Articles tagged "Bioengineering"

2021 American Transplant Congress
Cross-Circulation for Extracorporeal Liver Support in a Swine Model
W. K. Wu¹, A. Tumen¹, J. W. Stokes², R. Ukita², A. E. Hozain³, C. R. Flynn², M. J. Lee³, J. R. Talackine², N. L. Cardwell², J. A. Reimer³, M. Pinezich³, C. Benson², G. Vunjak-Novakovic³, S. P. Alexopoulos², M. Bacchetta²
¹co-first authors, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN, ³Columbia University Medical Center, New York, NY
*Purpose: Although machine perfusion has gained momentum as an organ preservation strategy in liver transplantation, significant organ shortages and waitlist mortality persist, highlighting unmet needs…
2021 American Transplant Congress
Islet Allotransplantation Into Pre-vascularized Sernova Cell Pouch^TM – Preliminary Results from the University of Chicago
P. J. Bachul¹, P. E. Borek¹, G. S. Generette¹, A. Perez-Gutierrez¹, K. Jayant¹, K. Golab¹, L. Basto¹, L. Perea¹, M. Tibudan¹, C. Thomas², L. Philipson², J. Fung¹, P. Witkowski¹
¹Surgery, University of Chicago, Chicago, IL, ²Medicine, University of Chicago, Chicago, IL
*Purpose: Previous first-in-human pilot study showed safety but the conditions did not allow for detectable islet function post-transplantation into the pre-vascularized Sernova Cell Pouches (SCPs)…
2021 American Transplant Congress
Development of a Lateral Flow Assay Detecting CXCL9 within Antibody Mediated and Acute T Cell Mediated Rejections After Kidney Transplantation
L. K. Seiler¹, R. Jonczyk¹, P. Lindner¹, L. Phung¹, C. Falk², C. Blume¹
¹Faculty of Natural Sciences, Institute of Technical Chemistry, Hannover, Germany, ²Institute of Transplant Immunology, Medical School Hannover, Hannover, Germany
*Purpose: Despite tremendous improvements in quality and tolerability of immunosuppressive medications after successful kidney transplantation, numerous kidney grafts undergo acute and chronic rejections with following…
2021 American Transplant Congress
Enhancement of Regulatory T Cell Therapies by Biomimetic Nanofiber Matrices on Single Cells
L. A. Fraser¹, S. Lee¹, Y. Sambandam², J. He², X. Huang², D. Z. Ivancic², J. Mathew², Z. J. Zhang², J. R. Leventhal², L. Gallon², S. I. Stupp¹
¹Simpson Querrey Institute, Northwestern, Chicago, IL, ²Surgery – Comprehensive Transplant Center, Northwestern, Chicago, IL
*Purpose: Here we report a new method to create an artificial and biodegradable matrix of biomimetic nanofibers on single cells with the goal of enhancing…
2020 American Transplant Congress
Prolonged In Vivo Perfusion of a Re-Endothelialized Human-Scale Tissue Engineered Kidney Graft
J. S. Uzarski¹, E. E. Russell¹, E. C. Beck¹, M. Holzner², V. Wadhera², D. Adamson², T. Gilbert¹, S. Florman², D. S. Davidow¹, R. Shapiro², J. Ross¹
¹Research & Development, Miromatrix Medical Inc., Eden Prairie, MN, ²Recanati/Miller Institute, Mount Sinai, New York, NY
*Purpose: Advances are desperately needed to increase the supply of transplantable kidneys for the 100,000 patients on the waiting list. Whole organ engineering is one…
2020 American Transplant Congress
Real-Time Viability Assessment During Normothermic Machine Perfusion with Resonance Raman Spectroscopy
R. J. De Vries¹, S. Raigani¹, P. Romfh², S. E. Cronin¹, C. A. Pendexter¹, C. Carroll¹, T. M. Van Gulik³, P. Chen², K. Uygun¹, H. Yeh¹, S. N. Tessier¹
¹Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Pendar Technologies, Cambridge, MA, ³Surgery, Amsterdam University Medidical Centers, Location AMC, Amsterdam, Netherlands
*Purpose: Viability assessment during normothermic machine perfusion (NMP) continues to lack objective metrics that facilitate accurate clinical decision making, in order to minimize discard rates…
2020 American Transplant Congress
The Impact of Transportation Innovation for Human Organs: Surgical Perspectives and Implications
T. Talaie, S. Niederhaus, E. Villalonga, J. Bromberg, J. Scalea
Transplant Surgery, Unviersity of Maryland Medical Center, Baltimore, MD
*Purpose: Recent changes in allocation and the ongoing organ donor shortage have led to increased regional and national sharing, putting intense pressure on the organ…
2020 American Transplant Congress
A Novel Injectable Hydrogel-Based Approach to Localize and Tune the Actuation of Enhanced Costimulation Blockade to the Strength of Transplant Rejection
A. Komin¹, C. Liang², P. Majumder², X. Calderon-Colon³, O. Tiburzi³, M. Iglesias Lozano¹, Y. Zhang¹, G. Brandacher¹, J. Patrone³, J. Schneider², G. Raimondi¹
¹Johns Hopkins School of Medicine, Baltimore, MD, ²NIH National Cancer Institute, Frederick, MD, ³JHU Applied Physics Laboratory, Laurel, MD
*Purpose: Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are needed. The clinical efficacy of CTLA4-Ig…
2020 American Transplant Congress
Multimodal Theranostic Nanocolloid Platform for Imaging, Targeted Drug Delivery and Organ Preservation in Transplantation
J. M. Janjic¹, E. Lambert¹, L. Liu¹, M. Herneisey¹, V. S. Gorantla²
¹School of Pharmacy, Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, ²Wake Forest Institute for Regenerative Medicine, Winston- Salem, NC
*Purpose: The goal of this project design and development of multifunctional nanomedicines to address unique and complex therapeutic outcomes in transplantation and organ preservation. Presented…
2020 American Transplant Congress
Development and Cell Surface Testing of a Novel Nanofiber Technology for Targeted Delivery of Therapeutic Regulatory T Cells
J. M. Mathew¹, S. Lee², Y. Sambandam¹, L. A. Fraser², T. D. Clemons², A. Kolberg², J. He¹, L. C. Palmer², M. T. McClendon², Z. J. Zhang¹, J. R. Leventhal¹, S. I. Stupp², L. Gallon¹
¹Surgery -Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models, and to be increased in their numbers in tolerant human…

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