ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Bone marrow transplantation"

  • 2018 American Transplant Congress

    Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4+ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation

    G. Dwyer,1 L. Mathews,1 A. Lucas,1 B. Blazar,2 H. Turnquist.1

    1Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Pediatrics, University of Minnesota, Minneapolis, MN.

    Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…
  • 2018 American Transplant Congress

    Long-Term Nonhuman Primate Renal Allograft Survival without Ongoing Immunosuppression in Recipients of Delayed Donor Bone Marrow Transplantation

    K. Hotta, T. Oura, A. Dehnadi, M. Matsunami, I. Rosales, R. Smith, R. Colvin, A. Cosimi, T. Kawai.

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.

    Background: We have previously reported induction of renal allograft tolerance in nonhuman primates following an initial post-transplant period of conventional immunosuppression (IS) using a nonmyeloablative…
  • 2018 American Transplant Congress

    A Novel Conditioning Approach to Establish Chimerism Using Manipulation of JAK-STAT Pathways

    H. Xu, A. Merchak, L. Kahn, A. Chhabra, Y. Wen, Y. Huang, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.

    Hematopoietic chimerism establishes donor-specific tolerance to solid organ allografts. Targeting recipient immune cells (T, NK cells and macrophages) can effectively reduce the dose of total…
  • 2018 American Transplant Congress

    Characterization of Renal Allograft Tolerance Induction via Transient Mixed Chimerism in Non-Human Primates

    H. Sasaki,1 C. Thaiss,1 T. Oura,1 A. Rosales,2 R. Smith,2 R. Colvin,2 B. Cosimi,1 T. Kawai.1

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston; 2Pathology, Massachusetts General Hospital, Boston.

    Background: We have previously reported long-term renal allograft tolerance after induction of transient mixed chimerism in non-human primates. However, some recipients developed late onset chronic…
  • 2018 American Transplant Congress

    Post-Transplant High Dose Cyclophosphamide Treatment Induces Thymus-Independent Immune Tolerance of Vascularized Composite Allografts via Complete Depletion of the Alloreactive TCR Repertoire.

    G. Furtmüller,1 B. Oh,1 J. Sidhom,2 M. Fryer,1 V. Malek,1 X. Zhou,1 D. Cooney,1 C. Brayton,3 J. Dodd-o,4 S. Ganguly,2 G. Raimondi,1 W. Lee,1 L. Luznik,2 G. Brandacher.1

    1Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD; 2Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD; 3Department for Comparative Pathobiology, Johns Hopkins University, Baltimore, MD; 4Department of Anesthesiology, Johns Hopkins University, Baltimore, MD.

    Background: Treatment with PT/Cy in the setting of combined donor bone marrow transplantation and VCA has shown encouraging results with regards to chimerism induction and…
  • 2018 American Transplant Congress

    CD4+CD25bright Regulatory T Cells Prevent Acute Xenogeneic GVHD

    Y. Huang, A. Merchak, H. Xu, A. Chhabra, A. Khalil, Y. Wen, M. Binion, M. Badder, L. Kahn, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.

    Graft-versus-host disease (GVHD) is a major complication and limitation to the broad application of hematopoietic stem cell transplantation. Cell therapy has emerged as a promising…
  • 2018 American Transplant Congress

    Low Intensity Conditioning Protocol for Inducing Chimerism-Based Tolerance in Non-Obese Diabetic Mice

    A. Chhabra, Y. Huang, H. Xu, A. Merchak, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.

    Type 1 diabetes is the most common chronic disease affecting children. Islet cell or pancreas transplantation offer the most physiologic approach to glucose homostasis. However…
  • 2018 American Transplant Congress

    Outcomes after Kidney Transplantation in Patients with AL Amyloid Following Autologous Stem Cell Transplantation

    V. Gutgarts,1,2 I. Jaffer Sathick,2 C. Rosenbaum,3 T. Muthukumar,1 H. Hassoun,4 C. Flombaum,2 H. Landau.4

    1Nephrology, Weill Cornell, NY; 2Renal Medicine, Memorial Sloan Kettering, NY; 3Hematology, Weill Cornell, NY; 4Hematology, Memorial Sloan Kettering, NY.

    BackgroundAL amyloidosis results in kidney failure in about 15-30% of patients and is considered a relative contraindication for kidney transplantation. There is limited data on…
  • 2018 American Transplant Congress

    A Novel Protocol to Improve Kidney Transplant Outcomes in Patients with Renal Disease Due to Amyloidosis

    A. Langone, B. Concepcion, D. Slosky, R. Cornell, S. Horst, S. Goodman.

    Vanderbilt University Medical Center, Nashville, TN.

    In 2011, members from 10 different medical disciplines formed the Vanderbilt Amyloid Multidisciplinary Program (VAMP) in an effort to improve regional recognition of this rare…
  • 2018 American Transplant Congress

    Building a Third-Party VST Bank from Scratch- The Cincinnati Experience

    A. S. Nelson,1 D. Heyenbruch,2 X. Zhu,3 S. M. Davies,1 C. Lutzko,3 C. Bollard,4 P. Hanley,4 T. Leemhuis,2 L. Danziger-Isakov,5 M. S. Grimley.1

    1Bone Marrow Transplant & Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 2Hoxworth Blood Center, Univeristy of Cincinnati, Cincinnati, OH; 3Experimental Hematology & Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 4Proram for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System, Washington, DC; 5Depatment of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

    BackgroundViral infections remain a challenge to treat and significantly contribute to morbidity and mortality. Virus specific T cells (VSTs) have shown clinical efficacy, with minimal…
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