Date: Sunday, April 30, 2017
Session Name: Poster Session B: Pediatric Liver Transplant - Clinical
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
PURPOSE: We characterized the evolution of out-of-range tacrolimus (TAC) concentrations and associated factors during 1 year following a pediatric solid organ transplant (SOT).
METHODS: Heart, kidney and liver transplant recipients were enrolled in the study. TAC concentrations at 36-48 hours post TAC, 7, 14, 30 days, 3 & 12 months post-transplant were captured. The association of time after transplant and organ type with out-of-target concentrations was analyzed.
RESULTS: 216 SOT recipients(83 heart, 65 kidney and 68 liver) were included. 77% had out-of-target at 36-48 hours(21% supra-therapeutic, 56% sub-therapeutic). By 1 year, 43% had out-of-target(35% supra-therapeutic, 8% sub-therapeutic). There was a decline in sub-therapeutic and an increase in supra-therapeutic with time (p<0.001). After adjusting for age, race and time, heart transplants had lower odds of sub-therapeutic (OR[CI]=0.53[0.37,0.76]) and higher odds of supra-therapeutic compared to kidney(OR[CI]=1.72[1.20,2.48]).
|Organ Type||Adjusted OR||95% CI||P|
|Overall out of range||Kidney||1.00|
CONCLUSION: SOT recipients have high variability in TAC levels during 1 year follow-up which varies by organ. Clinical and demographic factors partially account for the variability.
CITATION INFORMATION: Min S, Daljevic T, Lee O, Alary M.-E, Murdoch F, Parekh R, Ng V, Hebert D, Hamiwka L, Blydt-Hansen T, Phan V, Birk P, Allen U, Urschel S, CNTRP POSITIVE Research Group, Foster B, Mital S. Variability in Tacrolimus Concentrations Across Pediatric Solid Organ Transplants. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Min S, Daljevic T, Lee O, Alary M-E, Murdoch F, Parekh R, Ng V, Hebert D, Hamiwka L, Blydt-Hansen T, Phan V, Birk P, Allen U, Urschel S, Group CNTRPPOSITIVEResearch, Foster B, Mital S. Variability in Tacrolimus Concentrations Across Pediatric Solid Organ Transplants. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/variability-in-tacrolimus-concentrations-across-pediatric-solid-organ-transplants/. Accessed February 18, 2020.
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