Articles tagged "Bioengineering"

2020 American Transplant Congress
Characterization of a Clinically Scaled Bioengineered Liver Seeded with Primary Hepatocytes and Endothelial Cells
D. S. Davidow¹, J. J. Ross¹, B. D. Anderson¹, A. Stumbras¹, A. A. Katane¹, R. Lindeman¹, B. G. Steiner¹, A. Mendenhall¹, K. Gahlbeck¹, S. Armstrong¹, B. P. Amiot², E. D. Nelson², T. Gilbert¹, S. L. Nyberg²
¹Miromatrix, Eden Prairie, MN, ²Mayo Clinic, Rochester, MN
*Purpose: Advancements in whole organ bioengineering have the potential to offer solutions to a chronically insufficient donor organ supply. We recently demonstrated an ability to…
2020 American Transplant Congress
Production of Detergent-Free ECM-Derived Bioinks for Bioprinting of Bionic Pancreas Ready for Clinical Use
M. Wszola¹, M. Klak¹, G. Tymicki¹, A. Berman¹, K. Kosowska¹, T. Bryniarski¹, P. Cywoniuk¹, M. Gomolka¹, P. Kowalska¹, P. Turowski¹, A. Kaminski²
¹Foundation for Research and Science Development, Warsaw, Poland, ²Medical University of Warsaw, Warsaw, Poland
*Purpose: Bioprinting is the process of creating 3D tissue analogues. For this purpose, it is necessary to produce a special bioink that will be able…
2020 American Transplant Congress
Biointegration and Function of 3D Printed Bionic Pancreatic Petals on a Mouse Model
M. Wszola¹, M. Klak¹, G. Tymicki¹, A. Berman¹, K. Kosowska¹, T. Bryniarski¹, P. Cywoniuk¹, M. Gomolka¹, P. Kowalska¹, P. Turowski¹, A. Kaminski²
¹Foundation for Research and Science Development, Warsaw, Poland, ²Medical University of Warsaw, Warsaw, Poland
*Purpose: Despite the technologically advanced integrated systems of continuous glycemic control and insulin supply, it is still impossible to obtain results of diabetes treatment in…
2020 American Transplant Congress
Recruitment of Regulatory T Cells Promotes Donor-Specific Tolerance in Vascularized Composite Allotransplantation
J. D. Fisher¹, W. Zhang², S. C. Balmert³, A. M. Aral¹, Y. Kulahci⁴, A. P. Acharya⁴, J. Li², H. R. Turnquist⁵, A. W. Thomson⁵, M. G. Solari², V. S. Gorantla⁶, S. R. Little⁴
¹Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, ²Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, ³Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, ⁵Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, ⁶Department of Bioengineering, Wake Forest University, Winston-Salem, NC
*Purpose: Vascularized composite allotransplantation (VCA) encompasses face and limb transplantation, but as with organ transplantation, it requires lifelong regimens of immunosuppressive drugs to prevent rejection.*Methods:…
2020 American Transplant Congress
Concept Discussion: Five Experimental Stages to Establish the Methodologies for Organ Farming
R. F. Smith
George Washington University, Bristow, VA
*Purpose: Most of the technologies to grow human organs in vitro already exist, but experimentation (and policy development support) will be required to ensure that:*Methods:…
2020 American Transplant Congress
New Strategy to Maximize Nanomedicine Delivery During Ex Vivo Organ Perfusion
C. Albert¹, L. Bracaglia¹, A. Koide², C. M. Edwards³, T. Lysyy³, J. S. Pober⁴, M. Saltzman¹, S. Koide², G. Tietjen³
¹Biomedical Engineering, Yale University, New Haven, CT, ²Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, ³Surgery, Yale University, New Haven, CT, ⁴Immunobiology, Yale University, New Haven, CT
*Purpose: Organ transplant is a highly successful therapy for patients facing end stage organ failure. However, there is a severe lack of transplantable organs which…
2020 American Transplant Congress
3D Bioprinted Intrahepatic Cholangiocarcinoma Model and 7-Day Perfusion with Gemcitabine and Cisplatin: Modeling the Tumor Microenvironment and Response to Chemotherapy
A. M. Chen¹, W. Zhang¹, J. Sterner², L. Kennedy³, A. Isidan¹, E. Gramelspacher¹, H. L. Francis³, G. Alpini³, L. J. Smith², P. Li¹, B. Ekser¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²3D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, ³Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
*Purpose: Over 8,000 patients are newly diagnosed with cholangiocarcinoma (CCA) in the United States each year.Understanding the CCA microenvironment will facilitate the development of novel…
2020 American Transplant Congress
Regulatory T Cells Engineered with TCR-Signaling-Responsive Il-2 Nanogels Suppress Alloimmunity in Sites of Antigen Encounter
S. K. Eskandari¹, J. B. Alhaddad¹, I. Sulkaj², M. B. Melo², N. Li², H. Allos¹, B. Kollar¹, M. A. Seelen³, D. J. Irvine⁴, J. Azzi¹
¹Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Koch Institute for Integrative Cancer Research, Massachusetts Insitute of Technology, Cambridge, MA, ³Nephrology, University Medical Center Groningen, Groningen, Netherlands, ⁴Medicine, Koch Institute for Integrative Cancer Research, Massachusetts Insitute of Technology, Cambridge, MA
*Purpose:
2020 American Transplant Congress
Tonic-Signaling Chimeric Antigen Receptors Drive Exhaustion in Regulatory T Cells
C. Lamarche¹, C. Mackall², E. Weber³, M. Levings⁴
¹University of British Columbia, Vancouver, BC, Canada, ²Stanford University School of Medicine, Standford, CA, ³Stanford University School of Medicine, Stanford, CA, ⁴Surgery, University of British Columbia and BC Children's Hospital Research Institute, Vancouver, BC, Canada
*Purpose: Regulatory T cells (Tregs) and chimeric antigen receptor (CAR) Tregs are a promising cell therapy to prevent or treat autoimmune diseases or allograft rejection.…
2019 American Transplant Congress
Preservation of Pancreatic Islets with Stem Cell Derived CD34+ Vascular Endothelial Progenitor Cells
C. Ward¹, L. Vo², E. De Klerk², G. Faleo², Y. Kelly¹, J. Bluestone², M. Hebrok², P. Stock¹, Q. Tang¹
¹Surgery, UCSF, San Francisco, CA, ²Diabetes Center, UCSF, San Francisco, CA
*Purpose: Islet transplantation can cure Type 1 diabetes; however, multiple donors are needed due to extensive perioperative loss of islets when removed from their native…