2018 American Transplant Congress
Protocolar Biopsies in Patients with Subclinical De Novo DSA in Kidney Transplantation
De novo donor-specific antibody (DSA) is associated with antibody-mediated rejection (ABMR) and allograft loss. The aim of our study was to examine the histology associated…2018 American Transplant Congress
Graft Failure in Recurrent IgA Nephropathy Following Living Kidney Transplantation: Predictive Factors Analysis of 102 Biopsies
Aim To investigate the predictive factors related to graft failure in recurrentIgA nephropathy (IgAN) following living kidney transplantation. Methods We identified a series of 102…2018 American Transplant Congress
Highly Correlative Whole-Tissue Gene/protein Signatures to Score FFPE Transplant Biopsies with Inflammation and Acute Rejection
Unversity of California San Francisco, San Francisco.
Background: We have previously reported the quantification of a common immune response module (CRM) of 11 genes to identify and score acute rejection (AR) across…2018 American Transplant Congress
Outcomes of C4d+ Immunostaining in Heart Transplantation: Is All Immunologic AMR Bad?
Cedars Sinai Medical Center, Los Angeles, CA.
Purpose: Antibody-mediated rejection (AMR) remains a threat to patients (pts) following heart transplant (HTx). C4d immunostaining is one component involved in the diagnosis of AMR…2018 American Transplant Congress
Validation Study of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) and Cell-Mediated Rejection (CMR) in Renal Allograft Biopsies (Bx) Suggests Complexity of Molecular Diagnosis for ABMR Compared to CMR
Background: Various molecular signatures specific to ABMR and CMR based on gene expression in renal allograft Bx or peripheral blood mononuclear cells (PBMC) of renal…2018 American Transplant Congress
Age Difference between Donor and Recipient Predisposes to Early Interstitial Fibrosis and Tubular Atrophy in Pediatric Kidney Transplantation
Pediatric Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Introduction: Previous studies in adult kidney transplant recipients (KTRs) have shown that an increased age difference between donor and recipient increases the risk of arterial…2018 American Transplant Congress
Noninvasive Quantization of Intra-Renal Allograft C4d Deposition with Targeted Ultrasound Imaging
Antibody-mediated rejection (AMR) has emerged as the major cause of renal allograft dysfunction. C4d, a specific marker of AMR diagnosis, was strongly recommended for routine…2018 American Transplant Congress
Recombinant Relaxin Protects Liver Transplants from Ischemia-Reperfusion Damage via Hepatocyte Glucocorticoid Receptor: From Bench-to-Bedside
Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and acute/chronic rejection as well as a key obstacle to expanding the…2018 American Transplant Congress
Eluates from Fine-Needle Allograft Biopsy Increase Donor-Specific Antibody Identification in Antibody Mediated Rejection
1University of Cincinnati, Cincinnati; 2Hoxworth Blood Center, Cincinnati.
Aim. Antibody mediated rejection (AMR) represents a risk for graft loss, and the presence of circulating donor-specific antibody (cDSA) is a major criterion for AMR…2018 American Transplant Congress
Influence of 6 Months Protocol Biopsies with and without Intervention on Course of GFR after Pediatric Renal Transplantation
Data on protocol biopsies in childhood are rare. We evaluated renal function in 86 children after kidney transplantation (KTX) who underwent a protocol biopsy 6…
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