ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Bone marrow transplantation"

  • 2021 American Transplant Congress

    Cmv Specific Cellmediated Immune Reconstitution During Letermovir Prophylaxis in High Risk Hematopoietic Cell Transplant Recipients

    M. Abidi1, J. Gutman2, A. Weinberg2

    1University of Colorado Denver/Anschutz Medical Campus, Aurora, CO, 2University of Colorado Denver, Denver, CO

    *Purpose: Patients who are cytomegalovirus (CMV) seropositive (R+) prior to hematopoietic cell transplant (HCT), have a 30% incidence of clinically significant CMV reactivation in the…
  • 2021 American Transplant Congress

    Successful Induction of Hematopoietic Chimerism by Dual Inhibition of Mcl-1 and Bcl-2 Without Myeloablative Treatments in Nonhuman Primates

    T. Hirose, D. Ma, G. Lassiter, T. Kawai

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: Induction of hematopoietic chimerism by donor bone marrow transplantation (BMT) is essential for achievement of allograft tolerance in clinical HLA mismatched kidney transplantation, while…
  • 2021 American Transplant Congress

    Eosinophils Attenuate Hepatic Ischemia Reperfusion Injury in Mice Through St2-Dependent Il-13 Production

    Y. Yang, Y. Wang, M. Wang, J. Jeong, L. Xu, Y. Wen, C. Emontzpohl, W. Dar, C. Ju

    Department of Anesthesiology, McGovern Medical School University of Texas Health Science Center at Houston, Houston, TX

    *Purpose: The purpose is to investigate the functional role of eosinophils during hepatic ischemia and reperfusion injury (IRI).*Methods: Mice with antibody-induced eosinophil depletion and two…
  • 2021 American Transplant Congress

    Harnessing Innate Lymphoid Cells to Prevent Graft-versus Host Disease

    K. T. Reid1, S. Q. Crome2

    1Immunology, University of Toronto, Toronto, ON, Canada, 2Ajmera Transplant Centre, TGHRI, University Health Network, Toronto, ON, Canada

    *Purpose: Determine whether human innate lymphoid cells (ILCs) can be isolated, expanded and used in cell-based therapies to prevent Graft-versus Host Disease (GvHD) .*Methods: ILC2s…
  • 2020 American Transplant Congress

    Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients

    J. Leventhal1, J. Mathew1, J. Galvin2, L. Gallon1, D. Belshe1, K. Ravindra3, M. Horwitz3, J. Miller1, S. Ildstad4

    1Northwestern, Chicago, IL, 2UIC, Chicago, IL, 3Duke, Durham, NC, 4U Louisville, Louisville, KY

    *Purpose: 37 pts have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The…
  • 2020 American Transplant Congress

    Orthogonal IL-2 Cytokine-Receptor Pair Capable of Selective Expansion of Regulatory T Cells Facilitates Alloengraftment

    T. Hirai1, F. Simonetta2, L. L. Su3, L. Picton3, J. Baker2, J. Lin4, P. Li4, W. J. Leonard4, K. C. Garcia3, R. S. Negrin2

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA, 3Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA, 4Laboratory of Molecular Immunology, National Institutes of Health, Bethesda, MD

    *Purpose: Adoptive transfer of regulatory T cells (Tregs) has been shown to improve alloengraftment in animal models. However, ex vivo Treg expansion for the purpose…
  • 2020 American Transplant Congress

    Hepatitis B Virus Prophylaxis and Treatment among Hematopoietic Stem Cell Transplant Recipients: Impact on Engraftment and Outcomes

    B. Buzo1, J. Fernandes Ramos2, R. Marques Rossetti3, N. Salles4, A. Mendrone-Junior4, V. Rocha3, A. de Seixas Santos Nastri5

    1Division of Infectious Diseases, University of Alberta, Edmonton, AB, Canada, 2Division of Infectious Diseases and Division of Hematology, University of Sao Paulo, Sao Paulo, Brazil, 3Division of Hematology, University of Sao Paulo, Sao Paulo, Brazil, 4Fundacao Pro-Sangue, Sao Paulo, Brazil, 5Division of Infectious Diseases, University of Sao Paulo, Sao Paulo, Brazil

    *Purpose: Hepatitis B virus infection is a worldwide concern with a broad distribution. It can reactivate in immunocompromised populations such as solid organ and hematopoietic…
  • 2020 American Transplant Congress

    Cardiac Allograft Tolerance Can be Achieved in Non-Human Primates via Transient Mixed Hematopoietic Chimerism and Erythropoietin Administration

    K. Ahrens1, J. M. O1, W. Sommer2, J. Morrissette1, D. Becerra1, P. M. Patel1, A. Dehnadi1, T. Costa1, I. M. Hanekamp1, J. S. Allan3, P. Cravedi4, P. S. Heeger4, G. Benichou1, J. C. Madsen5

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, 4Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 5Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: In non-human primates (NHPs), a mixed chimerism-based conditioning protocol results in kidney transplant tolerance and combined kidney and heart allograft tolerance. Previous work showed…
  • 2020 American Transplant Congress

    Efficacy and Tolerability of Tedizolid Phosphate in the Treatment of Mycobacterium Abscessus Infection among Pediatric Hematopoietic Stem Cell Transplant Recipients

    Y. Kang, V. M. Aquino, A. Y. Koh, D. Wetzel, P. K. Sue

    Pediatrics, UT Southwestern Medical Center, Dallas, TX

    *Purpose: Mycobacterium abscessus complex infections are associated with high rates of morbidity and mortality in immunocompromised hosts. Treatment can be challenging due to broad spectrum…
  • 2020 American Transplant Congress

    Kidney Transplantation after Multiple Myeloma: The Last 2 Decades

    V. Nair, K. Jhaveri, M. Abate

    Medicine, Northwell Health, Manhasset, NY

    *Purpose: Due to recent advances, patients with a history of multiple myeloma (MM) and ESKD are more frequently offered kidney transplantation (Ktx). Existing literature does…
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