Articles tagged "Biopsy"

2016 American Transplant Congress
Management and Outcomes of Upper Extremity Deep Venous Thrombosis in Heart Transplant Patients.
A. Panakos,¹ D. Kramer,¹ M. McCarey,¹ P. Mather.²
¹Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA; ²Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA.
Upper extremity deep venous thrombosis (UEDVT) is common in post-heart transplant (OHT) patients, likely due to their multiple intravascular catheters and post-surgical state. The clinical…
2016 American Transplant Congress
Comparison of C4d Deposition in Renal Biopsies with Luminex-Based C3d Single Antigen Bead (SAB) Detection.
R. Pelletier,¹ I. Balazs,² P. Adams,³ P. Steller,³ N. DiPaola,⁴ L. Rankin,³ A. Diez,⁵ M. Henry.¹
¹Surgery/Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; ²Discovery Research, Immucor, Inc, Stamford, CT; ³Tissue Typing, The Ohio State University Wexner Medical Center, Columbus, OH; ⁴Methodist Hospital, Houston, TX; ⁵Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH.
Recent interest in characterizing the complement-fixing ability of post-transplant donor specific alloantibodies (DSA) resulted in the enhancement of luminex solid phase alloantibody assays to determine…
2016 American Transplant Congress
Age-Based High GFR Associates with Clinical Risk Among Potential Living Donors, but Only with Increased Nephron Number Among Approved Donors.
H. Chakkera,¹ E. Poggio,³ A. Denic,² J. Mathew,² W. Kremers,² J. Larson,² H. Amer,² F. Cosio,² M. Stegall,² S. Taler,² A. Rule.²
¹Mayo Clinic, Arizona; ²Mayo Clinic, Rochester; ³Cleveland Clinic, OH.
Background:Association of high GFR with clinical and kidney structural characteristics among living donors has not been studied.Methods: Study cohort:potential kidney donors evaluated at Mayo Clinic…
2016 American Transplant Congress
Glomerular Capillary C4d Staining without Evidence of Rejection Is Associated with Worse Graft Function in ABO-Incompatible Kidney Transplantation.
D. Toki,¹ M. Inui,¹ M. Okumi,² H. Ishida,² K. Setoguchi,¹ T. Shimizu,² K. Unagami,² K. Tanabe.²
¹Urology, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan; ²Urology, Tokyo Women's Medical University, Tokyo, Japan.
Objectives: C4d staining in the peritubular capillaries (C4d-PTC) is often observed without evidence of rejection in ABO-incompatible kidney transplantation (ABOI-KTx), and this phenomenon is generally…
2016 American Transplant Congress
Long-Term Death-Censored Graft Loss in the DeKAF Study.
A. Matas,¹ A. Fieberg,¹ R. Leduc,¹ F. Cosio,² R. Gaston,³ R. Mannon,³ M. Cecka,⁴ D. Rush,⁷ B. Kasiske,⁵ S. Gourishankar,⁶ J. Connett,¹ J. Grande.²
¹U of MN, Mpls, MN; ²Mayo, Rochester, MN; ³UAB, Birmingham, AB; ⁴UCLA, LA, CA; ⁵HCMC, Mpls, MN; ⁶U Alberta, Edmonton, AB, Canada; ⁷UMB, Winnipeg, MB, Canada.
The aim of the Deterioration of Kidney Allograft Function study (DeKAF) was to identify and assess the pathologies of troubled kidney grafts, that is, those…
2016 American Transplant Congress
Urinary Exosomal Annexin A1 Is a Predictive Biomarker of Post Kidney Transplant Complications.
H. Harada,¹ T. Murakami,² C. Yamamoto,² K. Hotta,¹ N. Fukuzawa,¹ M. Mitsuhashi.²
¹Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan; ²Hitachi Chemical Co. America, Ltd., Irvine, CA; ³Nanosomix, Inc., Aliso Viejo, CA.
IntroductionMonitoring of kidney allograft condition is important. We had exhibited non-invasive diagnostic modality of post-kidney transplant complications using urine exosomal and microvesicule (EMV) mRNA of…
2016 American Transplant Congress
Characterization of Vascular Lesions in Living Donor Renal Transplant Implant Biopsies.
F. Tinney Jr,¹ L. Yessayan,² M. Abouljoud,³ A. Patel.³
¹Wayne State University School of Medicine, Detroit, MI; ²Department of Nephrology, Henry Ford Hospital, Detroit, MI; ³Transplant Institute, Henry Ford Hospital, Detroit, MI.
INTRODUCTION: Nephrosclerosis is often associated with pathological injury to kidneys resulting from chronic high blood pressure and/or aging, and may predict the progression of decline…
2016 American Transplant Congress
A Molecular Biopsy Test for Probability of Non-Adherence.
P. Halloran,^1,3 G. Einecke,² J. Reeve.¹
¹ATAGC, Edmonton, AB, Canada; ²Hannover Medical School, Hannover, Germany; ³Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Afferent arteriolar hyalinosis (ah-score) in renal transplant biopsies increases with time of biopsy-post-transplant (TxBx), reflecting calcineurin inhibitor drug effects, donor aging, and progressive glomerular diseases.…
2016 American Transplant Congress
A Quantitative CD45 Immunohistochemical Assay Allows Precise and Reproducible Measurement of Inflammation in Renal Transplant Biopsies.
V. Walavalkar,¹ S. Bowman,¹ L. Laszik,¹ D. Ikle,² S. Chandran,¹ F. Vincenti,¹ Z. Laszik.¹
¹UCSF, San Francisco, CA; ²Rho, Chapel Hill, NC.
Purpose: Total inflammation (TI) is an important variable for the pathologic work-up of transplant kidney biopsies (TxBx) in the Banff schema. However, current standard pathologic…
2016 American Transplant Congress
Clinical Outcomes of Kidney Allograft Recipients with Apolipoprotein L1 (APOL1) Risk Alleles from Living Kidney Donors.
C. Dorr,^1,2,3 A. Hart,^1,2,3 D. Schladt,¹ A. Muthusamy,¹ R. Mannon,⁴ W. Oetting,² A. Matas,² P. Jacobson,² A. Israni.^1,2,3
¹Minneapolis Medical Research Foundation, Minneapolis; ²University of Minnesota, Minneapolis; ³Hennepin County Medical Center, Minneapolis; ⁴University of Alabama, Birmingham.
Background:Apolipoprotein L1 (APOL1) alleles G1 and G2 in deceased donors are associated with poor kidney allograft survival. However, the effect of these alleles in living…