Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
*Purpose: To investigate the effect of JC virus (JCV) on the development and prognosis of BK virus (BKV) infection and polyomavirus nephropathy (PVN) in renal transplant recipients.
*Methods: A total of 196 renal transplant recipients who underwent graft biopsy in our hospital from May 2017 to December 2018 were divided into PVN group (n = 69) and non-PVN group (n = 127). The differences of infection rate and replication level of JCV and BKV between the two groups were compared, while the effects of JCV on the pathological degree of PVN and the relationship between JCV and graft survival rate and function of PVN recipients were investigated.
*Results: In PVN and non-PVN groups, 69 cases (100%) and 35 cases (27.6%) were infected with BKV (P<0.001), 22 cases (31.9%) and 48 cases (37.8%) were infected with JCV (P=0.409), respectively. In PVN and non-PVN groups, the median level of BKV-DNA in plasma was 4.06×104 and 2.49×103(P=0.014), that in urine was 1.4×109 and 2.64×106 (P<0.001), respectively; meanwhile, the median level of JCV-DNA in urine was 1.3×108 and 2.87×106 (P=0.065), that in plasma was 2.43×104 and 0 (P=0.016), respectively. In the PVN group, there was no significant correlation between JCV level and the scores of main pathological parameters (t, ct, i, ci and SV40-T extent) (all P>0.05). While there is a positive linear correlation between JCV and BKV level (r=0.478, p=0.025). The creatinine level in PVN recipients with JCV viremia one year after biopsy was significantly higher than that of non-JCV viremia recipients (P=0.041).
*Conclusions: JCV plays a positive role in promoting BKV replication among PVN recipients. It is recommended to monitor plasma JCV-DNA in recipients with PVN.
|BKV-DNA in urine, median copies/ml||1.4×109(4.6×105~1.0×1011)||2.64×106(6.56×102~3.8×1010)||<0.001|
|BKV-DNA in plasma, median copies/ml||4.06×104(5.0×102~1.61×106)||2.49×103(2.05×102~4.08×105)||0.014|
|JCV-DNA in urine, median copies/ml||1.3×108(1.64×103~2.06×109)||2.87×106(1.51×103~2.31×1010)||0.065|
|JCV-DNA in plasma, median copies/ml||2.43×104(1.23×103~3.06×105)||0(0)||0.016|
|BKV Viruria, n (%)||69(100%)||35(27.6%)||<0.001|
|BKV Viremia, n (%)||43(62.3%)||7(5.5%)||<0.001|
|JCV Viremia, n (%)||8(11.6%)||0(0%)||<0.001|
To cite this abstract in AMA style:Huang G, Huang Y, Chen X, Qiu J, Li J, Wang C, Chen L. Effect of JC Virus on Polyomavirus Nephropathy in Renal Transplant Recipients [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/effect-of-jc-virus-on-polyomavirus-nephropathy-in-renal-transplant-recipients/. Accessed October 29, 2020.
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