2018 American Transplant Congress
QPI-1002, a siRNA Targeting p53: Improvement in Outcomes Following Acute Kidney Injury (AKI): Cardiac Surgery to AKI Donors
Background: QPI-1002 has been observed to statistically reduce the incidence, severity and duration of AKI in a large Phase 2 study of AKI following cardiac…2018 American Transplant Congress
Apoptotic Exosome-Like Vesicles Induce Endothelial Cell Plasticity
Acute vascular rejection of renal allografts is associated with increased endothelial apoptosis which contributes to the development of transplant vasculopathy. We previously showed that apoptotic…2018 American Transplant Congress
Recombinant Thrombomodulin alpha Attenuates Kidney Graft Damage after Long Cold Ischemia Time in a Rat Kidney Transplant Model
Objectives: Thrombomodulin (TM) extensively expresses on the endothelial cells in the steady state and is known to prevent hypercoagulation via combining with thrombin and inactivating…2018 American Transplant Congress
Linking Donor Ischemia Reperfusion Injury (IRI) to Costimulatory Blockade Resistant Murine Heart Graft Rejection through Complement-Initiated Necroptosis
We previously showed that prolonged cold ischemic storage (CIS) of donor B6 hearts results in complement dependent, CTLA4Ig-resistant rejection in BALB/c recipients. In this system,…2018 American Transplant Congress
MERTK Mediates Transplant Tolerance via IFN-a Regulation of MDSCs and Tregs
Northwestern University Feinberg School of Medicine, Chicago.
Introduction: MERTK is one of the TAM receptor tyrosine kinases (RTKs) that mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune…2018 American Transplant Congress
Enhancement of Intrinsic Apoptosis via Bcl-2 Inhibition Promotes Induction of Robust Mixed Chimerism and Renal Allograft Tolerance without Myelosuppression in Nonhuman Primates
Background: Successful induction of mixed chimerism (MC) and renal allograft tolerance has been achieved in both nonhuman primate (NHP) and man following conditioning that included…2018 American Transplant Congress
Involvement of Aldehyde Dehydrogenase 2 (ALDH2) in Fatty Liver Graft Protection Mechanisms against Cold Ischemic Injury
Aldehyde dehydogenase (ALDH2) is a mitochondrial enzyme that recently has been involved in the cardioprotection against ischemia injury. No data are reported on the potential…2018 American Transplant Congress
In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury
Background:M1-Macrophage polarization has been studied as a potential target to decrease inflammatory response in sepsis and inflammation-related diseases. Its role in the setting of inflammatory…2018 American Transplant Congress
Overexpression of BAX, NOL3, and XIAP Apoptotic Genes Participates in Calcineurin Inhibitors Nephrotoxicity: New Insights into Chronic Allograft Dysfunction
Introduction: Calcineurin inhibitors toxicity (CNIT) is a factor that limit the outcome of renal transplantation graft. The hypoxia causes histological data as nodular hyalinosis, hyalinosis,…2018 American Transplant Congress
Noninvasive Detection of Infection and Rejection in Renal Transplant Patients
About 35% of patients would suffer actue rejection or infectionin in two years after reanl trandplantation.Cell-free DNA (cfDNA) is a new biomarker to evluate health…
American Transplant Congress abstracts