Articles tagged "Apoptosis"

2016 American Transplant Congress
Lysosome Ativity Regulates LG3 Export by Apoptotic Cells.
D. Beillevaire,^1,2,4 J. Turgeon,^1,2,4 E. Boilard,^3,4 M. Dieudé,^1,2,4 M.-J. Hébert.^1,2,4
¹CRCHUM, Montréal, Canada; ²Université de Montréal, Montréal, Canada; ³CHUL, Québec, Canada; ⁴CNTRP - Canadian National Transplant Research Program, Edmonton, Canada.
LG3, a C-terminal fragment of perlecan bioactive on vascular cells, has been implicated in aggravation of renal allograft rejection and vascular injury. Recently, we have…
2016 American Transplant Congress
Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.
H. Zhou,^1,2 J. Zhu,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-weglinski,¹ L. Lu,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsGlycogen synthase kinase 3 (Gsk3) a and b are ubiquitously expressed, constitutively active serine/threonine kinases, which play complex roles in cell activation, proliferation…
2016 American Transplant Congress
Short-Term Starvation Attenuates Liver Ischemia Reperfusion Injury by SIRT1-Autophagy Signaling in Mice.
J. Rao,¹ H. Zhou,¹ F. Zhang,¹ X. Wang,¹ Y. Zhai,² L. Lu.¹
¹Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²Dumont-UCLA Transplant Center, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Calorie restriction or starvation (fasting) has some beneficial effects on prolongation of life and increased resistance to stress. Calorie restriction has also been shown to…
2016 American Transplant Congress
The Apoptosis of the Tracheal Epithelia Increase the Recipient's MSCs Derived Myofibroblasts in Allografts to Exacerbate Obliterative Bronchiolitis After Tracheal Transplantation in Mice.
C. Wang,¹ T. Xia,¹ X. Zhang,² K. Jiang,¹ J. Wang,¹ J. Nie.¹
¹Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China; ²Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China.
Background: The long-term outcome of lung transplantation is impeded by obliterative bronchiolitis (OB). However, the current treatment cannot effectively prevent the process of OB. The…
2016 American Transplant Congress
Activated Cytoprotective Mechanisms in DBD Kidneys Correlate with Kidney Function in Transplant Recipients: A Study Using Clinical Samples from the UK QUOD Biobank.
M. Kaisar,¹ L. van Dullemen,² Z. Akhtar,¹ M. Lo Faro,¹ H. Huang,¹ H. Leuvenink,² B. Kessler,¹ R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²UMCG, UMCG, Groningen, Netherlands.
The onset of abnormal pathophysiological changes following brain death adversely impact kidney function following transplantation. Understanding the biological mechanisms that affect kidney quality will allow…
2016 American Transplant Congress
Intracellular OPN Is an Essential Protective Factor for Cardiac Endothelial Cell and the Long Term Heart Graft Survival.
Y. Su,^1,2,3 Z.-X. Zhang,^1,2,3 Z.-Q. Yin,¹ X.-Y. Huang,¹ A. Jevnikar.^1,2,3,4
¹Matthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, London Health Sciences Centre, Lodon, ON, Canada; ²Departments of Medicine, London Health Sciences Centre, Lodon, ON, Canada; ³Departments of Pathology, London Health Sciences Centre, London, ON, Canada.
[Background] Endothelial cell (EC) injury is central to cardiac allograft vasculopathy and premature graft loss. Osteopontin (OPN) is a multifunctional anti-apoptotic protein that is involved…
2016 American Transplant Congress
The 20S Proteasome, Active within Exosome-Like Vesicles Released by Apoptotic Cells Accelerates Rejection.
M. Dieudé,^1,4,5 C. Bell,^2,5 J. Turgeon,^1,5 D. Beillevaire,^1,4,5 S. Qi,^1,5 E. Boilard,^3,5 P. Thibault,^2,5 M.-J. Hébert.^1,4,5
¹Research Centre Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Canada; ²Institute for research in immunology and cancer (IRIC), Montreal, Canada; ³Centre de Recherche du CHU de Québec, Québec, Canada; ⁴Université de Montréal, Montréal, Canada; ⁵Canadian National Transplant Research Program, Edmonton, Canada.
Apoptotic bodies (ApoBodies) and apoptotic exosome-like MV (ApoExo) released by apoptotic endothelial cells in vitro were purified by sequential centrifugation and analysed by electron microscopy…
2015 American Transplant Congress
Phenotype of Renal Tubular Cell Death During Delayed Graft Function
S. Jain,¹ R. Plenter,¹ T. Nydam,¹ C. Ruller,¹ C. Edelstein,^1,2 A. Jani.^1,2
¹University of Colorado, Aurora, CO; ²Veterans Affairs Medical Center, Denver, CO.
Background: Delayed graft function (DGF) independently predicts reduced 5 yr kidney transplant survival. Treatments of DGF are lacking. Cold ischemia (CI) is a significant risk…
2015 American Transplant Congress
A Novel Signaling Approach for the Prevention of Ischemia/Reperfusion Injury (IRI)
S. Khalid,¹ M. Haller,¹ K. Koziel,¹ M. Enthammer,¹ M. Hermann,² M. Thurner,¹ L. Kremser,³ H. Lindner,³ J. Troppmair.¹
¹VTT, DSL, Innsbruck Medical University, Innsbruck, Austria; ²Anestesiology and Critical Care Medicine, Innsbruck Medical Unversity, Innsbruck, Austria; ³Division of Clinical Biochemistry, Innsbruck Medical University, Innsbruck, Austria.
Mitochondrial reactive oxygen species (ROS) produced during early reperfusion are important triggers for the development of ischemia/reperfusion injury (IRI). However, antioxidants yielded little clinical benefit…
2015 American Transplant Congress
Engagement of the Vasopressin Receptor On Hepatocytes Protects Liver from Ischemia-Reperfusion Injury Via the WNT-β-Catenin-SGK1-FOXO Pathway
X. Liu,¹ T. Billiar,² R. Tao.¹
¹Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; ²Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
The synthetic vasopressin analogue, terlipressin, has been extensively used in the management of certain complications associated with end-stage liver diseases (ESLDs), however concerns have been…