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American Transplant Congress abstracts

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Articles tagged "Bone marrow transplantation"

  • 2018 American Transplant Congress

    A Novel Protocol to Improve Kidney Transplant Outcomes in Patients with Renal Disease Due to Amyloidosis

    A. Langone, B. Concepcion, D. Slosky, R. Cornell, S. Horst, S. Goodman.

    Vanderbilt University Medical Center, Nashville, TN.

    In 2011, members from 10 different medical disciplines formed the Vanderbilt Amyloid Multidisciplinary Program (VAMP) in an effort to improve regional recognition of this rare…
  • 2018 American Transplant Congress

    Building a Third-Party VST Bank from Scratch- The Cincinnati Experience

    A. S. Nelson,1 D. Heyenbruch,2 X. Zhu,3 S. M. Davies,1 C. Lutzko,3 C. Bollard,4 P. Hanley,4 T. Leemhuis,2 L. Danziger-Isakov,5 M. S. Grimley.1

    1Bone Marrow Transplant & Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 2Hoxworth Blood Center, Univeristy of Cincinnati, Cincinnati, OH; 3Experimental Hematology & Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 4Proram for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System, Washington, DC; 5Depatment of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

    BackgroundViral infections remain a challenge to treat and significantly contribute to morbidity and mortality. Virus specific T cells (VSTs) have shown clinical efficacy, with minimal…
  • 2018 American Transplant Congress

    RNA Expression Profiling of Renal Allografts in a Non-Human Primate Identifies Inflammation as a Risk Factor in Chronic Antibody Mediated Rejection

    R. Smith,1 B. Adam,2 A. Rosales,1 M. Matsunami,3 T. Oura,3 B. Cosimi,3 T. Kawai,3 M. Mengel,2 R. Colviin.1

    1Pathology, Massachusetts General Hospital, Boston, MA; 2Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 3Surgery, Massachusetts General Hospital, Boston, MA.

    IntroductionChronic alloantibody mediated rejection (CAMR) is a major risk factor in renal allografts. Some inflammation is commonly identified within CAMR, though mostly low grade, and…
  • 2018 American Transplant Congress

    RNA Expression Profiling of Renal Allografts in the Cynomolgus Monkey Identifies Tolerance

    R. Smith,1 M. Matsunami,3 B. Adam,2 A. Rosales,1 T. Oura,3 A. Cosimi,3 T. Kawai,3 M. Mengel,2 R. Colvin.1

    1Pathology, Massachusetts General Hospital, Boston, MA; 2Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 3Department of Surgery, Massachusetts General Hospital, Boston, MA.

    IntroductionTolerance induction is a long standing clinical goal. However, identification remains elusive. Here we profile intra-renal allograft RNA expression in a mixed chimerism renal allograft…
  • 2018 American Transplant Congress

    Relationship between Mixed Chimerism and Acceptance of HLA-Matched and Mismatched Kidney Transplants after Withdrawal of Immunosuppressive Drugs

    J. Scandling, S. Busque, R. Lowsky, J. Shizuru, K. Jensen, A. Shori, E. Engleman, E. Meyer, R. Hoppe, S. Strober.

    Stanford University, Stanford, CA.

    Classical studies in cattle and rodents showed that mixed chimerism (MXC) established in fetuses and neonates was permanent, linked to immune tolerance and graft acceptance…
  • 2018 American Transplant Congress

    Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients

    J. Leventhal,1 J. Galvin,1 J. Mathew,1 L. Gallon,1 D. Stare,1 K. Kurtenbach,1 K. Ravindra,3 M. Horwitz,3 J. Miller,1 M. Abecassis,1 S. Ildstad.2

    1Surgery, Northwestern U, Chicago; 2U of Louisville, Louisville; 3Duke U, Durham.

    37 pts have been transplanted in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The protocol is based…
  • 2018 American Transplant Congress

    Immunity and Tolerance after Bilateral Orthotopic Lung Transplant (BOLT) in Tandem with a CD3+/CD19+ Depleted Vertebral Bone Marrow Transplant (BOLT+BMT) from 1 of 8 HLA-Matched Cadaveric Donors

    P. Szabolcs,1 X. Chen,1 A. Donnenberg,2 M. Hill,1 J. Rowan,1 S. Mcintyre,1 G. Kurland,1 J. Barnum,1 J. McDyer.1

    1BMT-CT, Children Hospital of Pittsburgh UPMC, Pittsburgh, PA; 2IDM-HCC, University of Pittsburgh, Pittsburgh, PA.

    Primary immunodeficiency patients may develop pulmonary complications and most are ineligible for either lung transplant or BMT due to futility. We report our first 2…
  • 2018 American Transplant Congress

    Changes in Phenotype, Immune Suppressive, Function, and Gene Expression of Myeloid Derived Suppressor Cells in Patients Given Combined Kidney and Hematopoietic Cell Transplants in a Tolerance Protocol

    K. Jensen,1 P. Zheng,2 J. Xuhuai,2 A. Saraswathula,1 J. Scandling,3 S. Busque,4 J. Shizuru,5 R. Lowsky,5 A. Shori,4 H. Maecker,2 E. Engleman,1 E. Meyer,5 S. Strober.1

    1Immunology, Stanford School of Medicine, Stanford, CA; 2Human Immune Monitoring Center, Stanford School of Medicine, Stanford, CA; 3Nephrology, Stanford School of Medicine, Stanford, CA; 4Surgery, Stanford School of Medicine, Stanford, CA; 5Blood & Marrow Transplantation, Stanford School of Medicine, Stanford, CA.

    Tolerance induction after combined organ and hematopoietic cell transplantation can be achieved using conditioning with total lymphoid irradiation (TLI) and anti-thymocyte globulin (ATG), in both…
  • 2018 American Transplant Congress

    Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4+ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation

    G. Dwyer,1 L. Mathews,1 A. Lucas,1 B. Blazar,2 H. Turnquist.1

    1Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Pediatrics, University of Minnesota, Minneapolis, MN.

    Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…
  • 2018 American Transplant Congress

    Long-Term Nonhuman Primate Renal Allograft Survival without Ongoing Immunosuppression in Recipients of Delayed Donor Bone Marrow Transplantation

    K. Hotta, T. Oura, A. Dehnadi, M. Matsunami, I. Rosales, R. Smith, R. Colvin, A. Cosimi, T. Kawai.

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.

    Background: We have previously reported induction of renal allograft tolerance in nonhuman primates following an initial post-transplant period of conventional immunosuppression (IS) using a nonmyeloablative…
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