Articles tagged "Biopsy"

2020 American Transplant Congress
Calcium Oxalate Deposition in Kidney Allografts: Clinical Chracteristics and Outcome
S. Sritharan¹, J. Kamal², S. A. Husain¹, I. Batal¹, J. Chang¹
¹Columbia University Irving Medical Center, New York, NY, ²University of Virginia, Charlottesville, VA
*Purpose: To better understand its clinical significance and prognostic value, we investigated the clinical characteristics and outcomes of patients with calcium oxalate deposition in kidney…
2020 American Transplant Congress
The Role of the Molecular Microscope to Guide Therapy for T-Cell Mediated Rejection in Kidney Transplants
D. Kumar¹, M. Demehin¹, J. Christensen¹, L. Kamal¹, I. Moinuddin¹, M. Levy¹, C. Bhati¹, A. King¹, H. D. Massey¹, P. Halloran², G. Gupta¹
¹Virginia Commonwealth University, Glen Allen, VA, ²ATAGC, Edmonton, AB, Canada
*Purpose: Histologic lesions (I+T) to characterize T-cell mediated rejection (TCMR) can be non-specific. In some cases the inflammation may represent a ‘response to wounding’ rather…
2020 American Transplant Congress
Impact of Severity of Glomerulosclerosis on Long-Term Outcomes in Deceased Donor Renal Transplant Recipients with Donor Acute Kidney Injury
A. Brar¹, A. Gruessner², D. Adey¹, M. Salifu²
¹University of California, San Francisco, San Francisco, CA, ²SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: With long waitlist times for renal transplantation,there is a need to reduce discard rates of donor kidneys.The purpose of this study is to assess…
2020 American Transplant Congress
Calcium Phosphate Crystals: An Under Recognized Cause of Kidney Allograft Injury?
R. H. Naik, E. Ramos, B. Paueksakon, M. Anand, A. Fogo, B. P. Concepcion, M. Lusco
Vanderbilt University Medical Center, Nashville, TN
*Purpose: Calcium phosphate (CaPhos) crystals are a known cause of dysfunction in native kidneys. Our objectives were to describe the incidence of CaPhos crystal deposition…
2020 American Transplant Congress
Use of tCRM to Aid Diagnosis of Allograft Rejection in Kidney Transplantation
A. Zarinsefat¹, J. Liberto¹, I. Damm¹, C. Ramirez², J. Guerra², J. Alberu², M. Sarwal¹
¹University of California San Francisco, San Francisco, CA, ²Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico
*Purpose: To apply an unbiased, quantitative, molecular profiling score for graft inflammation using standardized assays, in the context of a prospective clinical trial in kidney…
2020 American Transplant Congress
Impact of Chronic Changes on Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation (DDKTx)
J. Ninan, R. Heilman, M. Smith, J. Harbell, S. S. Nair, C. Jadloweic, H. Khamash, A. Moss, K. S. Reddy
Mayo Clinic, Phoenix, AZ
*Purpose: The value of PBx is unclear. The aim of this study was to determine the prognostic value of chronic changes on PBx on graft…
2020 American Transplant Congress
Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies
I. Moinuddin¹, D. Kumar¹, L. Kamal¹, A. King¹, L. Kang¹, M. Levy¹, S. Bobba¹, D. Massey¹, P. Halloran², G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…
2020 American Transplant Congress
Glomerulitis in One-Hour Biopsy after ABO-Blood Type Incompatible Kidney Transplantation Sensitively Suggests Occurrence of Antibody-Mediated Rejection
D. Iwami, K. Hotta, N. Iwahara, N. Shinohara
Renal and Genitourinary Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
*Purpose: Antibody-mediated rejection (ABMR) after ABO-blood type-incompatible kidney transplantation (ABOi-KTx) can affect transplant outcome even lead to allograft loss unless promptly diagnosed and adequately treated.…
2020 American Transplant Congress
Yield and Utility of Surveillance Kidney Biopsies in Pediatric Kidney Transplant Recipients at Various Time Points Post-Transplant
A. Landsberg¹, M. Riazy², T. Blydt-Hansen¹
¹Nephrology, BC Children's Hospital, Vancouver, BC, Canada, ²Pathology and Laboratory Medicine, St. Paul's Hospital, Vancouver, BC, Canada
*Purpose: There lacks consensus regarding the appropriate timing of routine surveillance biopsies (SB) for pediatric kidney transplant recipients. We evaluated the yield of positive biopsy…
2020 American Transplant Congress
Avoiding Surveillance Biopsy: How? When? Now!
A. Ang¹, C. Schieve², S. Rose², C. Kew¹, M. R. First², R. B. Mannon¹
¹School of Medicine, University of Alabama, Birmingham, Birmingham, AL, ²Transplant Genomics Inc., Mansfield, MA
*Purpose: The TruGraf™ blood test measures a specific gene expression signature in the peripheral blood mononuclear cells to enable noninvasive serial assessment of kidney transplant…