Articles tagged "Apoptosis"

2016 American Transplant Congress
Exosome-Like Vesicles Released in Association with Tissue Injury Trigger Anti-LG3 Production.
M. Dieudé,^1,2,3 J. Turgeon,^1,3 B. Yang,^1,2,3 L. Pomerleau,^1,3 K. Hamelin,^1,3 S. Lan,^1,2,3 S. Qi,^1,3 D. Gingras,^1,3 W. Dhari,¹ A. Rivard,¹ M.-J. Hébert.^1,2,3
¹Research Centre, Centre hospitalier de l'Université de Montréal, Montréal, Canada; ²Université de Montréal, Montréal, Canada; ³Canadian National Transplantation Research Program, Edmonton, Canada.
Pre-transplant levels of autoantibodies to perlecan/LG3 predict poor allograft outcomes in renal transplant patients. We showed previously thatapoptotic exosome-like vesicles (ApoExo) enhance anti-LG3 production and…
2016 American Transplant Congress
Lysosome Ativity Regulates LG3 Export by Apoptotic Cells.
D. Beillevaire,^1,2,4 J. Turgeon,^1,2,4 E. Boilard,^3,4 M. Dieudé,^1,2,4 M.-J. Hébert.^1,2,4
¹CRCHUM, Montréal, Canada; ²Université de Montréal, Montréal, Canada; ³CHUL, Québec, Canada; ⁴CNTRP - Canadian National Transplant Research Program, Edmonton, Canada.
LG3, a C-terminal fragment of perlecan bioactive on vascular cells, has been implicated in aggravation of renal allograft rejection and vascular injury. Recently, we have…
2016 American Transplant Congress
Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.
H. Zhou,^1,2 J. Zhu,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-weglinski,¹ L. Lu,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsGlycogen synthase kinase 3 (Gsk3) a and b are ubiquitously expressed, constitutively active serine/threonine kinases, which play complex roles in cell activation, proliferation…
2016 American Transplant Congress
Short-Term Starvation Attenuates Liver Ischemia Reperfusion Injury by SIRT1-Autophagy Signaling in Mice.
J. Rao,¹ H. Zhou,¹ F. Zhang,¹ X. Wang,¹ Y. Zhai,² L. Lu.¹
¹Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²Dumont-UCLA Transplant Center, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Calorie restriction or starvation (fasting) has some beneficial effects on prolongation of life and increased resistance to stress. Calorie restriction has also been shown to…
2016 American Transplant Congress
The Apoptosis of the Tracheal Epithelia Increase the Recipient's MSCs Derived Myofibroblasts in Allografts to Exacerbate Obliterative Bronchiolitis After Tracheal Transplantation in Mice.
C. Wang,¹ T. Xia,¹ X. Zhang,² K. Jiang,¹ J. Wang,¹ J. Nie.¹
¹Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China; ²Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China.
Background: The long-term outcome of lung transplantation is impeded by obliterative bronchiolitis (OB). However, the current treatment cannot effectively prevent the process of OB. The…
2016 American Transplant Congress
Activated Cytoprotective Mechanisms in DBD Kidneys Correlate with Kidney Function in Transplant Recipients: A Study Using Clinical Samples from the UK QUOD Biobank.
M. Kaisar,¹ L. van Dullemen,² Z. Akhtar,¹ M. Lo Faro,¹ H. Huang,¹ H. Leuvenink,² B. Kessler,¹ R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²UMCG, UMCG, Groningen, Netherlands.
The onset of abnormal pathophysiological changes following brain death adversely impact kidney function following transplantation. Understanding the biological mechanisms that affect kidney quality will allow…
2016 American Transplant Congress
Intracellular OPN Is an Essential Protective Factor for Cardiac Endothelial Cell and the Long Term Heart Graft Survival.
Y. Su,^1,2,3 Z.-X. Zhang,^1,2,3 Z.-Q. Yin,¹ X.-Y. Huang,¹ A. Jevnikar.^1,2,3,4
¹Matthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, London Health Sciences Centre, Lodon, ON, Canada; ²Departments of Medicine, London Health Sciences Centre, Lodon, ON, Canada; ³Departments of Pathology, London Health Sciences Centre, London, ON, Canada.
[Background] Endothelial cell (EC) injury is central to cardiac allograft vasculopathy and premature graft loss. Osteopontin (OPN) is a multifunctional anti-apoptotic protein that is involved…
2015 American Transplant Congress
The 20S Proteasome Is Active in Apoptotic Nanovesicles and Controls Anti-LG3 Antibody Production
M. Dieudé,^1,4 C. Bell,^2,4 J. Turgeon,^1,4 D. Beillevaire,^1,4 K. Hamelin,^1,4 S. Qi,^1,4 N. Pallet,^1,4 C. Rondeau,³ D. Gingras,³ M. Desjardins,³ P. Thibault,^2,4 M.-J. Hébert.^1,4
¹Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; ²Institute for Research in Immunology and Cancer (IRIC), Montreal, QC, Canada; ³Université de Montréal, Montreal, QC, Canada; ⁴Canadian National Transplant Research Program (CNTRP), Montreal, Canada.
Humoral autoreactivity to apoptotic cells and perlecan/LG3, a proteoglycan fragment released by apoptotic cells, predicts poor allograft outcomes in renal transplant patients. How apoptotic cells…
2015 American Transplant Congress
Anti-LG3 Antibodies Aggravate Ischemia-Reperfusion Injury
B. Yang,¹ K. Hamelin,¹ L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ N. Patey,² M.-J. Hébert.¹
¹Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Université de Montréal, Montréal, Canada; ²Department of Pathology, CHU Ste-Justine Université de Montréal, Montréal, Canada.
Ischemia-Reperfusion Injury (IRI) is a significant cause of renal allograft dysfunction and a risk factor for poor long-term graft outcomes. Microvascular injury is an important…
2015 American Transplant Congress
Decreased Expression of Mitochondrial Aldehyde Dehydrogenase 2 Induces Liver Injury Via Activation of the MAPK Pathway in Grafts from Brain-Dead Donors
Z. Zhong,¹ S. Ye,¹ Y. Xiong,¹ X. Fan,¹ W. Huang,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Objective: To determine the role of ALDH2 in the injury of liver from brain-dead donors.Methods: Using brain-dead rabbit model, the expression of ALDH2 and apoptosis…