ATC Abstracts

American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Selective Regulatory T Cell Expansion by a Novel IL-2 Mutein Prolongs Skin Transplant Survival in Mice

    T. J. Borges1, O. Effe1, R. B. Gassen1, A. Al Jurdi1, I. T. Lape1, G. J. Babcock2, S. M. Carlson2, J. C. Madsen1, L. V. Riella1

    1Center For Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, 2Visterra, Inc., Waltham, MA

    *Purpose: Long-term immunosuppression predisposes transplant patients to a greater risk of infection, malignancy and kidney toxicity. Hence, alternative methods to regulate the immune system are…
  • 2021 American Transplant Congress

    Impact of SARS-CoV 2 Infection on Graft Function in Kidney Transplant Recipients: An Academic Single Center Experience

    S. Nahi, A. Shetty, S. Tanna, J. Leventhal

    Northwestern University, Chicago, IL

    *Purpose: Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing to their immunosuppressed state and propensity for…
  • 2021 American Transplant Congress

    Creating Efficiency in the Kidney Transplant Listing: Can We Streamline Candidate Ineligibility?

    A. Vijay, N. Langford, K. Atiemo, S. Giusti, M. Killackey, H. Jeon, A. S. Paramesh

    Tulane Abdominal Transplant Institute, New Orleans, LA

    *Purpose: Evaluation of multiple transplant candidate referrals is a resource-intensive process that may delay listing and eventually transplanting appropriate patients. In this study, we sought…
  • 2021 American Transplant Congress

    Inhibition of Fatty Acid Beta-Oxidation Prolongs Heart Allograft Survival

    B. W. Wong, Y. Zhu, H. Dun, L. Ye

    Surgery, Washington University School of Medicine, Saint Louis, MO

    *Purpose: To test the therapeutic efficacy of pharmacological inhibition of fatty acid beta-oxidation (FAO) on acute heart allograft survival.*Methods: We used a heterotopic Balb/c donor…
  • 2021 American Transplant Congress

    Development of a Rat Model of Antibody-Mediated Rejection After Liver Transplantation

    T. Tajima, K. Hata, J. Kusakabe, H. Miyauchi, S. Uemoto

    Dept. of Surgery, Div. of HBP Surgery & Transplantation, Kyoto University Graduate School of Medicine, Kyoto, Japan

    *Purpose: Antibody-mediated rejection (AMR) is a refractory rejection after donor-specific antibody (DSA)-positive or ABO blood-type incompatible liver transplantation (LT), due at least in part to…
  • 2021 American Transplant Congress

    Human Liver-derived Mesenchymal Stromal Cells (MSC) are Superior Inhibitors of Natural Killer Cells Compared to Bone Marrow or Adipose Tissue-derived MSC

    F. Yigitbilek, M. J. Hansen, W. D. Park, M. D. Stegall, T. Taner

    Mayo Clinic, Rochester, MN

    *Purpose: Guided by the liver allografts’ unique tolerogenic microenvironment and the immunoprotective impact on simultaneously transplanted organs, we recently isolated liver mesenchymal stromal cells (L-MSC)…
  • 2021 American Transplant Congress

    Taurodeoxycholic Acid and L-valine Ameliorate Macrophage Driven Alloimmunity in Obese Transplant Recipients

    M. Quante1, J. Iske1, D. Perkins2, M. Alegre3, H. Zhou1, A. Elkhal1, S. G. Tullius1

    1Department of Surgery, Brigham and Women's Hospital, Boston, MA, 2University of Illinois at Chicago, Chicago, IL, 3Department of Medicine, The University of Chicago, Chicago, IL

    *Purpose: Obesity initiates a chronic inflammatory network linked to more frequent perioperative complications and increased acute rejection rates after organ transplantation. Clinically, morbidly obese transplant…
  • 2021 American Transplant Congress

    CD80/PD-L1 Uniquely Regulates CD4 Effector T Cell Migration

    W. Piao1, L. Li1, Y. Zhang2, K. Hippen2, M. WillsonShirkey1, B. Blazar2, L. Riella3, J. Bromberg1

    1U Maryland, baltimore, MD, 2U Minnesota, Minneapolis, MN, 3Harvard U, boston, MA

    *Purpose: CD80 is a costimulatory molecule expressed on antigen presenting cells (APCs) that binds CD28 and CTLA4, stimulating or inhibiting immunity, respectively. CD80 also binds…
  • 2021 American Transplant Congress

    HLA Mismatching and Subclinical Inflammation: An Association to be Considered in Kidney Transplant Patients with Low Immunological Risk

    T. Vazquez-Sanchez1, J. Alonso-Titos1, P. Ruiz-Esteban1, A. Caballero2, M. Leon3, V. Lopez1, E. Sola1, D. Hernández1

    1Nephrology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain, 2Immunology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain, 3Pathology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain

    *Purpose: Subclinical inflammation (SCI) (
  • 2021 American Transplant Congress

    Sampling Renal Biopsies in Pre-Clinical Research for Comprehensive Assessment

    C. M. Edwards1, C. Albert2, D. Stern1, J. Langford1, W. Day2, J. R. DiRito1, W. M. Saltzman2, M. Kashgarian3, J. S. Pober4, G. T. Tietjen1

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale School of Medicine, New Haven, CT, 3Pathology, Yale School of Medicine, New Haven, CT, 4Immunobiology, Yale School of Medicine, New Haven, CT

    *Purpose: Previous literature has demonstrated that single biopsies are not representative of a whole kidney in clinical assessments. In this study we aimed to design…
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