Articles tagged "Biopsy"

2017 American Transplant Congress
Characterization of De Novo Donor-Specific HLA Antibodies and Correlations with C4d+ Antibody-Mediated Rejection of Kidney Transplants.
R. Rajalingam,¹ D. Kopchaliiska,¹ O. Buenaventura,¹ M. Singh,² S. Tomlanovich.²
¹Immunogenetics and Transplantation Laboratory, Depart. of Surgery, University of California San Francisco, San Francisco, CA; ²Transplant Service, Department of Medicine, University of California San Francisc, San Francisco, CA
Aim: Characteristics of de novo donor-specific HLA antibodies (dnDSA) that are associated with C4d positive antibody-mediated rejection (C4d+ AMR) in kidney transplants have not been…
2017 American Transplant Congress
Use of Forensic DNA Testing to Trace Unethical Organ Procurement and Organ Trafficking Practices.
M. He,^1,2 A. Corson,² Z. Wang,³ J. Russo,² T. Trey.²
¹Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO; ²Doctors Against Forced Organ Harvesting, Washington DC; ³World Organization To Investigate The Persecution of Falun Gong, New York, NY
The purpose of this study is to establish a methodology, which allows to identify evidence of transplant organs originating from Falun Gong prisoners of conscience…
2017 American Transplant Congress
The Molecular Phenotypes of Rejection in Kidney Transplant Biopsies.
P. Halloran, J. Reeve, INTERCOMEX Study Group.
University of Alberta, Edmonton, AB, Canada
In a microarray analysis of 1208 kidney transplant indication biopsies, each biopsy was assigned molecular scores for seven phenotypes related to various aspects of TCMR,…
2017 American Transplant Congress
Biopsies (Bx) of Renal Allografts with Antibody- + Cell-Mediated Rejection (ABMR/CMR) Exhibit Gene Expression Signatures from Both Types of Rejection.
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² J. Mirocha,³ J. Kahwaji,¹ A. Vo,¹ S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles; ²Pathology, Cedars-Sinai Medical Center, Los Angeles; ³Biostatistics Center, Cedars-Sinai Medical Center, Los Angeles
Background: In HLA-sensitized kidney transplant patients (Pts) the concomitant presence of ABMR/CMR on Bx is associated with a more severe and (&) usually irreversible injury…
2016 American Transplant Congress
DSA After Transplant Increases Risk of Renal Allograft Failure Independent of Concurrent Biopsy Results: The DEKAF Study Data.
J. Cecka,¹ J. Grande,² F. Cosio,² R. Leduc,³ The DeKAF Study Group.
¹UCLA Immunogenetics Center Department of Pathology, University of California-Los Angeles, Los Angeles, CA; ²Department of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; ³Department of Biostatistiscs, University of Minnesota School of Public Health, Minneapolis, MN.
Donor-specific HLA antibodies (DSA) are a major cause of renal allograft dysfunction and loss following transplant. The presence of DSA, with or without C4d deposition,…
2016 American Transplant Congress
Surveillance Biopsy Findings with Alemtuzumab (ALZ) Induction in Kidney Transplantation.
H. Madariaga,¹ R. Ugarte,¹ C. Drachenberg,² N. Costa,¹ B. Thomas,¹ J. Bromberg,³ M. Weir,¹ A. Haririan.¹
¹Department of Medicine, University of Maryland Medical Center, Baltimore, MD; ²Department of Pathology, University of Maryland Medical Center, Baltimore, MD; ³Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
The risk of subclinical histological changes in renal allografts with ALZ induction is not well defined. Hence, we performed a retrospective analysis of 527 surveillance…
2016 American Transplant Congress
Neutrophil-to-Lymphocyte Ratio as a Predictor of Polyomavirus BK Nephropathy in Kidney Transplant Patients.
K. Masutani,¹ A. Tsuchimoto,¹ Y. Matsukuma,¹ K. Kaku,² K. Kurihara,² Y. Okabe,² K. Tsuruya,¹ M. Nakamura,² T. Kitazono.¹
¹Department of Medicine and Clinical Science, Kyushu University, Fukuoka, Japan; ²Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan.
Background: Neutrophil-to-lymphocyte ratio (NLR) is an index for systemic inflammatory response, and has been reported to be a prognostic marker in the patients with malignancies…
2016 American Transplant Congress
Antibody Mediated Rejection and Mixed Acute Rejection: Long Term Results and Predictive Factors for Graft Loss Following Proteasome Inhibitor Therapy.
A. Lichvar,¹ A. Leino,¹ S. Tremblay,¹ B. Abu-Jawdeh,¹ A. Govil,¹ G. Mogilishetty,¹ M. Cardi,² J. Kremer,² M. Cuffy,^1,2 F. Paterno,¹ A. Shields,^1,2 D. Witte,¹ R. Alloway,¹ E. Woodle.¹
¹U of Cincinnati, Cincinnati; ²The Christ Hospital, Cincinnati.
Purpose: Proteasome inhibitor (PI) therapy has been increasingly used to treated antibody mediated rejection (AMR) and mixed acute rejection (MAR). The purpose of this study…
2016 American Transplant Congress
Natural Language Processing Methods Allow Reliable Extraction of Banff Scores and Grades.
K. Reilly,¹ L. Lenert,¹ H. Anwar,² J. Thompson,¹ D. Taber,¹ P. Mauldin,¹ T. Srinivas.¹
¹MUSC, Charleston; ²IBM, NY.
Objective: National Data are sparse with regard to pathology of rejection. Incorporating biopsy pathology grades and lesion scores into analyses requires manual extraction and entry…
2016 American Transplant Congress
Real Time Assessment of Kidney Transplant Indication Biopsies by Microarrays: First Results of the INTERCOMEX Study.
P. Halloran,^1,2 J. Reeve,¹ INTERCOMEX Study Group.
¹University of Alberta, Edmonton, Canada; ²ATAGC, Edmonton, Canada.
Oncology uses central molecular tissue assessment (MTA) to guide management but the potential of this approach in transplantation is not known. We undertook a prospective…