Articles tagged "Biopsy"

2016 American Transplant Congress
Standardized Pre-Implantation Kidney Biopsies of Expanded Criteria Donors to Improve the Kidney Donor Profile Index (KDPI) for the Evaluation of Marginal Donors.
A. Sánchez-Escuredo,¹ A. Sagasta,² F. Diekmann,¹ I. Revuelta,¹ L. Rodas,¹ D. Paredes,³ M. Musquera,⁴ N. Esforzado,¹ M. Ricart,¹ F. Cofan,¹ V. Torregrosa,¹ J. Campistol,¹ M. Sole,² F. Oppenheimer.¹
¹Nephrology and Renal Transplant, Hospital Clínic, Barcelona, Spain; ²Pathology, Hospital Clínic, Barcelona, Spain; ³Transplant Foundation, Hospital Clínic, Barcelona, Spain; ⁴Urology, Hospital Clínic, Barcelona, Spain.
There is no consensus of selection criteria used to allocate renal transplants from expanded criteria donors (ECD). The Kidney Donor Profile Index (KDPI) has been…
2016 American Transplant Congress
Chronic Infection by Hepatitis C Virus and the Development of Transplant Glomerulopathy.
D. Regidor,¹ S. Alexandru,⁵ M. Martínez,³ N. Polanco,⁴ E. González,⁴ A. Serrano,² J. Morales.⁴
¹Nephrology, H.Virgen de la Salud, Toledo, Spain; ²Immunology, Instituto de Investigación H. Doce de Octubre, Madrid, Spain; ³Pathology, H.Doce de Octubre, Madrid, Spain; ⁴Nephrology, H.Doce de Octubre, Madrid, Spain; ⁵Nephrology, H.Rey Juan Carlos, Madrid, Spain.
OBJETIVE: To demonstrate that chronic infection with the hepatitis C virus (HCV) is a risk factor for the development of transplant glomerulopathy in a large…
2016 American Transplant Congress
Predictors of Early Rejection and Allograft Failure in Pediatric Kidney Transplantation: Impact of Histology and Behavior.
M. Seifert, M. Yanik, R. Mannon.
University of Alabama at Birmingham School of Medicine, Birmingham.
Background: Early inflammatory events that lead to allograft dysfunction are often missed by creatinine-based estimates in children. Surveillance biopsies can detect early allograft dysfunction due…
2016 American Transplant Congress
Mapping Heterogeneity in Antibody-Mediated Rejection Using Molecular Phenotypes and Archetype Analysis.
J. Reeve,¹ P. Halloran.^1,2
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada; ²Medicine, University of Alberta, Edmonton, AB, Canada.
Archetype analysis is a method for identifying new relationships among samples without subdividing them into classes, finding a limited number of archetypical cases and calculating…
2016 American Transplant Congress
Interaction Between Kidney Tissue Proteome and Humoral Immunity in Antibody Mediated Rejection.
A. Konvalinka,¹ A. Chruscinski,² S. Kim,¹ K. Tinckam,¹ I. Jurisica,³ R. John.⁴
¹Medicine/Division of Nephrology, Toronto General Hospital, Toronto, ON, Canada; ²Medicine/Division of Cardiology, Toronto General Hospital, Toronto, ON, Canada; ³Medical Biophysics and Computational Science, University of Toronto, Toronto, ON, Canada; ⁴Pathology, Toronto General Hospital, Toronto, ON, Canada.
PURPOSE: Antibody-mediated rejection (AMR) is caused by antibodies against human leukocyte antigens (HLA) on graft endothelium, and non-HLA antibodies that target endothelial and epithelial proteins.…
2016 American Transplant Congress
Role of Natural Killer Cells in Kidney Transplant Outcome.
E. Carta,¹ R. Littera,² M. Murgia,¹ M. Michittu,¹ B. Onano,¹ G. Piredda,¹ D. Argiolas.¹
¹Renal Transplant Unit, Azienda Brotzu, Cagliari, Italy; ²Regional Transplant Coordination, ASL 8, Cagliari, Italy.
Aim of the study was to evaluate the relationship between killer cell immunoglobulin-like receptor (KIR) phenotype and kidney transplant rejection. NK-target cell interaction depends on…
2016 American Transplant Congress
Microarray Analysis of Transbronchial and Mucosal Biopsies in Lung Transplant Recipients Detects Molecular Changes of T-Cell Mediated Inflammation.
K. Halloran,¹ J. Chang,² V. Ramassar,² J. Weinkauf,¹ A. Kapasi,¹ D. Lien,¹ J. Reeve,² P. Halloran.^1,2
¹Medicine, University of Alberta, Edmonton, Canada; ²Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada.
Purpose: The main diagnostic platform for rejection in lung transplant recipients is histology of transbronchial biopsies (TBB), a test with a poor performance and safety…
2016 American Transplant Congress
Criteria for the Diagnosis of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx).
J. Grande,¹ R. Leduc,² The DeKAF Study Group.
¹Dept. of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; ²Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.
The presence of MVI (Banff glomerulitis "g" score and Banff peritubular capillary "ptc" score) in KTxBx, often related to antibody mediated rejection (AMR), is associated…
2016 American Transplant Congress
Results of Biopsies in Pancreas and Kidney-Pancreas Patients with Graft Dysfunction.
P. Uva, L. Leon, E. Minue, I. Cabrera, A. Giunippero, M. Norese, M. Toniolo, E. Chuluyan, D. Casadei.
Nephrology, Buenos Aires, Argentina.
In pancreas transplantation there is no reliable laboratory test or imaging study for detection of graft rejection. There is an increasing interest in obtaining pancreas…
2016 American Transplant Congress
Management and Outcomes of Upper Extremity Deep Venous Thrombosis in Heart Transplant Patients.
A. Panakos,¹ D. Kramer,¹ M. McCarey,¹ P. Mather.²
¹Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA; ²Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA.
Upper extremity deep venous thrombosis (UEDVT) is common in post-heart transplant (OHT) patients, likely due to their multiple intravascular catheters and post-surgical state. The clinical…