Articles tagged "Apoptosis"

2022 American Transplant Congress
Hepatocyte Notch1 Regulates Autophagy/DR5 Axis and Inhibits Cell Death in Mouse and Human Liver Transplantation
H. Hirao, K. Kadono, H. Kojima, K. J. Dery, D. G. Farmer, F. M. Kaldas, B. Ke, J. Kupiec-Weglinski
UCLA, Los Angeles, CA
*Purpose: Liver ischemia-reperfusion injury (IRI) is a major risk factor of early graft dysfunction and predisposes to rejection in orthotopic liver transplantation (OLT). Although Notch1…
2022 American Transplant Congress
Apoptotic Exosome-Like Vesicles Aggravate Inflammation and Renal Injury After Ischemia-Reperfusion
I. Kaci¹, S. Lan¹, H. Kim¹, A. Karakeussian Rimbaud¹, F. Migneault¹, J. Turgeon¹, N. Patey², M. Dieudé¹, M. Hébert¹
¹Research Centre, Centre hospitalier de l’Université de Montréal, Montreal, QC, Canada, ²Research Centre, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and chronic kidney disease (CKD). Damage to microvascular peritubular capillaries (PTC) is…
2022 American Transplant Congress
Investigating RNA Interference-Mediated Inhibition of Liver Ischemia Reperfusion Injury During Liver Preservation
J. E. Buchwald¹, D. Echeverria², J. Sousa², N. McHugh², A. Khvorova², P. N. Martins³
¹RNA Therapeutics Institute, Department of Surgery, University of Massachusetts Chan Medical School, Worcester, MA, ²RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, ³Department of Surgery, University of Massachusetts Chan Medical School, Worcester, MA
*Purpose: Liver transplantation cures acute end-stage and chronic liver diseases, yet current strategies of organ preservation including static cold storage (SCS) and machine perfusion (MP)…
2022 American Transplant Congress
Dual Therapy with Esculin and Erythropoietin Attenuates Renal Ischemia-Reperfusion Injury via P2x7 Receptor and Nlrp3 Inflammasome Inhibition, and Pi3k/akt Activation
E. Hafiz¹, W. H. El-Maadawy², M. Hassan³, M. H. Badawy⁴, S. Eldahshan⁴, A. AbuSeada⁵
¹Clinical Research Laboratory Department, Theodor Bilharz Research Institute, Giza, Egypt, ²Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt, ³Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt, ⁴Urology Department, Theodor Bilharz Research Institute, Giza, Egypt, ⁵Anesthesia Department, Theodor Bilharz Research Institute, Giza, Egypt
*Purpose: Renal ischemia/reperfusion (RI/R) is an inevitable condition during renal transplantation with critical clinical outcomes. Accordingly, effective therapies are crucially required.*Methods: In this study, the…
2022 American Transplant Congress
Understanding the Response of Human Lung Microvascular Endothelial Cells During Lung Transplantation via an In Vitro Model of Ischemia Reperfusion Injury
L. Chacon Alberty¹, M. King¹, G. Loor², E. Curty¹, C. Hochman-Mendez¹
¹Regenerative Medicine Research, Texas Heart Institute, Houston, TX, ²Baylor College of Medicine - Lung Transplant, Houston
*Purpose: Lung Transplantation (LTx) is a therapeutic option for patients with end-stage lung disease. One of the major complications is primary graft dysfunction largely attributed…
2022 American Transplant Congress
FasL-Presenting PEG Microgels Supports Sustained Graft Survival in Nonhuman Primates in the Absence of Continuous Immunosuppression
E. S. Yolcu¹, J. Lei², M. M. Coronel³, H. Deng⁴, Z. Yang⁴, A. Zhang⁴, T. Chen⁵, K. Lee⁴, C. Peters⁴, I. Rosales⁴, Z. Wang⁴, J. Markmann⁴, A. Garcia³, H. Shirwan¹
¹University of Missouri at Columbia, Columbia, MO, ²Surgery, Mass General, Boston, MA, ³Georgia Institute of Technology, Atlanta, GA, ⁴Massachusetts General Hospital, Boston, MA, ⁵Xiamen University Medical School, Xiamen, China
*Purpose: Broad application of allogeneic islets for T1D treatment is curtailed by the use of chronic immunosuppression to control rejection. Teff cells are the major…
2022 American Transplant Congress
Tumor Suppressor Role of the Caveolar α1-na/k-atpase Signalosome in Nash Related Hepatocellular Carcinoma (HCC)
U. Udoh¹, M. Banerjee¹, J. D. Sanabria¹, P. K. Rajan¹, M. Schade², J. A. Sanabria³, S. Pierre³, J. R. Sanabria⁴
¹Surgery, Marshall Institute for Interdisciplinary Research, Barboursville, WV, ²Medicine, Joan C. Edwards School of Medicine, Marshall University, Barboursville, WV, ³Surgery, Joan C. Edwards School of Medicine, Marshall University, Barboursville, WV, ⁴Surgery, Joan C. Edwards School of Medicine, Marshall University and Case Western Reserve University, Barboursville, WV
*Purpose: HCC is the second and fastest-growing cause of cancer- related mortality worldwide, with an estimate of 0.84million cases/year. In the Western countries, due to…
2022 American Transplant Congress
Deletion of Fibroblastic Reticular Cell Derived Laminin A4 Impairs Lymph Node Vasculature and Conduits
L. Li¹, M. Shirkey¹, W. Piao¹, A. Kensiski¹, V. Saxena¹, T. Zhang¹, X. Li², J. Zhao², S. Gavzy¹, R. Abdi², J. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Fibroblastic reticular cells (FRCs) support lymph node (LN) structure by producing various functional extracellular matrix (ECM) components. We hypothesized that FRCs and their ECM…
2022 American Transplant Congress
Hepatocyte SIRT1 Regulation of Apoptosis-Mediated Pyroptosis Cell Death in Mouse and Human Liver Transplantation
K. Kadono¹, H. Hirao¹, H. Kojima¹, K. J. Dery¹, X. Li², J. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: Cold static preservation is a gold-standard in orthotopic liver transplantation (OLT). However, the role of hepatocyte-specific SIRT1 transcriptional regulation of cell death programs during…
2022 American Transplant Congress
NecroX-7 Ameliorate FK506-Induced Nephrotoxicity in LLC-PK1 Cells (Pig Kidney Epithelial Cells)
H. J. Jang
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of
*Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…

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