Articles tagged "Biopsy"

2016 American Transplant Congress
De Novo Anti-HLA DSA Characteristics and Subclinical Antibody Mediated Kidney Allograft Injuries.
T. Yamamoto, Y. Watarai, A. Takeda, M. Okada, M. Tsujita, T. Hiramitsu, N. Goto, S. Narumi, K. Morozumi, K. Uchida, T. Kobayashi.
Nagoya daini red cross hospital, Nagoya, Japan.
Background It has been reported that de novo donor-specific HLA antibody (dn DSA) production is associated with chronic antibody-mediated rejection (CAMR) which leads to poor…
2016 American Transplant Congress
Biopsies for Delayed Graft Function After Alemtuzumab Induction in Kidney Transplantation: The Incidence of Early Rejection After Alemtuzumab Is Very Low but Not Negligible.
E. McGuire, C. Roufosse, T. Cook, D. Ashby, T. Cairns, J. Galliford, M. Willicombe, D. Taube, A. McLean.
Imperial Kidney & Transplant Centre, Hammersmith Hospital, Imperial College Healthcare, London, United Kingdom.
IntroductionUK practice advocates transplant biopsy (Bx) at day 7, then weekly in the presence of delayed graft function (DGF) because if missed, early rejection adversely…
2016 American Transplant Congress
Acute Rejection by Belatacept (Bela) Dosing Frequency: Results from a Phase II Study of Kidney Transplant Recipients.
F. Vincenti,¹ G. Blancho,² A. Durrbach,³ G. Grannas,⁴ J. Grinyó,⁵ U. Meier-Kriesche,⁶ M. Polinsky,⁶ H. Zhao,⁶ C. Larsen.⁷
¹UCSF, San Francisco, CA; ²University Hospital of Nantes, Nantes, France; ³University Hôpital of Bicêtre, Le Kremlin-Bicêtre, France; ⁴Medizinische Hochschule Hannover, Hannover, Germany; ⁵University Hospital of Bellvitge, Bellvitge, Spain; ⁶Bristol-Myers Squibb, Lawrenceville, NJ; ⁷Emory University Transplant Center, Atlanta, GA.
Background: At 1 year post transplant in IM103-100 (NCT00035555), bela-treated patients had similar acute rejection (AR) rates and significantly improved renal function vs cyclosporine A…
2016 American Transplant Congress
Randomized Controlled Study Evaluating Adherence Monitoring with Electronic Feedback on Reducing Renal Allograft Rejection.
A. Bodzin, Y. Becker, M. Josephson, P. Witkowski, M. Lockwood, L. Potter, B. Kane, L. Lourenco, J. Millis.
Transplant Center, University of Chicago, Chicago, IL.
Purpose: The negative impact of non-adherence to the immunosuppressant medication (IM) regimen on transplant outcomes is well recognized. In an attempt to improve outcomes, the…
2016 American Transplant Congress
A Novel Quantitative CD45 Immunofluorescence Assay Can Measure Inflammatory Load in Renal Transplant Biopsies with Excellent Reproducibility and Repeatability.
Z. Laszik,¹ D. Dobi,¹ L. Laszik,¹ D. Ikle,² S. Chandran,¹ F. Vincenti.¹
¹UCSF, San Francisco, CA; ²Rho, Chapel Hill, NC.
Purpose: The interobserver reproducibility of the current standard semiquantitative (Banff) grading of inflammation in renal transplant biopsies (TxBx) is suboptimal. We have recently developed a…
2016 American Transplant Congress
Unexpected Early Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients.
M. Yanik,¹ R. Mannon,² M. Seifert.¹
¹Pediatrics, University of Alabama at Birmingham, Birmingham, AL; ²Medicine, University of Alabama at Birmingham, Birmingham, AL.
Background: Calcineurin inhibitors effectively suppress the recipient immune response and facilitate early success in kidney transplantation. However, these drugs are potent nephrotoxins and contribute to…
2016 American Transplant Congress
DSA After Transplant Increases Risk of Renal Allograft Failure Independent of Concurrent Biopsy Results: The DEKAF Study Data.
J. Cecka,¹ J. Grande,² F. Cosio,² R. Leduc,³ The DeKAF Study Group.
¹UCLA Immunogenetics Center Department of Pathology, University of California-Los Angeles, Los Angeles, CA; ²Department of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; ³Department of Biostatistiscs, University of Minnesota School of Public Health, Minneapolis, MN.
Donor-specific HLA antibodies (DSA) are a major cause of renal allograft dysfunction and loss following transplant. The presence of DSA, with or without C4d deposition,…
2016 American Transplant Congress
Surveillance Biopsy Findings with Alemtuzumab (ALZ) Induction in Kidney Transplantation.
H. Madariaga,¹ R. Ugarte,¹ C. Drachenberg,² N. Costa,¹ B. Thomas,¹ J. Bromberg,³ M. Weir,¹ A. Haririan.¹
¹Department of Medicine, University of Maryland Medical Center, Baltimore, MD; ²Department of Pathology, University of Maryland Medical Center, Baltimore, MD; ³Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
The risk of subclinical histological changes in renal allografts with ALZ induction is not well defined. Hence, we performed a retrospective analysis of 527 surveillance…
2016 American Transplant Congress
Neutrophil-to-Lymphocyte Ratio as a Predictor of Polyomavirus BK Nephropathy in Kidney Transplant Patients.
K. Masutani,¹ A. Tsuchimoto,¹ Y. Matsukuma,¹ K. Kaku,² K. Kurihara,² Y. Okabe,² K. Tsuruya,¹ M. Nakamura,² T. Kitazono.¹
¹Department of Medicine and Clinical Science, Kyushu University, Fukuoka, Japan; ²Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan.
Background: Neutrophil-to-lymphocyte ratio (NLR) is an index for systemic inflammatory response, and has been reported to be a prognostic marker in the patients with malignancies…
2016 American Transplant Congress
Antibody Mediated Rejection and Mixed Acute Rejection: Long Term Results and Predictive Factors for Graft Loss Following Proteasome Inhibitor Therapy.
A. Lichvar,¹ A. Leino,¹ S. Tremblay,¹ B. Abu-Jawdeh,¹ A. Govil,¹ G. Mogilishetty,¹ M. Cardi,² J. Kremer,² M. Cuffy,^1,2 F. Paterno,¹ A. Shields,^1,2 D. Witte,¹ R. Alloway,¹ E. Woodle.¹
¹U of Cincinnati, Cincinnati; ²The Christ Hospital, Cincinnati.
Purpose: Proteasome inhibitor (PI) therapy has been increasingly used to treated antibody mediated rejection (AMR) and mixed acute rejection (MAR). The purpose of this study…