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American Transplant Congress abstracts

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Articles tagged "Apoptosis"

  • 2020 American Transplant Congress

    Induction of Transplant Tolerance by Modulating the Metabolic Stress Pathways

    X. Xiao, L. Zhang, Y. Ying, Y. Wang, P. Arnold, Z. Zhang, X. Li

    Houston Methodist Research Institute, Houston, TX

    *Purpose: T cell activation and effector differentiation precede graft rejection, and this process is associated with robust metabolic burst to meet the energy demand of…
  • 2020 American Transplant Congress

    Prophylactic Treatment with Antioxidant Nanoparticles Attenuate Ischemia/Reperfusion Injury in BALB/c Mice

    S. Yoon1, K. Lee1, W. Hwang1, S. Yun1, K. Yoon2

    1Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, 2Chemistry, Hannam University, Daejeon, Korea, Republic of

    *Purpose: Kidney is more susceptible to hypoxic damage than other organ because kidney tissue consumes most of oxygen to move various solute across membrane. Ischemia/reperfusion…
  • 2020 American Transplant Congress

    Cyclophilin-D Inhibition Mitigates Cardiac Allograft Ischemia-Reperfusion Injury and Rejection

    A. Qamar1, P. McLeod2, J. Jiang2, X. Huang2, A. M. Jevnikar2, Z. Zhang2

    1Pathology & Laboratory Medicine, University of Western Ontario, London, ON, Canada, 2London Health Sciences Center, London, ON, Canada

    *Purpose: The clinical relevance of ischemia-reperfusion injury (IRI) in the context of organ transplantation is well-established. IRI is associated with various forms of programmed cell…
  • 2020 American Transplant Congress

    XIAP Enhances Xenoislet Survival: Novel Models to Evaluate Pretransplantation Gene Modifications

    G. R. Devi1, Z. Fitch1, M. Song1, M. Ribeiro1, A. McGowan1, X. Luo2, B. H. Collins1, A. D. Kirk1

    1Department of Surgery, Duke Univesity School of Medicine, Durham, NC, 2Division of Nephrology, Duke Univesity School of Medicine, Durham, NC

    *Purpose: Porcine islet xenotransplantation offers a reliable and near limitless supply of islets for the treatment of type 1 diabetes. Intraportal infusion of cells exposes…
  • 2020 American Transplant Congress

    Inhibiting NLRP3 Inflammasome Ameliorates Glucose Fluctuation Through Reducing Apoptosis and Infiltration of Inflammatory Cells after Intraportal Islet Transplantation in Rodent Model

    G. Yoshimatsu, T. Matsuoka, K. Chinen, N. Sakata, S. Kodama

    Department of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    *Purpose: Islet transplantation is a useful treatment option for insulin dependent diabetes mellitus with severe hypoglycemic event. However, intraportal islet transplantation is known to induce…
  • 2020 American Transplant Congress

    Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats

    H. Lin1, S. Dai2, W. Liu3, X. Lin2, B. Yu2, S. Chen3, S. Liu2, J. Tang2

    1Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, 2Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, 3Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China

    *Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…
  • 2020 American Transplant Congress

    Predominant Role of Microvascular Injury and Rarefaction Function as Drivers of Progressive Renal Damage and Fibrosis Post Mild and Severe Acute Ischemia-Reperfusion Injury

    S. Lan1, B. Yang1, J. Sabo-Vatasescu2, M. Bourgault2, A. Karakeussian-Rimbaud3, J. Turgeon3, S. Qi1, N. Patey4, M. Dieudé5, M. Hébert1

    1Medicine Faculty, CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada, 2CRCHUM, Montreal, QC, Canada, 3CRCHUM, CDTRP, Montreal, QC, Canada, 4Medicine Faculty, CRCHUM, Saint Justine Hospital, University of Montreal, Montreal, QC, Canada, 5CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Here, we characterize the different cell deaths in tubular and microvascular compartments…
  • 2020 American Transplant Congress

    Protective Effect of Fucoidan Against Tacrolimus-Induced Nephrotoxicity in LLC-PK1 Cells

    H. J. Jang

    Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of

    *Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
  • 2020 American Transplant Congress

    Immunomodulation with FasL Presenting Biomaterials Achieves Long-Term Survival of Allogeneic Islets in the Absence of Chronic Immunosuppression in a Non-Human Primate Model

    J. Lei1, H. Deng1, T. Chen1, K. Lee1, C. Peters1, Z. Yang1, K. Deng1, G. Rickert1, I. Rosales1, N. Serifis1, M. Coronel2, M. Hunckler2, E. Yolcu3, H. Shirwan3, A. García2, J. Markmann1

    1Surgery, Mass General, Boston, MA, 2School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 3School of Mechanical Engineering, University of Louisville School of Medicine, Louisville, KY

    *Purpose: The full potential of islet transplantation will only be realized by the development of tolerogenic strategies that obviate the need for maintenance immunosuppressants. We…
  • 2020 American Transplant Congress

    Caspase-1 Knockout Mice Have Increased Survival after Cold Ischemia in a Murine Kidney Transplant Model

    S. Jain1, R. Plenter2, T. Nydam2, A. Jani1

    1Renal, University of Colorado, Aurora, CO, 2Transplant Microsurgery Program, University of Colorado, Aurora, CO

    *Purpose: Prolonged cold ischemia (CI) is a known risk factor for acute kidney injury (AKI) after kidney transplantation. However, the mechanism by which CI leads…
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