Am J Transplant, Volume 21, Suppl 3 Archives - Page 139 of 139 - ATC Abstracts

2021 American Transplant Congress
Reduction in Medication Errors at Discharge in the Transplant Population via Use of Novel Pharmacist / Nursing Dual Check System
M. Norris, S. Witek, C. Whritenour, K. Sigafus, C. Chiang, C. Sammons, D. Naveiro, A. Paredes, E. Perez-Ngai, M. Kaminski, R. Westmoreland, G. Malat
Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Medication errors are of great concern due to the risk for patient and allograft injury. The aim of this study was to evaluate the…
2021 American Transplant Congress
Epigenetic & Functional Changes Associated with Alloreactive Memory CD8 T Cell Subsets in Liver Transplant Patients
H. Abdelsamed¹, S. Liu¹, M. Juya¹, D. Metes², F. Lakkis¹, A. Thomson¹
¹University of Pittsburgh Medical Center, Pittsburgh, PA, ²UPMC, Pittsburgh, PA
*Purpose: Donor-specific allo-reactive memory CD8 T cells play a pivotal role in allo-immunity and represent a major hurdle against tolerance induction in solid organ transplantation.…
2021 American Transplant Congress
Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-mediated Rejection
S. Clotet-Freixas¹, M. Kotlyar², C. M. McEvoy¹, C. Pastrello², S. Rodríguez-Ramírez¹, S. Farkona¹, H. Cardinal³, M. Dieudé³, M. Hébert³, Y. Li¹, O. Famure¹, P. Chen¹, S. Kim¹, E. Chan⁴, I. Jurisica², R. John¹, A. Chruscinski¹, A. Konvalinka¹
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, ⁴Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR) causes >50% of late kidney graft losses. Although donor-specific antibodies (DSA) against HLA cause AMR, antibodies against non-HLA antigens are also…
2021 American Transplant Congress
Ectopic Hepatocyte Transplantation Into the Lymph Nodes in a Fully Mismatched Allogeneic Dog Model Using Tacrolimus and Prednisone
P. A. Fontes
NA, LyGenesis, Pittsburgh, PA
*Purpose: Develop organogenesis through ectopic hepatocyte transplantation (HT) into the upper abdominal lymph nodes (LN).*Methods: Three groups of Mongrel dogs weighting between 25-35 kg (control…
2021 American Transplant Congress
Neutrophil CEACAM1 Induces Hepatic Autophagy and Shapes Innate-adaptive Immune Response in Liver Transplantation: From Mouse-to-human
H. Hirao¹, H. Kojima¹, K. Kadono¹, K. J. Dery¹, K. Nakamura², D. G. Farmer¹, F. M. Kaldas¹, J. W. Kupiec-Weglinski¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, Kyoto University, Kyoto, Japan
*Purpose: Although CEACAM1 (CC1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates innate-adaptive immunity, its role in orthotopic liver transplantation (OLT) remains unknown. CC1 expresses…
2021 American Transplant Congress
Tip60 Inhibitors Enhance Regulatory T Cells (Treg) Induction by Promoting Acetylation of Foxp3
F. Fueyo-Gonzalez¹, G. Vilanova², M. Fribourg¹
¹Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, ²LaCàN, Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain
*Purpose: TIP60, a histone/protein acetyltransferase essential for multiple functions in the cell, is involved in Foxp3 acetylation in Treg. Acetylation protects Foxp3 from degradation, and…
2021 American Transplant Congress
Tissue-Specific Features of Immunity Revealed by Single-cell RNA Sequencing of Healthy Human Kidney
S. Q. Crome¹, J. M. Szusz², C. McEvoy¹, J. An¹, S. Clotet-Freixas¹, S. A. MacParland¹, G. D. Bader³, A. Konvalinka¹
¹Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network and the University of Toronto, Toronto, ON, Canada, ²Immunology, University of Toronto, Toronto, ON, Canada, ³Molecular Genetics, University of Toronto, Toronto, ON, Canada
*Purpose: Tissue-resident immune cells reside within distinct niches across organs, where they sustain tissue homeostasis and rapidly respond to perturbations in the local microenvironment. Across…
2021 American Transplant Congress
Cold Perfusion for Ischemia Minimization Reduces Cardiac Injury in an Ex Vivo Xenoperfusion Model
M. R. Connolly¹, A. Calhoun¹, F. Pollok¹, L. Burdorf¹, Z. Habibabady¹, M. Ma¹, S. Miura¹, W. Eyestone², C. Phelps², D. Ayares²
¹Massachusetts General Hospital, Boston, MA, ²Revivicor, Blacksburg, VA
*Purpose: Prior studies using Steen’s cold perfusion storage technique for heart ischemia minimization (IM) prevented initial xenograft dysfunction (IXD). Our pilot data evaluates the effect…
2021 American Transplant Congress
Hepatic Ferroptosis in Cold Stress and Warm Ischemia-reperfusion: A Novel Therapeutic Target in Liver Transplantation
H. Kojima¹, H. Hirao¹, K. Kadono¹, T. Ito¹, K. J. Dery¹, S. Kageyama², K. Nakamura³, F. M. Kaldas¹, D. G. Farmer¹, J. W. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²Kyoto University, Kyoto, Japan, ³Nishi-Kobe Medical Center, Kyoto, Japan
*Purpose: Ferroptosis, a newly discovered programmed cell death platform, due to iron-dependent accumulation of lipid peroxides, has been reported to aggravate ischemia-reperfusion (IR) injury in…