2018 American Transplant Congress
Activity Nanosensors for Early and Noninvasive Detection of Acute Organ Transplant Rejection
Purpose: We engineered activity nanosensors that sense anti-allograft T cell activity in vivo to noninvasively detect the onset of acute cellular rejection from urine.Methods: Granzyme…2018 American Transplant Congress
Engineering Regulatory T Cells with Interleukin (IL-)2 Nanogel for Improved Alloimmune Suppression
Clinical trials of adoptively transferred regulatory T cells (TRegs) have been hindered by the short lifespan of these transferred TRegs. Systemic injection of low-dose interleukin…2018 American Transplant Congress
Sensing T Cell Killing Activity with Granzyme B Activity Probes
Purpose: We developed activity-based probes that sense Granzyme B (GzmB) activity during alloreactive T cell killing of donor cellsMethods: FITC-labelled GzmB substrate (IEFDSG) was synthesized…2018 American Transplant Congress
Biomaterial-Based Localized and Controlled Delivery of Tofacitinib to Actuate Enhanced Costimulation Blockade and Promote Long-Term Transplant Survival
Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are highly needed. We investigated two innovative drug…2018 American Transplant Congress
Pancreas Decellularization Protocol – Comparison of Methods
Foundation of Research and Science Development, Otwock, Poland.
Background: Whole organ decellularization is gaining a lot of popularity since its development in tissue engineering. It is a process which allows to create complex…2018 American Transplant Congress
Re-Endothelialization of Liver Xenografts Utilizing Human Endothelial Cells
1Surgery, University of Maryland, Baltimore, MD; 2Pathology, University of Maryland, Baltimore, MD.
Introduction:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Xenograft vascular endothelium represents the initial site…2018 American Transplant Congress
Successful Patency in Blood Conduits for an Artificial Kidney Membrane with Biocompatible Coatings
1VUMC, Nashville; 2UCSF, San Francisco.
BACKGROUND: An implantable artificial kidney may address the growing organ shortage and improve outcomes and quality of life for those with end stage renal disease.…2018 American Transplant Congress
Liver Preservation with Machine Perfusion and a New Human-Derived Hemoglobin-Based Oxygen Carrier Solution (HDHBOC)
1VirTech Bio, Inc, Natick, MA; 2University of Pittsburgh, Pittsburgh, PA.
Introduction: Machine perfusion (MP) is becoming the new standard for liver preservation following the successful implementation of devices for kidney and lung preservation ex-vivo. Liver…2017 American Transplant Congress
Decellularized Rat Liver Scaffolds Support Survival and Metabolic Function of Multilineage Allogenic Cells.
University of Maryland School of Medcine, Baltimore, MD
Background:Organ bioengineering has the potential to completely eliminate the donor organ shortage. Here, we examine the feasibility of a decellularized liver construct to support the…2017 American Transplant Congress
Technically Successful Miniaturization of Blood Hemofilters for an Artificial Kidney via Bioengineering Techniques.
Background: Creating flow channel pathways for an implantable artificial kidney with minimal risk of thrombosis is particularly difficult when miniaturizing into a multilayer bio-hybrid device.…
American Transplant Congress abstracts