2013 American Transplant Congress

May 18-22, 2013 in Seattle, Washington

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T Cell Help Is Critical in Determining Mode of Alloantibody-Mediated Allograft Rejection

M. Chhabra, C. Callaghan, M. Negus, S. Rehakova, S. Qureshi, E. Bolton, J. Bradley, G. Pettigrew
T Cell Senescence and Accelerated Immunologic Aging in Children Awaiting Kidney Transplantation

R. George, A. Mehta, L. Stempora, B. Johnson, J. Cheeseman, P. Sebastian, B. Warshaw, A. Kirk
T-Cell Depletion by Anti-CD3ε Is Associated with Dyshomeostasis in the Immature B-Cell Pool

G. Wu, N. Chai, S. Jordan, A. Klein
T-Cell Mediated Rejections Do Not Induce De Novo Donor Specific Antibodies in Non-Sensitized Kidney Transplant Recipients: A Longitudinal Cohort Analysis

J. Chemouny, C. Suberbielle, A. Loupy, C. Legendre, D. Anglicheau
Tacrolimus Concentration Variability Is Associated with Delayed Graft Function and Diminished Renal Function in Kidney Transplant Recipients

C. Makowski, N. Pilch, H. Meadows, C. Bratton, J. McGillicuddy, K. Chavin, P. Baliga, D. Taber
Tacrolimus Dose and Trough Blood Levels in a US Liver Transplant Population

B. Pinsky, M. Tran, A. Riedel
Tacrolimus Granules Use in Kidney Transplanted Infants. Dose and Safety

R. Vilalta, E. Lara, A. Madrid, M. Muñoz, S. Chocron, G. Ariceta, R. Vilalta
Tacrolimus Is More Than Just a Calcineurin Inhibitor: It Suppresses NF-κB Activation in Human T Cells

R. Vafadari, R. Kraaijeveld, W. Weimar, C. Baan
Tacrolimus Metabolism Rate Influences the Kidney Function after Liver Transplantation, The

G. Thölking, L. Siats, C. Fortmann, S. Beckebaum, V. Cicinnati, H. Gerth, H. Wolters, C. Anthoni, J. Brockmann, H. Pavenstädt, H. Schmidt, B. Suwelack, I. Kabar
Tacrolimus Predose Concentrations Do Not Predict the Risk of Acute Rejection after Renal Transplantation: A Pooled Analysis from Three Randomised-Controlled Clinical Trials

R. Bouamar, N. Shuker, D. Hesselink, W. Weimar, H. Ekberg, B. Kaplan, C. Bernasconi, T. van Gelder
Tacrolimus-Induced Diabetes Compared to Cyclosporine May Lead to More Diabetic Complications Post Heart Transplant

J. Patel, M. Kittleson, M. Rafiei, A. Osborne, D. Chang, L. Czer, J. Kobashigawa
Targeting Inositol-Requiring Enzyme 1α in Prevention of Donor Specific Antibody (DSA) Mediated Rejection

J. Ye, Q. Qiu, J. Wang, D. Fang, Z. Zhang
Targeting of mTORC2 in DC Elicits an Enhanced Pro-Inflammatory Profile and Th17 Alloresponse

D. Raich-Regue, B. Rosborough, K. Lee, M. Boothby, H. Turnquist, A. Thomson
Tauroursodeoxycholic Acid Alleviate Ischemia-Reperfusion Injury in Donation after Cardiac Death Liver Transplantation

L. Lu, J. Rao, G. Li, X. Pan, X. Wang
TBX21 Polymorphism Influence BK Virus Viremia in Solid Organ Transplant Recipients (SOT)

A. Wójtowicz, S. Bibert, O. Manuel, D. Golshayan, C. Berger, K. Boggian, C. Garzoni, M. Weisser, C. Van Delden, N. Mueller, P. Meylan, M. Pascual, H. Hirsch, P. Bochud, the Swiss Transplant Cohort Study (STCS)
TCMR Is Underdiagnosed in BK Virus Nephropathy: A Tale of 2 Populations

G. Einecke, J. Reeve, P. Halloran
TCR-Directed Immune Therapy Restores Self Tolerance and Significantly Prolongs Islet Allograft Survival in Diabetic NOD Mice

P. Schroder, M. Khattar, R. Deng, C. Baum, B. Mierzejewska, S. Stepkowski
Technical Variant Liver Transplantation or Whole Liver Transplantation for Pediatric Patients? A Meta-Analysis

Z. Guo, W. Ju, Y. Wang, X. He
Telaprevir Based Combination Therapy for the Treatment of Recurrent HCV in Liver Transplant Recipients: Promising Early Results, Late Disappointment

B. Gelb, R. Layman, L. Teperman
Telomere Length of Living Kidney Donors and Recipients and Chronic Graft Dysfunction in Kidney Transplants

W. Oetting, W. Guan, W. Wildenbush, P. Jacobson, A. Matas, A. Israni, DeKAF Investigators
Ten-Year Experience in Pediatric Renal Transplant Using Thymoglobulin Induction and Steroid Minimization

J. Warejko, S. Hmiel
Tetrahydrobiopterin Prevents Brain Death Exacerbated Ischemia Reperfusion Injury in Pancreatic Isografts

R. Oberhuber, P. Ritschl, C. Fabritius, A. Nguyen, B. Cardini, M. Hermann, P. Obrist, E. Werner, M. Maglione, J. Pratschke, K. Kotsch
Th17 Memory Cells Are More Dependent on Coinhibition by CTLA-4 Than Th1 Memory Cells and Are Associated with Rejection in Patients Treated with Belatacept

S. Krummey, J. Cheeseman, P. Jang, A. Mehta, A. Kirk, C. Larsen, M. Ford
Theaflavin (TF) Ameliorates Kidney Ischemia-Reperfusion Injury in Mice

J. Hou, T. Sato, Z. Fang, Q. Ding, X. Li
Therapeutic Dosing of Mycophenolate Mofetil (MMF) in Renal Allograft Recipients Decreases with Increasing Age

S. Narins, R. Scott, M. Waybill, H. Yang
Therapeutic Management and Outcome of the Novo Prostate Cancer in Renal Transplant Recipients

P. Carta, M. Zanazzi, D. Villari, B. Detti, G. Nicita, E. Minetti
Therapeutic Mycophenolic Acid Area-Under-Curve (MPA AUC) Levels Abolish Donor-Specific Antibody Formation in Established and De Novo Renal Transplant Patients

M. Waybill, S. Narins, R. Scott, H. Yang
Therapy with mTOR Inhibitors in Polyomavirus Nephropathy: A Five Year Follow Up

A. Esteves, L. Camargo, L. Ulisses, G. Rivelli, M. Mazzali
There Is No Difference in Patient Survival after Liver Transplantation between Induction with Rabbit ATG and Basiliximab in Recipients with HCV, However, There Appears To Be Less Severe Fibrosis with rATG

M. Montenovo, J. Brandenberger, R. Bakthavatsalam, J. Haldorson, A. Dick, J. Perkins, R. Carithers, R. Bhattacharya, L. Yu, I. Liou, C. Landis, M. Yey, J. Reyes, S. Rayhill
Threatened Kidney Allograft: Use of mTOR- Inhibitor Increases All Cause Mortality

V. Reddivari, M. Weir, R. Wali
Three Genotypically Distinct Strains of Pneumocystis Jirovecii Caused an Outbreak of Pneumocystis Pneumonia in Renal and Liver Transplant Recipients

A. Rostved, M. Sassi, J. Kurtzhals, S. Sørensen, A. Rasmussen, C. Ross, E. Gogineni, C. Huber, G. Kutty, J. Kovacs, J. Helweg-Larsen
Three-Gene Signature of Tolerance for Clinical Application in Kidney Transplant Recipients

I. Rebollo-Mesa, P. Mobillo, E. Nova-Lamperti, S. Norris, Y. Kamra, M. Runglall, GAMBIT Consortium, Immune Tolerance Network, Indices of Tolerance Consortium, G. Lord, R. Lechler, M. Hernandez-Fuentes
Three-Year Safety and Efficacy Outcomes in Kidney Transplant Patients Randomized to Steroid Avoidance or Maintenance Steroids with Early Intensified Dosing of Enteric-Coated Mycophenolate Sodium: The INFINITY Study

A. Thierry, G. Mourad, M. Büchler, N. Kamar, F. Villemain, A. Heng, Y. Le Meur, G. Choukroun, O. Toupance, C. Legendre, P. Le Pogamp, M. Kessler, P. Merville, B. Moulin, S. Quéré, A. Lécuyer, F. Di Giambattista, G. Touchard
Thrombin Generation and Platelet Activation in a Xenogenic Lung Perfusion Model Determine Survival of GalTKO.hCD46 Transgenic Lungs

L. Burdorf, E. Rybak, T. Zhang, A. Riner, G. Braileanu, X. Cheng, C. Phelps, D. Ayares, A. Azimzadeh, R. Pierson III
Thromboembolic Events Are Increased in Heart and Lung Transplant Recipients Who Received Intra-Operative Recombinant Factor VIIa

K. Schoeppler, J. Lindenfeld, D. Lyu, T. Grazia, J. Crossno, Jr, K. Vandervest, M. Zamora
Thymic Evidence of Clone Deletion in the Mixed Chimerism Mediated Allograft Tolerance

W. Zhang, Y. Wang, Y. Yang, V. Gorantla, M. Solari, X. Zheng
Thymoglobulin (rATG) Induction Improves Survival in Heart Transplant Recipients: A Retrospective Single-Center Study

T. Jarmi, A. Naif, M. Weston
Thymoglobulin Is Associated with a Significant Reduction in De Novo Donor-Specific Antibodies and Antibody Mediated Rejection in Moderately Sensitized Renal Transplant Recipients

M. Mako, D. Hager, B. Muth, D. Kaufman, T. Ellis, A. Djamali
Thymoglobulin Is Safe and Effective as Induction Therapy for Early Steroid Withdrawal in Pediatric Renal Transplantation

J. Kim, A. Watkins, M. Aull, J. Guerrero, S. Kapur
Thymoglobulin Plus Basiliximab vs Basiliximab as Induction Therapy in Deceased Donor Kidney Transplant Recipients Treated with Tacrolimus and Mycophenolate Mofetil: 1-Year Results of a Prospective Clinical Trial

E. Favi, G. Spagnoletti, N. Silvestrini, M. Salerno, J. Pedroso, J. Romagnoli, F. Citterio
Tighter Pretransplant Glycemic Control Is Associated with Reduced Cardiovascular Events after Kidney Transplant in Diabetic Patients at 5 and 10 Year Follow-Up

J. Tong, A. Shields, D. Hanseman, R. Alloway, S. Woodle
TIM-1 Mucin Domain Is Critical in Breg Development, Induction, and Functional Activity

Y. Wang, M. Yeung, T. Ueno, V. Kuchroo, S. Xiao, N. Najafian, Q. Ding, D. Rothstein
TIM-3 Overexpressing T Lymphocytes Prevent Liver Innate Inflammation Response

Y. Liu, H. Ji, Y. Zhang, X. Shen, F. Gao, S. Joung, R. Busuttil, J. Kupiec-Weglinski
Time in the Operating Room Independently Predicts Blood Utilization, Charges, and a Cost Efficient Practice

R. Gilroy, S. Kumer, J. Kindscher, T. Giacoma, E. Charlton, W. Dunn, T. Schmitt
Time on Waiting List for Patients with High MELD Does Not Influence Graft or Patient Survival after Liver Transplantation

N. Parikh, B. Lapin, M. Abecassis, T. Baker
Time to Presentation of Donor Derived Infection

D. Kaul, E. Dominguez, N. Siparsky, C. Wolfe, S. Taranto, S. Covington, E. Blumberg, M. Green
Time-Varying Relationship between Aboriginal Racial Origin and Transplant Outcomes in Australia, The

S. McDonald, P. Clayton, M. Jose
TIMP-1 Deficiency Promotes p53 Pathway and Impairs Hepatocyte Proliferation in Liver Ischemia Reperfusion Injury

S. Duarte, H. Kato, M. Ho, R. Busuttil, A. Coito
Tissue Proteomics Reveals Protein Differences Associated with Allograft Cellular Rejection

M. Talwar, V. Ahmed, T. Srinivas, N. Bhensdadia, B. Alison, J. Alge, S. Self, J. Arthur, M. Janech
TLR2 Signaling in Epithelial Cells Initiates Sterile Tissue Inflammation through Recruitment of NK Cells in Renal Ischemia Reperfusion Injury

H. Cho, B. Kwon, J. Lee, H. Cha, H. Kim, A. Kim, S. Koo, R. Mittler
TNF-alpha -238 G-Allele Predisposes to Severe Bacterial Infection in Patients with End-Stage Liver Disease Enlisted for Liver Transplantation, The

E. de Mare-Bredemeijer, R. Bartáková, S. Franková, D. Roelen, T. Visseren, P. Trunecka, J. Spicák, H. Metselaar, M. Jirsa, J. Kwekkeboom, J. Sperl
To Pay or Not To Pay for a Kidney – What Do Patients Think?

N. Kessaris, M. Lim, A. Vowler, T. Masher, A. Greenberg, P. Thiruchelvam, V. Papalois, E. Kingdon, M. Phanish, N. Mamode, B. Fernando, I. MacPhee, S. Heap
TOL101 Signaling Pathways, a Novel CD3 Independent T Cell Inactivation & Treg Induction Cascade

D. Getts, E. Chastain, R. Terry, S. Brown, J. Thompson, S. Flechner, A. Wiseman, S. Miller
Tolerance Induction by αLFA1 Monotherapy Reveals Organ Specific CD8-Dependent Immune Mechanisms

R. Plenter, T. Grazia, M. Zamora, C. Lim, R. Gill, B. Pietra
Tolerance Induction Changes Lymph Node Structure and Function

A. Baxi, B. Burrell, J. Bromberg
Tolerance of ACE-Inhibitor/ARB Use Post Renal Transplant

J. Von Visger, T. Pesavento, R. Pelletier, A. Diez, U. Nori
Tolerance Related Gene Expression in Urine from Kidney Transplant Recipients

M. Jenkins, M. Runglall, I. Rebollo-Mesa, P. Mobillo, Y. Kamra, E. Nova-Lamperti, S. Norris, GAMBIT Consortium, G. Lord, R. Lechler, M. Hernandez-Fuentes
Tolerance Requires Unique Remodeling of Lymph Node Structure and Stromal Fibers

B. Burrell, J. Bromberg
Tolerogenic Effect of Maternal Microchimerism Is Linked to Semi-Direct Pathway, The

W. Bracamonte-Baran, Y. Zhou, W. Burlingham
Toll Like Receptor Signaling Pathway Activated and Inflammation Amplified in Naked Caspase-3 siRNA Preserved Auto-Transplant Porcine Kidneys

C. Yang, L. Li, Y. Xue, Z. Zhao, T. Zhao, Y. Jia, R. Rong, M. Xu, M. Nicholson, T. Zhu, B. Yang
Toll-Like Receptor 4 Blockade Enhances Islet Engraftment and Induces Indefinite Islet Allograft Survival

T. Berney, L. Giovannoni, V. Lavallard, Y. Muller, S. Lacotte, P. Morel, C. Toso, L. Shang, B. Daubeuf, M. Kosco-Vilbois, D. Bosco
Total Face and Multi-Organ Procurement from a Brain-Dead Donor: Institutional Experience and Proposed Algorithm

P. Brazio, B. Bojovic, M. Christy, J. Garcia, E. Brown, S. Bartlett, R. Barth, E. Rodriguez
Total Plasma Exchange Does Not Improve Allograft Outcome in Deceased Donor Liver Transplant When Performed for Allograft Dysfunction and Positive Cross-Match

D. Harnois, P. Genco, J. Nguyen
Totally Laparoscopic Living Liver Donor Procedurement Including Two Full Left Lobes

B. Samstein, D. Cherqui, P. Elsa, G. Adam, G. James, L. Steve, K. Tomoaki, B. Robert, E. Jean
Transgenic Expression of Human Thrombomodulin in Donor Pigs Reduces the Incidence of Coagulopathies in a Pig to Baboon Cardiac Xenotransplantation Model

M. Mohiuddin, A. Singh, P. Corcoran, C. Mayhew, R. Hoyt, M. Thomas, B. Lewis, T. Clark, M. Eckhaus, K. Reimann, D. Ayares, K. Horvath
Transitions of Care To Reduce Early Readmissions Following Kidney Transplantation

A. Palumbo, J. Park, L. Kelley
Transmission of Coccidioidomycosis through Organ Transplantation

S. Kusne, S. Taranto, S. Convington, D. Kaul, W. Bell, S. Biggins, E. Blumberg, G. DeStefano, E. Dominguez, D. Ennis, T. Gross, M. Klassen-Fischer, C. Kotton, Y. Law, M. Menegus, R. Miller, M. Pavlakis, T. Pruett, D. LaPointe Rudow, P. Ruiz, N. Siparsky, M. Souter, L. Weiss, C. Wolfe, M. Green
Transplant Certification and Quality Assessment: The Effect of Center Data Input Quality

J. Tuttle-Newhall, K. Lentine, D. Axelrod, L. Ware, J. Milton, M. Schnitzler
Transplant Dermatology Is an Essential Part of Transplant Care: Report of First Year Experience

M. Abdelmalek, C. Chung, E. Pritchett, R. Nijhawan, S. Condon, S. Guy, G. Malat, K. Ranganna, A. Doyle
Transplant Dermatology Referrals Result in Unexpected Non-Malignant Diagnoses

M. Abdelmalek, C. Chung, E. Pritchett, R. Nijhawan, G. Malat, S. Guy, A. Doyle
Transplant Glomerulopathy – An Analysis of 96 Cases To Determine the Risk Factors of Allograft Failure

P. Patri, T. Muthukumar, S. Iwasaki, J. Lee, D. Dadhania, C. Hartono, M. Suthanthiran, S. Seshan
Transplant Renal Arterial Inflow Stenosis Defined by Contrast Enhanced MR Angiography and MR Imaging in Early Period after Renal Transplantation: Predisposing Factors and Clinical Outcomes

J. Hwang, S. Park, B. Choi, H. Chun, J. Kim, C. Yang, Y. Kim, I. Moon
Transplantation of CDC High Risk Kidneys: A Low Risk Option for a High Risk Problem

J. Rogers, A. Farney, G. Orlando, A. Reeves-Daniel, A. Palanisamy, U. Farooq, Y. Al-Shraideh, W. Doares, S. Kaczmorski, M. Gautreaux, S. Winfrey, V. Uloko, S. Iskandar, E. Brim, G. Hairston, R. Stratta
Transplantation Outcomes in Treating Primary Hyperoxaluria (PH) in Pittsburgh. Is the Liver Really That Important?

H. Lam, V. Gunabushanam, E. Bakosi, P. Sood, A. Humar, M. Sturdevant
Transplantation Tolerance That Depends on Regulatory T Cells Induced by TGF-beta-Producing Regulatory B Cells

J. Kim, K. Lee, G. Zhao, R. Stott, J. Soohoo, M. Lian, L. Fitzgerald, H. Yeh, S. Deng, J. Markmann
Transplantation Tourism: High Risk for the Recipients

A. El-Agroudy, S. Ghareeb, S. Alarrayed, E. Farid, H. Alhellow, S. Abdulla
Treatment of Chronic Antibody-Mediated Rejection after Kidney Transplantation: Does Rituximab and Intravenous Globulins Improve Graft Survival?

L. Ghouti-Terki, B. Sautenet, C. Barbet, J. Halimi, Y. Lebranchu, C. Magdelaine, C. Baron, M. Büchler, P. Gatault
Treatment of Cryptococcosis in Solid-OrganTransplant Recipients: Relapse Is Rare after Discontinuation of Therapy

J. Baddley, B. Klausing, K. Brizendine, V. Kumar, B. Julian, D. Eckhoff, J. Tallaj, K. Wille, S. Moser, P. Pappas
Treatment of Late Onset De Novo Donor Specific Antibody (DSA)-Mediated Pediatric Kidney Transplant Rejection with Bortezomib

J. Ghata, P. Sindhwani, T. Lewis, M. Turman
Treatment of Renal Transplant Patients with Autologous Bone Marrow Derived Mesenchymal Stromal Cells Downregulates the Donor Specific Mixed Lymphocyte Reaction

M. Reinders, J. de Fijter, H. Roelofs, D. de Vries, F. Claas, P. van Miert, D. Roelen, C. van Kooten, T. Rabelink
Treatment Option in Diabetic End Stage Renal Disease Patients with Potential Living Kidney Donor: PAK vs. SPLK

J. Jung, Y. Kim, Y. Han, Y. Chung, H. Cho, J. Park, D. Han
Treg Express a Unique Pattern of Trafficking Molecules and Differentially Rely on LFA-1 for Migration Compared to Effector T Cells

C. Brinkman, J. Bromberg
Treg Require Th1 and Th2 Transcription Factors To Prolong Islet Allograft Survival

D. Iwami, J. Bromberg
Trends and Utilization of Intestinal Graft Types in Infants and Children ≤ 15 kg

C. Matsumoto, S. Kaufman, R. Girlanda, E. Island, C. Desai, P. Serrano, N. Yazigi, K. Khan, S. Jessica, M. Bessoud, T. Fishbein
Trends in Kidney Transplant Outcomes in Older Adults

M. McAdams-DeMarco, N. James, J. Walston, D. Segev
Trends in Transplant Patient Safety Situation Reporting

A. Doyle, D. Stewart, K. Taylor, J. Davis, P. Camp
Trends in Usage and Outcomes for Expanded Criteria Donor Kidney Transplantation

A. Castleberry, K. Ravindra, D. Vikraman, M. Worni, A. Barbas, B. Englum, M. Ellis, W. Irish, D. Sudan
Triple Non-Steroidal Maintenance Therapy in a Cohort of Kidney Transplanted Children

R. Vilalta, E. Lara, A. Madrid, M. Muñoz, S. Chocron, G. Ariceta
True MELD Score Is Associated with HCC Patient Outcomes after Liver Transplant

M. Gupta, P. Porrett, D. Goldberg, P. Abt, M. Levine
Tuberculosis in Kidney Transplant – 10 Years Experience

L. Viana, M. Cristelli, M. Tavares, M. Dantas, C. Felipe, N. Oliveira, M. Paula, S. Miranda, M. Franco, H. Tedesco, J. Medina- Pestana
Tumor Necrosis Factor Receptor Type 2 Expression on Regulatory T Cells Predicts Acute Kidney Injury after Kidney Transplantation

M. Nguyen, E. Fryml, S. Sahakian, S. Liu, J. Tchervenkov, S. Paraskevas
Tuning the OPTN's KPD Optimization Algorithm To Incentivize Centers To Enter Their "Easy-to-Match" Pairs

D. Stewart, R. Leishman, E. Sleeman, C. Monstello, G. Lunsford, J. Maghirang, T. Sandholm, S. Gentry, R. Formica, J. Friedewald, K. Andreoni
Twice Daily Telaprevir in Combination with Peginterferon Alfa-2a/Ribavirin in HCV Genotype 1 Liver Transplant Recipients: Interim Pharmacokinetics of the REFRESH Study

H. Vargas, Y. Dai, K. Brown, M. Russo, E. Yoshida, R. Fontana, J. Levitsky, R. Rubin, V. Garg, R. Brown
Twice Daily Telaprevir in Combination with Peginterferon Alfa-2a/Ribavirin in HCV Genotype 1 Liver Transplant Recipients: Interim Safety/Efficacy of the REFRESH Study

R. Brown, M. Russo, J. Levitsky, K. Brown, R. Fontana, H. Vargas, E. Yoshida, M. Bsharat, R. Rubin

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