 de Octubre”, Madrid, Spain; 4Biochemistry, Hospital Universitario “12 de Octubre”, Madrid, Spain.

    Background: The use of SOF-containing regimens based on NS5A inhibitors has not been shown interactions with Tac in liver transplant.Specific data on KT recipients are…
  • 2016 American Transplant Congress

    Prospective Randomized Study of a Steroid Free, Low Dose Tacrolimus with Everolimus Regimen in Kidney Transplant.

    A. Shetty, O. Traitanon, M. Ansari, J. Mathew, J. Leventhal, V. Mas, L. Gallon.

    Northwestern University, Chicago, IL; University of Virginia, Chicago, IL.

    Calcineurin inhibitors (CNI) serve as the cornerstone of immunosuppression (IS) after kidney transplant. However chronic CNI nephrotoxicity has been implicated in allograft dysfunction. We hypothesize…
  • 2015 American Transplant Congress

    Frequencies of CD4+25hiFoxp3+ T Cells in Long-Term Follow-Up of Sirolimus-Converted Kidney Transplant Recipients

    O. Traitanon,1,2 A. Alvarado,1 E. Tantisattamo,1,2 A. Shetty,1,2 M. Ansari,1,2 J. Mathew,1 J. Leventhal,1 V. Mas,3 L. Gallon.1,2

    1Comprehensive Transplant Center, Northwestern University, Chicago, IL; 2Medicine-Nephrology, Northwestern University, Chicago, IL; 3Surgery, University of Virginia, Charlottesville, VA.

    Background: Tacrolimus(TAC) and Sirolimus(SRL) are commonly used immunosuppressive drugs in kidney transplantation. SRL has been shown to induce the expansion of regulatory T cells in…
  • 2015 American Transplant Congress

    NK Cells of Kidney Transplant Recipients Show a Reduced Capacity to Produce Cytokines But Retain Their Cytotoxic Capacity

    U. Hoffmann,1 C. Neudoerfl,1 K. Daemen,1 J. Keil,1 C. Blume,2,3 F. Lehner,4 H. Haller,2 C. Falk.1,5

    1Inst. of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; 2Dept. of Nephrology and Hypertension, Hanover Medical School, Hanover, Germany; 3Inst. of Technical Chemistry, Leibniz University Hanover, Hanover, Germany; 4Dept. of General, Visceral, and Transplantation Surgery, Hanover Medical School, Hanover, Germany; 5German Center for Infection Research, Braunschweig, Germany.

    The role of NK cells in either graft rejection or tolerance induction is still discussed controversially. In order to clarify the effect of long-term immunosuppression…
  • 2015 American Transplant Congress

    "What's the Mileage?" Determining the Length of Time in Which Renal Function Returns to Pre-Calcineurin Discontinuation Levels in Patients With Interstitial Fibrosis

    A. Diez, J. Von Visger, U. Nori, T. Pesavento, M. Henry, E. Davies, R. Pelletier.

    The Ohio State University, Columbus.

    Calcineurin Inhibitors (CNI) use may be associated with progressive renal dysfunction. Clinical trials have shown that CNI minimization or discontinuation may aid in improvement in…
  • 2015 American Transplant Congress

    NFAT Regulated Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Recipients

    V. Tatapudi, A. Webber, C. Leung, F. Vincenti.

    Div. of Nephrology, Dept. of Medicine, University of California, San Francisco Medical Center, San Francisco, CA.

    Purpose of Study:To demonstrate that profiling kidney transplant recipients (KTR) on Tacrolimus (Tac) based immunosuppression based on quantitative analysis of NFAT (nuclear factor of activated…
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