ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Bioengineering"

  • 2022 American Transplant Congress

    Immunometabolism of Regulatory T Cells Enhanced by Lipid Nanoparticles

    J. S. Rink1, Y. Sambandam2, J. He2, J. Mathew3, J. R. Leventhal4, C. S. Thaxton5

    1Department of Medicine, Division of Hematology/ Oncology, Northwestern University, Chicago, IL, 2Comprehensive Transplant Center, Northwestern University, Chicago, IL, 3Northwestern University, Chicago, IL, 4Surgery, Northwestern Medicine, Chicago, IL, 5Department of Urology, Northwestern University, Chicago, IL

    *Purpose: Human regulatory T cell (Treg) metabolism is highly dependent upon a number of factors, including cholesterol obtained from circulating lipoproteins. We have developed high-density…
  • 2022 American Transplant Congress

    Vitrification of Pancreatic Islets and Transplantation

    J. S. Rao1, L. Zhan1, D. Tobolt1, M. Q. Slama2, N. Sethia1, Z. Han1, C. S. Dutcher1, Q. Peterson2, J. C. Bischof1, E. B. Finger1

    1University of Minnesota, Minneapolis, MN, 2Mayo Clinic, Rochester, MN

    *Purpose: A limitation to potential cure for diabetes through islet transplantation is insufficient islet equivalence (IEQ) from a single donor to achieve insulin independence in…
  • 2022 American Transplant Congress

    Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection

    R. R. Urie1, D. Farris2, A. Morris1, E. Lombard1, J. Z. Li3, D. Goldstein2, L. Shea1

    1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Internal Medicine, University of Michigan, Ann Arbor, MI, 3Human Genetics, University of Michigan, Ann Arbor, MI

    *Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…
  • 2022 American Transplant Congress

    Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Islet Transplantation

    J. Zhu, Y. He, Y. Wang, J. Oberholzer, L. Cai

    University of Virginia, Charlottesvle, VA

    *Purpose: Classical microencapsulation technologies for islet transplantation faces two major challenges associated with individual microcapsules. First, due to long-term gravity individual microcapsules often aggregate to…
  • 2022 American Transplant Congress

    Functional Recellularized Patient Derived Endothelium; A Human Vascular Graft Approach

    H. Tejeda Mora1, J. Willemse2, Y. den Hartog1, I. Schurink2, M. M. Verstegen2, J. de Jonge2, R. C. Minnee2, M. W. van den Hoogen2, C. C. Baan1, L. J. van der Laan2, M. J. Hoogduijn1

    1Transplant Institute - Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, 2Transplant Institute - Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: In transplantation, the endothelial lining is the first barrier between the donor organ and recipient immune system. Damaged endothelium exposes extracellular matrix (ECM) molecules…
  • 2022 American Transplant Congress

    Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture

    A. Asthana1, D. Chaimov1, R. Tamburrini2, S. J. Walker3, G. Orlando1

    1Wake Forest Baptist Medical Center, Winston-Salem, NC, 2University of Wisconsin Hospital and Clinics, Madison, WI, 3Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

    *Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…
  • 2022 American Transplant Congress

    Selective Vascular Decellularization and Endothelial Cells Replacement as a Strategy to Reduce Reperfusion Injury in Bioartificial Organs

    G. Haeublein1, G. Lombardi1, F. Caro1, R. Carla1, D. Guerrieri1, C. Incardona2, D. Casadei3, E. Chuluyan1

    1CEFYBO, Buenos Aires, Argentina, 2GADOR S.A., Buenos Aires, Argentina, 3Fundación Argentina de Trasplante, Tercer Milenio, Buenos Aires, Argentina

    *Purpose: The number of kidney transplants performed each year cannot meet the increasing demand of these organs. Several strategies aim to increasing the offer of…
  • 2022 American Transplant Congress

    Bionic Pancreas – 3D Bioprinting of a Bionic Organ with a Vascular System – Results of Transplantation in Large Animals

    M. Wszola1, M. Klak2, A. Berman3, M. Kolodziejska1, T. Bryniarski1, G. Tymicki1, T. Dobrzanski1, D. Szkopek4, K. Roszkowicz-Ostrowska5, J. Wolinski5, A. Dobrzyn6, A. Kaminski7

    1Foundation of Research and Science Development, Warsaw, Poland, 2Foundation for Research and Science Development, Warsaw, Poland, 3Polbionica Ltd., Warsaw, Poland, 4Institute of Animal Physiology and Nutrition Jan Kielanowski of the Polish Academy of Sciences,, Jabłonna, Poland, 5Institute of Animal Physiology and Nutrition Jan Kielanowski of the Polish Academy of Sciences, Jablonna, Poland, 6Laboratory of Cell Signaling and Metabolic Disorders, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland, 7Department of Transplantology and Central Tissue Bank, Medical University of Warsaw, Warsaw, Poland

    *Purpose: There is lack organs for transplantation. The transplantation of the pancreas is recommended in diabetes with complications. The combination of cell biology and 3D-bioprinting…
  • 2022 American Transplant Congress

    Bionic Pancreas – The First Results of Functionality of 3D-Bioprinted Bionic Tissue Model Transplantation with Pancreatic Islets

    M. Klak1, M. Wszola1, A. Berman1, A. Filip1, A. Kosowska2, J. Olkowska-Truchanowicz2, G. Tymicki1, M. Rachalewski1, T. Bryniarski1, M. Kolodziejska1, T. Dobrzanski3, D. Ujazdowska1, J. Wejman4, I. Uhrynowska-Tyszkiewicz2, A. Kaminski2

    1Foundation of Research and Science Development, Warsaw, Poland, 2Medical University of Warsaw, Warsaw, Poland, 3Polbionica Ltd., Warsaw, Poland, 4Center for Pathomorphological Diagnostics Ltd, Warsaw, Poland

    *Purpose: Tissue engineering is currently on advanced stage of development which gives a possibilities for novel strategy of personal treatment of type 1 diabetes. AIM:…
  • 2022 American Transplant Congress

    A Model for Medical Device Innovation in Transplantation: Using the Biodesign Process to Address the Impact of Warm Ischemic Injury

    K. Hansen1, J. Wall2

    1University of California San Francisco, San Francisco, CA, 2Stanford University, Palo Alto, CA

    *Purpose: The impact of warming during second warm-ischemia (anastomosis) of kidney transplantation has been increasingly recognized in the literature. The outsized effect on delayed graft…
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