ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Bioengineering"

  • 2022 American Transplant Congress

    Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture

    A. Asthana1, D. Chaimov1, R. Tamburrini2, S. J. Walker3, G. Orlando1

    1Wake Forest Baptist Medical Center, Winston-Salem, NC, 2University of Wisconsin Hospital and Clinics, Madison, WI, 3Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

    *Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…
  • 2022 American Transplant Congress

    Selective Vascular Decellularization and Endothelial Cells Replacement as a Strategy to Reduce Reperfusion Injury in Bioartificial Organs

    G. Haeublein1, G. Lombardi1, F. Caro1, R. Carla1, D. Guerrieri1, C. Incardona2, D. Casadei3, E. Chuluyan1

    1CEFYBO, Buenos Aires, Argentina, 2GADOR S.A., Buenos Aires, Argentina, 3Fundación Argentina de Trasplante, Tercer Milenio, Buenos Aires, Argentina

    *Purpose: The number of kidney transplants performed each year cannot meet the increasing demand of these organs. Several strategies aim to increasing the offer of…
  • 2022 American Transplant Congress

    Bionic Pancreas – 3D Bioprinting of a Bionic Organ with a Vascular System – Results of Transplantation in Large Animals

    M. Wszola1, M. Klak2, A. Berman3, M. Kolodziejska1, T. Bryniarski1, G. Tymicki1, T. Dobrzanski1, D. Szkopek4, K. Roszkowicz-Ostrowska5, J. Wolinski5, A. Dobrzyn6, A. Kaminski7

    1Foundation of Research and Science Development, Warsaw, Poland, 2Foundation for Research and Science Development, Warsaw, Poland, 3Polbionica Ltd., Warsaw, Poland, 4Institute of Animal Physiology and Nutrition Jan Kielanowski of the Polish Academy of Sciences,, Jabłonna, Poland, 5Institute of Animal Physiology and Nutrition Jan Kielanowski of the Polish Academy of Sciences, Jablonna, Poland, 6Laboratory of Cell Signaling and Metabolic Disorders, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland, 7Department of Transplantology and Central Tissue Bank, Medical University of Warsaw, Warsaw, Poland

    *Purpose: There is lack organs for transplantation. The transplantation of the pancreas is recommended in diabetes with complications. The combination of cell biology and 3D-bioprinting…
  • 2022 American Transplant Congress

    Bionic Pancreas – The First Results of Functionality of 3D-Bioprinted Bionic Tissue Model Transplantation with Pancreatic Islets

    M. Klak1, M. Wszola1, A. Berman1, A. Filip1, A. Kosowska2, J. Olkowska-Truchanowicz2, G. Tymicki1, M. Rachalewski1, T. Bryniarski1, M. Kolodziejska1, T. Dobrzanski3, D. Ujazdowska1, J. Wejman4, I. Uhrynowska-Tyszkiewicz2, A. Kaminski2

    1Foundation of Research and Science Development, Warsaw, Poland, 2Medical University of Warsaw, Warsaw, Poland, 3Polbionica Ltd., Warsaw, Poland, 4Center for Pathomorphological Diagnostics Ltd, Warsaw, Poland

    *Purpose: Tissue engineering is currently on advanced stage of development which gives a possibilities for novel strategy of personal treatment of type 1 diabetes. AIM:…
  • 2022 American Transplant Congress

    A Model for Medical Device Innovation in Transplantation: Using the Biodesign Process to Address the Impact of Warm Ischemic Injury

    K. Hansen1, J. Wall2

    1University of California San Francisco, San Francisco, CA, 2Stanford University, Palo Alto, CA

    *Purpose: The impact of warming during second warm-ischemia (anastomosis) of kidney transplantation has been increasingly recognized in the literature. The outsized effect on delayed graft…
  • 2022 American Transplant Congress

    Bioink Based on the DECM for 3D-Bioprinting of Bionic Pancreas – First Results of Animal

    M. Klak1, K. Kosowska1, T. Bryniarski1, I. Lojszczyk1, T. Dobrzanski2, G. Tymicki1, A. Filip1, A. A. Szczepankiewicz3, R. Olkowski4, A. Kosowska4, A. Berman1, A. Kaminski4, M. Wszola1

    1Foundation of Research and Science Development, Warsaw, Poland, 2Polbionica LTD, Warsaw, Poland, 3Institute of Experimental Biology M. Nencki PAN, Warsaw, Poland, 4Medical University of Warsaw, Warsaw, Poland

    *Purpose: Tissue engineering is an interdisciplinary field involving activities based on two interrelated areas: developing new methods to repair, regenerate and replace damaged tissues and…
  • 2022 American Transplant Congress

    Towards Bionic Organs: Biocompatibility Of Newly Developed Porcine Decm-based Hydrogels.

    M. Rachalewski, M. Klak, D. Ujazdowska, P. Cywoniuk, T. Dobrzanski, G. Tymicki, K. Kosowska, T. Bryniarski, A. Berman, M. Wszola

    Foundation of Research and Science Development, Warsaw, Poland

    *Purpose: There is a growing interest in fabrication of bioinks which on one hand biocompatible and on the other hand possess mechanical properties which would…
  • 2022 American Transplant Congress

    Maturation and Evaluation of 3D Printed Bionic Pancreas with a Dedicated Bioreactor

    A. Berman1, M. Klak2, T. Dobrzanski3, T. Bryniarski3, M. Kolodziejska3, G. Tymicki3, M. Wszola3

    1Polbionica Ltd., Warsaw, Poland, 2Foundation for Research and Science Development, Warsaw, Poland, 3Foundation of Research and Science Development, Warsaw, Poland

    *Purpose: The technology of 3D printing of bionic organs gives an opportunity to solve the problems of classical transplantology, such as the shortage of organs,…
  • 2022 American Transplant Congress

    Optimization of Human Liver Organoid Model for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

    Y. Park1, D. Thadasina1, K. Isidan1, K. J. Lopez1, A. Cross-Najafi1, P. Li1, H. Francis2, G. Alpini2, W. Zhang1, B. Ekser1

    1Surgery, Indiana University School of Medicine, Indianapolis, IN, 2Division of Gastroenterology & Hepatology, Indiana University School of Medicine, Indianapolis, IN

    *Purpose: The aim of our project is to develop an in vitro 3D human liver organoid (3D-HLO) model for studying nonalcoholic fatty liver disease (NAFLD)…
  • 2022 American Transplant Congress

    Plasma from Patients with Primary Focal Segmental Glomerulosclerosis Induce Development of Sclerotic Glomeruli in Kidney Organoids

    A. Kumar Gupta1, E. Minocha1, J. A. Wertheim1, L. Gallon2

    1Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, 2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: Primary focal segmental glomerulosclerosis (FSGS) is a kidney disorder resulting in end-stage renal disease that is associated with an elevated rate of recurrence after…
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