ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Biopsy"

  • 2016 American Transplant Congress

    Glomerular Capillary C4d Staining without Evidence of Rejection Is Associated with Worse Graft Function in ABO-Incompatible Kidney Transplantation.

    D. Toki,1 M. Inui,1 M. Okumi,2 H. Ishida,2 K. Setoguchi,1 T. Shimizu,2 K. Unagami,2 K. Tanabe.2

    1Urology, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan; 2Urology, Tokyo Women's Medical University, Tokyo, Japan.

    Objectives: C4d staining in the peritubular capillaries (C4d-PTC) is often observed without evidence of rejection in ABO-incompatible kidney transplantation (ABOI-KTx), and this phenomenon is generally…
  • 2016 American Transplant Congress

    Long-Term Death-Censored Graft Loss in the DeKAF Study.

    A. Matas,1 A. Fieberg,1 R. Leduc,1 F. Cosio,2 R. Gaston,3 R. Mannon,3 M. Cecka,4 D. Rush,7 B. Kasiske,5 S. Gourishankar,6 J. Connett,1 J. Grande.2

    1U of MN, Mpls, MN; 2Mayo, Rochester, MN; 3UAB, Birmingham, AB; 4UCLA, LA, CA; 5HCMC, Mpls, MN; 6U Alberta, Edmonton, AB, Canada; 7UMB, Winnipeg, MB, Canada.

    The aim of the Deterioration of Kidney Allograft Function study (DeKAF) was to identify and assess the pathologies of troubled kidney grafts, that is, those…
  • 2016 American Transplant Congress

    Urinary Exosomal Annexin A1 Is a Predictive Biomarker of Post Kidney Transplant Complications.

    H. Harada,1 T. Murakami,2 C. Yamamoto,2 K. Hotta,1 N. Fukuzawa,1 M. Mitsuhashi.2

    1Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan; 2Hitachi Chemical Co. America, Ltd., Irvine, CA; 3Nanosomix, Inc., Aliso Viejo, CA.

    IntroductionMonitoring of kidney allograft condition is important. We had exhibited non-invasive diagnostic modality of post-kidney transplant complications using urine exosomal and microvesicule (EMV) mRNA of…
  • 2016 American Transplant Congress

    Characterization of Vascular Lesions in Living Donor Renal Transplant Implant Biopsies.

    F. Tinney Jr,1 L. Yessayan,2 M. Abouljoud,3 A. Patel.3

    1Wayne State University School of Medicine, Detroit, MI; 2Department of Nephrology, Henry Ford Hospital, Detroit, MI; 3Transplant Institute, Henry Ford Hospital, Detroit, MI.

    INTRODUCTION: Nephrosclerosis is often associated with pathological injury to kidneys resulting from chronic high blood pressure and/or aging, and may predict the progression of decline…
  • 2016 American Transplant Congress

    A Molecular Biopsy Test for Probability of Non-Adherence.

    P. Halloran,1,3 G. Einecke,2 J. Reeve.1

    1ATAGC, Edmonton, AB, Canada; 2Hannover Medical School, Hannover, Germany; 3Department of Medicine, University of Alberta, Edmonton, AB, Canada.

    Afferent arteriolar hyalinosis (ah-score) in renal transplant biopsies increases with time of biopsy-post-transplant (TxBx), reflecting calcineurin inhibitor drug effects, donor aging, and progressive glomerular diseases.…
  • 2016 American Transplant Congress

    A Quantitative CD45 Immunohistochemical Assay Allows Precise and Reproducible Measurement of Inflammation in Renal Transplant Biopsies.

    V. Walavalkar,1 S. Bowman,1 L. Laszik,1 D. Ikle,2 S. Chandran,1 F. Vincenti,1 Z. Laszik.1

    1UCSF, San Francisco, CA; 2Rho, Chapel Hill, NC.

    Purpose: Total inflammation (TI) is an important variable for the pathologic work-up of transplant kidney biopsies (TxBx) in the Banff schema. However, current standard pathologic…
  • 2016 American Transplant Congress

    Clinical Outcomes of Kidney Allograft Recipients with Apolipoprotein L1 (APOL1) Risk Alleles from Living Kidney Donors.

    C. Dorr,1,2,3 A. Hart,1,2,3 D. Schladt,1 A. Muthusamy,1 R. Mannon,4 W. Oetting,2 A. Matas,2 P. Jacobson,2 A. Israni.1,2,3

    1Minneapolis Medical Research Foundation, Minneapolis; 2University of Minnesota, Minneapolis; 3Hennepin County Medical Center, Minneapolis; 4University of Alabama, Birmingham.

    Background:Apolipoprotein L1 (APOL1) alleles G1 and G2 in deceased donors are associated with poor kidney allograft survival. However, the effect of these alleles in living…
  • 2016 American Transplant Congress

    De Novo Anti-HLA DSA Characteristics and Subclinical Antibody Mediated Kidney Allograft Injuries.

    T. Yamamoto, Y. Watarai, A. Takeda, M. Okada, M. Tsujita, T. Hiramitsu, N. Goto, S. Narumi, K. Morozumi, K. Uchida, T. Kobayashi.

    Nagoya daini red cross hospital, Nagoya, Japan.

    Background It has been reported that de novo donor-specific HLA antibody (dn DSA) production is associated with chronic antibody-mediated rejection (CAMR) which leads to poor…
  • 2016 American Transplant Congress

    Biopsies for Delayed Graft Function After Alemtuzumab Induction in Kidney Transplantation: The Incidence of Early Rejection After Alemtuzumab Is Very Low but Not Negligible.

    E. McGuire, C. Roufosse, T. Cook, D. Ashby, T. Cairns, J. Galliford, M. Willicombe, D. Taube, A. McLean.

    Imperial Kidney & Transplant Centre, Hammersmith Hospital, Imperial College Healthcare, London, United Kingdom.

    IntroductionUK practice advocates transplant biopsy (Bx) at day 7, then weekly in the presence of delayed graft function (DGF) because if missed, early rejection adversely…
  • 2016 American Transplant Congress

    Acute Rejection by Belatacept (Bela) Dosing Frequency: Results from a Phase II Study of Kidney Transplant Recipients.

    F. Vincenti,1 G. Blancho,2 A. Durrbach,3 G. Grannas,4 J. Grinyó,5 U. Meier-Kriesche,6 M. Polinsky,6 H. Zhao,6 C. Larsen.7

    1UCSF, San Francisco, CA; 2University Hospital of Nantes, Nantes, France; 3University Hôpital of Bicêtre, Le Kremlin-Bicêtre, France; 4Medizinische Hochschule Hannover, Hannover, Germany; 5University Hospital of Bellvitge, Bellvitge, Spain; 6Bristol-Myers Squibb, Lawrenceville, NJ; 7Emory University Transplant Center, Atlanta, GA.

    Background: At 1 year post transplant in IM103-100 (NCT00035555), bela-treated patients had similar acute rejection (AR) rates and significantly improved renal function vs cyclosporine A…
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