Am J Transplant, Volume 21, Suppl 3 Archives - Page 4 of 139 - ATC Abstracts

2021 American Transplant Congress
Waitlist Outcomes for Patients with Hepatocellular Carcinoma Following the 2019 Exception Policy Change
K. Young¹, C. Enestvedt², W. Naugler¹, E. Maynard², A. Mitra¹, M. Wungiranirun¹, J. Jou¹, J. Ahn¹, M. Chang¹, D. Lhewa¹
¹Division of Gastroenterology and Hepatology, OHSU, Portland, OR, ²Division of Abdominal Organ Transplant, OHSU, Portland, OR
*Purpose: We aim to compare waitlist (WL) outcomes for HCC patients after the implementation of the most recent UNOS exception policy change on 5/1/2019.*Methods: All…
2021 American Transplant Congress
Review of Unos Report of Organ Offers is Supplemented with Documented Real-time Communication Messages
E. S. Pahl¹, N. Patterson²
¹University of Iowa, Iowa City, IA, ²Iowa Methodist, Des Moines, IA
*Purpose: Use real time group messaging data among procurement and transplant professionals to supplement the review of UNOS Report of Organ Offers (ROO) for declined…
2021 American Transplant Congress
Association Between Donor-Recipient Genetic Matching and Acute Rejection in Kidney Transplantation
R. Cao¹, V. Arthur², J. Chen², B. Keating², C. Dorr³, D. Schladt³, G. Onyeaghala³, R. Mannon⁴, A. Matas¹, R. Remmel¹, N. Pankratz¹, B. Wu¹, W. Oetting¹, P. Jacobson¹, A. Israni³, W. Guan¹
¹University of Minnesota, Minneapolis, MN, ²University of Pennsylvania, Philadelphia, PA, ³Hennepin Healthcare Research Institute, Minneapolis, MN, ⁴University of Nebraska, Omaha, NE
*Purpose: In this study we carried out a genome-wide association study (GWAS) between donor-recipient matching scores at individual SNP level and Acute rejection (AR) in…
2021 American Transplant Congress
Properties of Regulatory B Cells Suppressing B Cells
Q. Fu¹, K. Lee², K. Deng², G. Huai², C. Rickert², H. Yang¹, C. LeGuern², S. Deng¹, J. F. Markmann²
¹Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, MGH, Boston, MA
*Purpose: Our previous study showed that TLR-Bregs, regulatory B cells generated in vitro through TLR activation, suppressed naïve B cell proliferation triggered by a mitogen…
2021 American Transplant Congress
Enhancement of Regulatory T Cell Therapies by Biomimetic Nanofiber Matrices on Single Cells
L. A. Fraser¹, S. Lee¹, Y. Sambandam², J. He², X. Huang², D. Z. Ivancic², J. Mathew², Z. J. Zhang², J. R. Leventhal², L. Gallon², S. I. Stupp¹
¹Simpson Querrey Institute, Northwestern, Chicago, IL, ²Surgery – Comprehensive Transplant Center, Northwestern, Chicago, IL
*Purpose: Here we report a new method to create an artificial and biodegradable matrix of biomimetic nanofibers on single cells with the goal of enhancing…
2021 American Transplant Congress
Treg Lymphotoxin Engages Lymphotoxin Receptor on Cancer and Endothelial Cells to Promote Cancer Metastatic Migration: Mechanisms for Treg-Cancer Interactions
W. Piao, R. Oakes, C. Paluskievicz, J. Christopher, J. Bromberg
U Maryland, Baltimore, MD
*Purpose: Treg immune suppression which is critical for transplant graft survival may also enhance tumor growth and metastases. Treg lymphotoxin (LTα1β2) may directly engage the…
2021 American Transplant Congress
IL-10 Signaling in T Cells Modulates Costimulation-independent Activation and is Essential for Transplant Tolerance Induction
M. Iglesias Lozano¹, D. Bibicheff¹, M. Chicco², A. Komin¹, G. Brandacher¹, G. Raimondi¹
¹Plastic Surgery, Johns Hopkins University, Baltimore, MD, ²Frimley Health NHS Foundation Trust, London, United Kingdom
*Purpose: Costimulation blockade (CoB)-based immunotherapy remains a very promising approach for better management of transplant recipients. Understanding the mechanisms that impact the efficacy of CoB…
2021 American Transplant Congress
Selective Bcl-2 Inhibition to Deplete Hematopoietic Stem Cells in Bone Marrow Niche: A Novel Approach to Promote Mixed Chimerism
T. Hirose¹, H. Sasaki¹, G. Lassiter¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, A. Cosimi¹, P. Cippa², T. Fehr², T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Institute of Physiology, University of Zurich, Zurich, Switzerland
*Purpose: A recent murine study has shown that successful mixed chimerism is achievable without myelosuppressive treatments by Bcl-2 inhibition. However, the mechanism by which selective…
2021 American Transplant Congress
Imaging Flow Cytometry Reveals That Platelet-Sized Erythrocyte Fragments are Formed During Pig Organ Perfusion with Human Blood
Z. A. Habibabady¹, F. Ellett², L. Burdorf¹, M. Connolly¹, F. Pollok¹, D. Irimia², R. N. Pierson III¹, A. M. Azimzadeh¹
¹Center for Transplantation Sciences, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA, ²Center for Engineering in Medicine and Surgery, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA
*Purpose: Severe thrombocytopenia frequently occurs after xenotransplantation of porcine cells or organs, and when pig organs are perfused with human blood. We developed a flow…
2021 American Transplant Congress
Augmented Responses of Donor Kidney Tubular Cells to TLR Signaling Correlate with Ameliorated Ischemia/reperfusion Injury and Long-term Allograft Protection
X. Lai¹, J. Wang¹, L. Qiu², S. Han¹, K. Shen¹, Z. Zhang¹
¹Comprehensive Transplant Center, Microsurgery core, Northwestern University, Chicago, IL, ²University of California, San Francisco, San Francisco, CA
*Purpose: We have previously demonstrated that donor genetic background and kidney-intrinsic innate immunity were key determinants of delayed graft function in kidney transplantation. However, the…