Articles tagged "Biopsy"

2019 American Transplant Congress
Outcomes and Clinical Utility of the kSORT Assay in the Prism Prospective Clinical Trial of Highly Sensitized Kidney Transplant Recipients
A. Schroeder, P. Towfighi, C. Hu, S. Hsieh, J. Liberto, I. Damm, T. Sigdel, P. Millar, M. Sarwal, F. Vincenti
Department of Surgery, UCSF, San Francisco, CA
*Purpose: kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of biopsy proven acute rejection (AR) and immune quiescence in kidney transplantation…
2019 American Transplant Congress
Subtyping Of Histologically Stable Kidney Transplants In Molecular Meta-analysis
D. Rychkov¹, T. Sigdel², J. Liberto², M. Sarwal², M. Sirota³
¹ICHS, Department of Surgery, UCSF, San Francisco, CA, ²Department of Surgery, UCSF, San Francisco, CA, ³ICHS, UCSF, San Francisco, CA
*Purpose: Histologically stable allografts have been shown to have molecular inflammation by prior gene expression studies. Nevertheless, there are no methodologies in place to sub-group…
2019 American Transplant Congress
Racial Differences in Acute Kidney Injury Occurrence among Deceased Kidney Donors
M. Doshi¹, I. Hall², S. Mohan³, C. Liu⁴, H. Philbrook⁴, P. Reese⁵, S. Mansour⁶, F. Weng⁷, E. Akalin⁸, J. Bromberg⁹, M. Harhay¹⁰, T. Muthukumar¹¹, B. Schroeppel¹², P. Singh¹³, C. Parikh⁴
¹University of Michigan, Ann Arbor, MI, ²University of Utah, Salt Lake City, UT, ³Columbia, New York, NY, ⁴Johns Hopkins, Baltimore, MD, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Yale University, New Haven, CT, ⁷St. Barnabas, Livingston, NJ, ⁸Mount Sinai, New York, NY, ⁹University of Maryland, Baltimore, MD, ¹⁰Drexel, Philadelphia, PA, ¹¹Cornell, New York, NY, ¹²University of Ulm, Ulm, Germany, ¹³Jefferson, Philadelphia, PA
*Purpose: Kidneys from African American (AA) deceased donors have lower graft survival than kidneys from white donors, regardless of recipient race. We hypothesized that kidneys…
2019 American Transplant Congress
Impact of T-cell Mediated Allograft Inflammation within First-Year after Kidney Transplantation: An Analysis of Paired Biopsies from a Single Center Study
S. Tandukar, R. Mehta, I. Owoyemi, D. Jorgensen, P. Sood, S. Hariharan
Division of Transplant Nephrology, Thomas E. Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: We evaluated the impact of Clinical and Sub-Clinical T-Cell-Mediated Rejection (TCMR) and Sub-Clinical Inflammation (SCI) within 1 year post-transplant.*Methods: Adult kidney transplant patients who…
2019 American Transplant Congress
Early Allograft Dysfunction in the Setting of Histologic Ischemia Reperfusion Injury Following Liver Transplantation: Analysis of Predictors and Outcomes
T. Ito, J. Aziz, V. G. Agopian, S. Younan, J. DiNorcia, H. Yersiz, D. G. Farmer, R. W. Busuttil, F. M. Kaldas
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Hepatic ischemia-reperfusion injury (IRI) in Liver Transplantation (LT) is believed to contribute to Early Allograft Dysfunction (EAD). However, the relationship between IRI and EAD…
2019 American Transplant Congress
Hepatocyte SIRT1 Modulates ATF4/CHOP and Mitigates Liver Transplant Ischemia-Reperfusion Injury: From Bench-to-Bedside
H. Hirao¹, S. Kageyama¹, K. Kadono¹, K. Nakamura¹, T. Ito¹, K. J. Dery¹, D. Oncel¹, X. Li², B. Ke¹, F. M. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec‐Weglinski¹
¹Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA, ²National Institute of Environmental Health Sciences, Research Triangle Park, NC
*Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation against hepatic ischemia-reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Although…
2019 American Transplant Congress
Role of Procurement and Reperfusion Biopsy in Kidney Transplant in Evaluating and Predicting Outcomes of Deceased Donor Kidneys
S. Faiz, A. Pai, A. De Golovine, A. Edwards, W. Glass, A. Tchakarov
UT Houston, Houston, TX
*Purpose: Pathologic assessment of donor organs by use of procurement biopsies (PB) provides information regarding organ quality. Most commonly cited reason for organ discard is…
2019 American Transplant Congress
Urinary Biomarkers- CXCL9 and CXCL10 for Non-Invasive, Early Diagnosis of Rejection in Pediatric Renal Transplantation
R. P. George¹, B. Hanberry², I. Dave², B. Lee², R. Garro¹, C. McCracken², B. Warshaw¹
¹Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, ²Pediatrics, Emory University, Atlanta, GA
*Purpose: Renal transplantation is the treatment of choice for End Stage Renal Disease, but requires strict medication adherence and lifelong surveillance for rejection, infection and…
2019 American Transplant Congress
Evaluation of Pretransplant Biopsy as a Influence Factor of Early Graft Function after Donated Kidney Transplantation
X. Qiuxiang, W. Zhendi
Urology Surgery, Wuhan Union Hospital, Wuhan, China
*Purpose: To investigate the relationship between pretransplant biopsy and the early graft function after donated kidney transplantation.*Methods: We examined pretransplant biopsies for 240 kidney transplant…
2019 American Transplant Congress
The Crucial Role of Molecular Microscope in the Interpretation of Ambiguous Lesions Such as Banff Borderline Changes and Tubulo-Interstitial Inflammation Accompanying PVAN
D. Deborska-Materkowska¹, A. Perkowska-Ptasinska¹, M. Ciszek¹, P. F. Halloran², M. Myslak³
¹Warsaw Medical University, Warsaw, Poland, ²ATAGC, University of Alberta, Edmonton AB, AB, Canada, ³Pomeranian Medical University, Szczecin, Poland
*Purpose: Anti-rejection treatment implementation is highly dependent on morphologic lesions interpretation based on Banff classification. Unfortunately, some light microscopic phenotypes are ambiguous which constricts the…