Articles tagged "Bioengineering"

2020 American Transplant Congress
A Novel Injectable Hydrogel-Based Approach to Localize and Tune the Actuation of Enhanced Costimulation Blockade to the Strength of Transplant Rejection
A. Komin¹, C. Liang², P. Majumder², X. Calderon-Colon³, O. Tiburzi³, M. Iglesias Lozano¹, Y. Zhang¹, G. Brandacher¹, J. Patrone³, J. Schneider², G. Raimondi¹
¹Johns Hopkins School of Medicine, Baltimore, MD, ²NIH National Cancer Institute, Frederick, MD, ³JHU Applied Physics Laboratory, Laurel, MD
*Purpose: Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are needed. The clinical efficacy of CTLA4-Ig…
2020 American Transplant Congress
Multimodal Theranostic Nanocolloid Platform for Imaging, Targeted Drug Delivery and Organ Preservation in Transplantation
J. M. Janjic¹, E. Lambert¹, L. Liu¹, M. Herneisey¹, V. S. Gorantla²
¹School of Pharmacy, Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, ²Wake Forest Institute for Regenerative Medicine, Winston- Salem, NC
*Purpose: The goal of this project design and development of multifunctional nanomedicines to address unique and complex therapeutic outcomes in transplantation and organ preservation. Presented…
2020 American Transplant Congress
Development and Cell Surface Testing of a Novel Nanofiber Technology for Targeted Delivery of Therapeutic Regulatory T Cells
J. M. Mathew¹, S. Lee², Y. Sambandam¹, L. A. Fraser², T. D. Clemons², A. Kolberg², J. He¹, L. C. Palmer², M. T. McClendon², Z. J. Zhang¹, J. R. Leventhal¹, S. I. Stupp², L. Gallon¹
¹Surgery -Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models, and to be increased in their numbers in tolerant human…
2020 American Transplant Congress
Building Kidneys from Stem Cells for Transplantation
I. M. Rogers¹, J. Whiteley², T. Chow², T. Bongolan², L. Mazilescu³, P. Urbanellis³, S. Ganesh³, M. Selzner³
¹Physiology, University of Toronto, Toronto, ON, Canada, ²LTRI-Sinai Health System, Toronto, ON, Canada, ³MOTU, University Health Network, Toronto, ON, Canada
*Purpose: Our vision is to build a human kidney by combining human stem cells with porcine kidney extracellular matrix.*Methods: Kidneys were decellularized followed by repopulation…
2020 American Transplant Congress
Prolonged Functional Human 3D Liver Organoids as an In Vitro Liver Disease Model
W. Zhang¹, A. Isidan¹, A. M. Chen¹, L. J. Smith², H. L. Francis³, G. Alpini³, E. Gramelspacher¹, P. Li¹, B. Ekser¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²3D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, ³Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
*Purpose: Animal models used for evaluating the mechanisms of liver disease do not fully mimic the complex architecture and metabolic functions of the human liver.…
2020 American Transplant Congress
Formation Of Artificial Blood Vessels Using ECM In 3D Bioprinting
P. Cywoniuk, T. Bryniarski, T. Dobrzanski, K. Kosowska, M. Klak, G. Tymicki, P. Kowalska, M. Gomolka, P. Turowski, I. Zamora, A. Berman, M. Wszola
Foundation of Research and Science Development, Warsaw, Poland
*Purpose: Development of fully functional blood vessels in expanding field of artificial tissues and organs for transplantations in regenerative medicine is fundamental to provide proper…
2020 American Transplant Congress
Characterization of a Clinically Scaled Bioengineered Liver Seeded with Primary Hepatocytes and Endothelial Cells
D. S. Davidow¹, J. J. Ross¹, B. D. Anderson¹, A. Stumbras¹, A. A. Katane¹, R. Lindeman¹, B. G. Steiner¹, A. Mendenhall¹, K. Gahlbeck¹, S. Armstrong¹, B. P. Amiot², E. D. Nelson², T. Gilbert¹, S. L. Nyberg²
¹Miromatrix, Eden Prairie, MN, ²Mayo Clinic, Rochester, MN
*Purpose: Advancements in whole organ bioengineering have the potential to offer solutions to a chronically insufficient donor organ supply. We recently demonstrated an ability to…
2020 American Transplant Congress
Production of Detergent-Free ECM-Derived Bioinks for Bioprinting of Bionic Pancreas Ready for Clinical Use
M. Wszola¹, M. Klak¹, G. Tymicki¹, A. Berman¹, K. Kosowska¹, T. Bryniarski¹, P. Cywoniuk¹, M. Gomolka¹, P. Kowalska¹, P. Turowski¹, A. Kaminski²
¹Foundation for Research and Science Development, Warsaw, Poland, ²Medical University of Warsaw, Warsaw, Poland
*Purpose: Bioprinting is the process of creating 3D tissue analogues. For this purpose, it is necessary to produce a special bioink that will be able…
2020 American Transplant Congress
Biointegration and Function of 3D Printed Bionic Pancreatic Petals on a Mouse Model
M. Wszola¹, M. Klak¹, G. Tymicki¹, A. Berman¹, K. Kosowska¹, T. Bryniarski¹, P. Cywoniuk¹, M. Gomolka¹, P. Kowalska¹, P. Turowski¹, A. Kaminski²
¹Foundation for Research and Science Development, Warsaw, Poland, ²Medical University of Warsaw, Warsaw, Poland
*Purpose: Despite the technologically advanced integrated systems of continuous glycemic control and insulin supply, it is still impossible to obtain results of diabetes treatment in…
2019 American Transplant Congress
Hepatic Stellate Cells and Liver Derived Endothelial Cells Improve Scaffold-Free 3D-Bioprintied Liver Model
A. M. Chen¹, W. Zhang¹, C. J. Koehler¹, K. Saglam¹, A. Isidan¹, J. R. Walsh¹, R. A. Naqvi¹, E. Gramelspacher¹, L. J. Smith², P. Li¹, B. Ekser¹
¹Transplant Division, Department of Surgery, Indiana University, Indianapolis, IN, ²3D-Bioprinting Core, Indiana University School of Medicine, Indianapolis, IN
*Purpose: Hepatic stellate cells (HSC) comprise about 2-8% of liver cells and are vital to hepatocellular function. Scaffold-free 3D-bioprinting (SF3DBP) allows creation of realistic tissue…