ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Tacrolimus Metabolism Rate Influences the Kidney Function after Liver Transplantation, The

G. Thölking, L. Siats, C. Fortmann, S. Beckebaum, V. Cicinnati, H. Gerth, H. Wolters, C. Anthoni, J. Brockmann, H. Pavenstädt, H. Schmidt, B. Suwelack, I. Kabar

Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Münster, Germany
Department of Transplant Medicine, University Hospital of Münster, Münster, Germany
Department of General Surgery, University Hospital of Münster, Münster, Germany
Department of Visceral Surgery and Transplantation, University Hospital of Zürich, Zürich, Switzerland

Meeting: 2013 American Transplant Congress

Abstract number: D1698

Related Abstracts
  • A Prospective and Randomized Study of Conversion from Tacrolimus to Cyclosporine A to Improve Glucose Metabolism in Patients With New-Onset Diabetes Mellitus After Renal Transplantation
  • Impact of mTOR and Calcineurin Inhibition on Lipid and Glucose Metabolism – 24 Month Assessment in De Novo Liver Transplant Recipients Treated with Everolimus and Tacrolimus

Introduction: The calcineurin inhibitor (CNI) tacrolimus is a very effective immunosuppressive drug after liver transplantation (LTx) but is often associated with an impaired renal function. This study analyses the impact of the tacrolimus metabolism rate on the renal function after LTx.

Methods: 268 patients underwent a LTx between January 2000 and March 2012 and received an initial immunosuppressive therapy with tacrolimus, mycophenolate mofetile and prednisolone. 6 months after LTx, patients were sectioned in two groups of tacrolimus metabolism rate: slow and fast metabolizers. The tacrolimus metabolism rate was expressed as the dose normalized by blood trough concentration (C/D ratio). The renal function was collected 6, 12 and 36 months after LTx using the estimated glomerular filtration rate (eGFR calculated by the Cockcroft-Gault formula).

Results: At the time of LTx there was no significant difference between the eGRF values of fast and slow metabolizers (81.58±40.25 vs. 94.05±57.49, p=0.18). In the course of the following months in the group of fast metabolizers significant lower eGFR values were found [75.64±32.42 vs. 89.10±34.86 (p=0.034) after 6 months, 70.64±33.63 vs. 87.29±35.44 (p=0.028) after 12 months]. There was a lower but not significantly lower eGFR value after 36 months in the group of fast metabolizers (80.09±39.00 vs. 84.70±31.13, p=0.67). Due to an assumed CNI nephrotoxicity 32.5% of fast metabolizers and 15.7% of slow metabolizers were switched from tacrolimus to another immunosuppressive drug during the first three years after LTx (p=0.016). There were no significant differences between complications like loss of liver function (p=0.62) and death (p=0.46) between the two groups.

Conclusion: The tacrolimus metabolism rate has a significant influence on the renal function after LTx. This analysis confirms that the C/D ratio is a suitable and simple clinical tool to define patients at risk of CNI nephrotoxicity.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Thölking G, Siats L, Fortmann C, Beckebaum S, Cicinnati V, Gerth H, Wolters H, Anthoni C, Brockmann J, Pavenstädt H, Schmidt H, Suwelack B, Kabar I. Tacrolimus Metabolism Rate Influences the Kidney Function after Liver Transplantation, The [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/tacrolimus-metabolism-rate-influences-the-kidney-function-after-liver-transplantation-the/. Accessed April 18, 2021.

« Back to 2013 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.