ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Apoptosis"

  • 2016 American Transplant Congress

    Lysosome Ativity Regulates LG3 Export by Apoptotic Cells.

    D. Beillevaire,1,2,4 J. Turgeon,1,2,4 E. Boilard,3,4 M. Dieudé,1,2,4 M.-J. Hébert.1,2,4

    1CRCHUM, Montréal, Canada; 2Université de Montréal, Montréal, Canada; 3CHUL, Québec, Canada; 4CNTRP - Canadian National Transplant Research Program, Edmonton, Canada.

    LG3, a C-terminal fragment of perlecan bioactive on vascular cells, has been implicated in aggravation of renal allograft rejection and vascular injury. Recently, we have…
  • 2016 American Transplant Congress

    Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.

    H. Zhou,1,2 J. Zhu,1 S. Yue,1 R. Busuttil,1 J. Kupiec-weglinski,1 L. Lu,2 Y. Zhai.1

    1Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; 2Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

    Background & AimsGlycogen synthase kinase 3 (Gsk3) a and b are ubiquitously expressed, constitutively active serine/threonine kinases, which play complex roles in cell activation, proliferation…
  • 2016 American Transplant Congress

    Short-Term Starvation Attenuates Liver Ischemia Reperfusion Injury by SIRT1-Autophagy Signaling in Mice.

    J. Rao,1 H. Zhou,1 F. Zhang,1 X. Wang,1 Y. Zhai,2 L. Lu.1

    1Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China; 2Dumont-UCLA Transplant Center, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.

    Calorie restriction or starvation (fasting) has some beneficial effects on prolongation of life and increased resistance to stress. Calorie restriction has also been shown to…
  • 2016 American Transplant Congress

    The Apoptosis of the Tracheal Epithelia Increase the Recipient's MSCs Derived Myofibroblasts in Allografts to Exacerbate Obliterative Bronchiolitis After Tracheal Transplantation in Mice.

    C. Wang,1 T. Xia,1 X. Zhang,2 K. Jiang,1 J. Wang,1 J. Nie.1

    1Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China; 2Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China.

    Background: The long-term outcome of lung transplantation is impeded by obliterative bronchiolitis (OB). However, the current treatment cannot effectively prevent the process of OB. The…
  • 2016 American Transplant Congress

    Activated Cytoprotective Mechanisms in DBD Kidneys Correlate with Kidney Function in Transplant Recipients: A Study Using Clinical Samples from the UK QUOD Biobank.

    M. Kaisar,1 L. van Dullemen,2 Z. Akhtar,1 M. Lo Faro,1 H. Huang,1 H. Leuvenink,2 B. Kessler,1 R. Ploeg.1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; 2UMCG, UMCG, Groningen, Netherlands.

    The onset of abnormal pathophysiological changes following brain death adversely impact kidney function following transplantation. Understanding the biological mechanisms that affect kidney quality will allow…
  • 2016 American Transplant Congress

    Intracellular OPN Is an Essential Protective Factor for Cardiac Endothelial Cell and the Long Term Heart Graft Survival.

    Y. Su,1,2,3 Z.-X. Zhang,1,2,3 Z.-Q. Yin,1 X.-Y. Huang,1 A. Jevnikar.1,2,3,4

    1Matthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, London Health Sciences Centre, Lodon, ON, Canada; 2Departments of Medicine, London Health Sciences Centre, Lodon, ON, Canada; 3Departments of Pathology, London Health Sciences Centre, London, ON, Canada.

    [Background] Endothelial cell (EC) injury is central to cardiac allograft vasculopathy and premature graft loss. Osteopontin (OPN) is a multifunctional anti-apoptotic protein that is involved…
  • 2016 American Transplant Congress

    The 20S Proteasome, Active within Exosome-Like Vesicles Released by Apoptotic Cells Accelerates Rejection.

    M. Dieudé,1,4,5 C. Bell,2,5 J. Turgeon,1,5 D. Beillevaire,1,4,5 S. Qi,1,5 E. Boilard,3,5 P. Thibault,2,5 M.-J. Hébert.1,4,5

    1Research Centre Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Canada; 2Institute for research in immunology and cancer (IRIC), Montreal, Canada; 3Centre de Recherche du CHU de Québec, Québec, Canada; 4Université de Montréal, Montréal, Canada; 5Canadian National Transplant Research Program, Edmonton, Canada.

    Apoptotic bodies (ApoBodies) and apoptotic exosome-like MV (ApoExo) released by apoptotic endothelial cells in vitro were purified by sequential centrifugation and analysed by electron microscopy…
  • 2015 American Transplant Congress

    Phenotype of Renal Tubular Cell Death During Delayed Graft Function

    S. Jain,1 R. Plenter,1 T. Nydam,1 C. Ruller,1 C. Edelstein,1,2 A. Jani.1,2

    1University of Colorado, Aurora, CO; 2Veterans Affairs Medical Center, Denver, CO.

    Background: Delayed graft function (DGF) independently predicts reduced 5 yr kidney transplant survival. Treatments of DGF are lacking. Cold ischemia (CI) is a significant risk…
  • 2015 American Transplant Congress

    A Novel Signaling Approach for the Prevention of Ischemia/Reperfusion Injury (IRI)

    S. Khalid,1 M. Haller,1 K. Koziel,1 M. Enthammer,1 M. Hermann,2 M. Thurner,1 L. Kremser,3 H. Lindner,3 J. Troppmair.1

    1VTT, DSL, Innsbruck Medical University, Innsbruck, Austria; 2Anestesiology and Critical Care Medicine, Innsbruck Medical Unversity, Innsbruck, Austria; 3Division of Clinical Biochemistry, Innsbruck Medical University, Innsbruck, Austria.

    Mitochondrial reactive oxygen species (ROS) produced during early reperfusion are important triggers for the development of ischemia/reperfusion injury (IRI). However, antioxidants yielded little clinical benefit…
  • 2015 American Transplant Congress

    Engagement of the Vasopressin Receptor On Hepatocytes Protects Liver from Ischemia-Reperfusion Injury Via the WNT-β-Catenin-SGK1-FOXO Pathway

    X. Liu,1 T. Billiar,2 R. Tao.1

    1Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; 2Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

    The synthetic vasopressin analogue, terlipressin, has been extensively used in the management of certain complications associated with end-stage liver diseases (ESLDs), however concerns have been…
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