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Articles tagged "Biopsy"

  • 2016 American Transplant Congress

    Predictors of Early Rejection and Allograft Failure in Pediatric Kidney Transplantation: Impact of Histology and Behavior.

    M. Seifert, M. Yanik, R. Mannon.

    University of Alabama at Birmingham School of Medicine, Birmingham.

    Background: Early inflammatory events that lead to allograft dysfunction are often missed by creatinine-based estimates in children. Surveillance biopsies can detect early allograft dysfunction due…
  • 2016 American Transplant Congress

    Mapping Heterogeneity in Antibody-Mediated Rejection Using Molecular Phenotypes and Archetype Analysis.

    J. Reeve,1 P. Halloran.1,2

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada; 2Medicine, University of Alberta, Edmonton, AB, Canada.

    Archetype analysis is a method for identifying new relationships among samples without subdividing them into classes, finding a limited number of archetypical cases and calculating…
  • 2016 American Transplant Congress

    Interaction Between Kidney Tissue Proteome and Humoral Immunity in Antibody Mediated Rejection.

    A. Konvalinka,1 A. Chruscinski,2 S. Kim,1 K. Tinckam,1 I. Jurisica,3 R. John.4

    1Medicine/Division of Nephrology, Toronto General Hospital, Toronto, ON, Canada; 2Medicine/Division of Cardiology, Toronto General Hospital, Toronto, ON, Canada; 3Medical Biophysics and Computational Science, University of Toronto, Toronto, ON, Canada; 4Pathology, Toronto General Hospital, Toronto, ON, Canada.

    PURPOSE: Antibody-mediated rejection (AMR) is caused by antibodies against human leukocyte antigens (HLA) on graft endothelium, and non-HLA antibodies that target endothelial and epithelial proteins.…
  • 2016 American Transplant Congress

    Role of Natural Killer Cells in Kidney Transplant Outcome.

    E. Carta,1 R. Littera,2 M. Murgia,1 M. Michittu,1 B. Onano,1 G. Piredda,1 D. Argiolas.1

    1Renal Transplant Unit, Azienda Brotzu, Cagliari, Italy; 2Regional Transplant Coordination, ASL 8, Cagliari, Italy.

    Aim of the study was to evaluate the relationship between killer cell immunoglobulin-like receptor (KIR) phenotype and kidney transplant rejection. NK-target cell interaction depends on…
  • 2016 American Transplant Congress

    Microarray Analysis of Transbronchial and Mucosal Biopsies in Lung Transplant Recipients Detects Molecular Changes of T-Cell Mediated Inflammation.

    K. Halloran,1 J. Chang,2 V. Ramassar,2 J. Weinkauf,1 A. Kapasi,1 D. Lien,1 J. Reeve,2 P. Halloran.1,2

    1Medicine, University of Alberta, Edmonton, Canada; 2Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada.

    Purpose: The main diagnostic platform for rejection in lung transplant recipients is histology of transbronchial biopsies (TBB), a test with a poor performance and safety…
  • 2016 American Transplant Congress

    Criteria for the Diagnosis of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx).

    J. Grande,1 R. Leduc,2 The DeKAF Study Group.

    1Dept. of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; 2Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.

    The presence of MVI (Banff glomerulitis "g" score and Banff peritubular capillary "ptc" score) in KTxBx, often related to antibody mediated rejection (AMR), is associated…
  • 2016 American Transplant Congress

    Results of Biopsies in Pancreas and Kidney-Pancreas Patients with Graft Dysfunction.

    P. Uva, L. Leon, E. Minue, I. Cabrera, A. Giunippero, M. Norese, M. Toniolo, E. Chuluyan, D. Casadei.

    Nephrology, Buenos Aires, Argentina.

    In pancreas transplantation there is no reliable laboratory test or imaging study for detection of graft rejection. There is an increasing interest in obtaining pancreas…
  • 2016 American Transplant Congress

    Management and Outcomes of Upper Extremity Deep Venous Thrombosis in Heart Transplant Patients.

    A. Panakos,1 D. Kramer,1 M. McCarey,1 P. Mather.2

    1Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA; 2Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA.

    Upper extremity deep venous thrombosis (UEDVT) is common in post-heart transplant (OHT) patients, likely due to their multiple intravascular catheters and post-surgical state. The clinical…
  • 2016 American Transplant Congress

    Comparison of C4d Deposition in Renal Biopsies with Luminex-Based C3d Single Antigen Bead (SAB) Detection.

    R. Pelletier,1 I. Balazs,2 P. Adams,3 P. Steller,3 N. DiPaola,4 L. Rankin,3 A. Diez,5 M. Henry.1

    1Surgery/Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; 2Discovery Research, Immucor, Inc, Stamford, CT; 3Tissue Typing, The Ohio State University Wexner Medical Center, Columbus, OH; 4Methodist Hospital, Houston, TX; 5Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH.

    Recent interest in characterizing the complement-fixing ability of post-transplant donor specific alloantibodies (DSA) resulted in the enhancement of luminex solid phase alloantibody assays to determine…
  • 2016 American Transplant Congress

    Age-Based High GFR Associates with Clinical Risk Among Potential Living Donors, but Only with Increased Nephron Number Among Approved Donors.

    H. Chakkera,1 E. Poggio,3 A. Denic,2 J. Mathew,2 W. Kremers,2 J. Larson,2 H. Amer,2 F. Cosio,2 M. Stegall,2 S. Taler,2 A. Rule.2

    1Mayo Clinic, Arizona; 2Mayo Clinic, Rochester; 3Cleveland Clinic, OH.

    Background:Association of high GFR with clinical and kidney structural characteristics among living donors has not been studied.Methods: Study cohort:potential kidney donors evaluated at Mayo Clinic…
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