Am J Transplant, Volume 16, Suppl 3 Archives - Page 173 of 180 - ATC Abstracts

2016 American Transplant Congress
Kidney Graft Homing of De Novo Donor Specific HLA Antibodies Is an Early Step within the Antibody-Mediated Graft Damage Process.
A. Nocera,¹ M. Cioni,² A. Tagliamacco,¹ A. Innocente,³ I. Fontana,⁴ A. Magnasco,² A. Nocco,³ A. Sementa,² G. Garibotto,¹ G. Ghiggeri,² M. Cardillo,³ P. Comoli,⁵ F. Ginevri.²
¹Transplant Immunology and Nephrology, University of Genova, Genova, Italy; ²Nephrology and Pathology, G. Gaslini Institute, Genova, Italy; ³Transplantation Immunology, Fondazione Cà Granda Ospedale Maggiore Policlinico, Milano, Italy; ⁴Kidney Transplant Surgery, IRCCS S.Martino-IST, Genova, Italy; ⁵Pediatric Hematology/Oncology, IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy.
In this study, by a parallel analysis on sera and graft biopsies we have analyzed, in a pediatric cohort of unsensitized recipients of a first…
2016 American Transplant Congress
Treatment of Late Antibody-Mediated Rejection: Observations from Clinical Practice.
G. Einecke,¹ J. Bräsen,² A. Schwarz,¹ H. Haller,¹ F. Njau.¹
¹Nephrology, Medical School of Hannover, Hannover, Germany; ²Pathology, Medical School of Hannover, Hannover, Germany.
Antibody-mediated rejection (AMR) is a major cause of late renal allograft failure. The benefit of treatment of chronic ABMR is unknown. Currently there is no…
2016 American Transplant Congress
Induction with T-cell Depletional Agents Is Safe and Efficacious in the Very Elderly Kidney Transplant Recipients: An Analysis of the OPTN Database.
H. Dave, L. Wolfe, H. Fattah, D. Kumar, A. King, M. Levy, A. Cotterell, A. Sharma, C. Bhati, G. Gupta.
Virginia Commonwealth University, Richmond, VA.
Background: Kidney transplantation is increasingly being offered to the very elderly (Age>70 years) kidney transplant recipients. Previous studies analyzing the effect of induction immunosuppression in…
2016 American Transplant Congress
A Prospective Randomized, Comparative Trial of High-Dose Mizoribine versus Mycophenolate Mofetil in Combination with Tacrolimus and Basiliximab for Living Donor Renal Transplantation: A Multi-Center Trial.
H. Ishida,¹ K. Tanabe,¹ S. Takahara,² N. Amada,³ K. Takahashi,⁴ H. Toma.⁵
¹Urology, Tokyo Women's Medical University Hospital, Tokyo, Japan; ²Advanced Technology for Transplantation, Osaka University, Osaka, Japan; ³Surgery, JCHO Sendai Hospital, Sendai, Japan; ⁴Niigata Organ Transplant Foundation, Niigata, Japan; ⁵Urology, Toda Chuo Hospital, Toda, Saitama, Japan.
PURPOSE: To compare the clinical outcomes of mizoribine (MZR; 12 mg/kg/day) and mycophenolate mofetil (MMF; 2000 mg/day) in combination with tacrolimus (FK), basiliximab (SIM), and…
2016 American Transplant Congress
Will the New Kidney Allocation System Negatively Impact Future Organ Donation in States Mandated to Export a Large Number of Kidneys?
D. Mital,¹ E. Hull,¹ J. Brown,¹ C. Karmell,² M. Jendrisak.²
¹Kidney Transplant Program, General Surgery, Advocate Christ Medical Center, Oak Lawn, IL; ²Quality and Process Improvement, Gift of Hope OPO, Itasca, IL.
Purpose: To examine the potentially deleterious effects of the new Kidney Allocation System (KAS) on future organ donation: as a consequence of the massive increase…
2016 American Transplant Congress
Liver Ischemia Induces Kupffer Cell Necroptosis to Facilitate Liver Inflammatory Immune Activation.
S. Yue,¹ H. Zhou,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsAlthough mechanisms of liver immune activation against ischemia reperfusion injury (IRI) have been studied extensively, cellular bases have yet to be fully defined…
2016 American Transplant Congress
Allograft TLR4 Receptor Signaling Induces Specific Early Inflammatory Events in Promotes Allografts Subjected to Prolonged Cold Ischemic Storage.
T. Yagisawa, N. Kohei, D. Kish, R. Fairchild.
Dept. Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH.
Engagement of Toll-like receptors (TLR) by endogenous danger-associated molecular pattern ligands contributes to the intensity of tissue inflammation, including the inflammation generated during ischemia-reperfusion injury…
2016 American Transplant Congress
Anti-LG3 Antibodies Enhance Renal Microvascular Rarefaction, Fibrosis and Dysfunction Associated with Ischemia-Reperfusion Injury.
B. Yang,^1,3 K. Hamelin,^1,3 M. HÉnault-Rondeau,^1,3 N. Patey,^1,2,3 J. Turgeon,^1,3 S. Lan,^1,3 L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ M. DieudÉ,^1,3 M.-J. HÉbert,^1,3 H. Cardinal.^1,3
¹Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; ²Department of Pathology, CHU Ste-Justine, Montreal, QC, Canada; ³Canadian National Transplant Research Program, CNTRP, Canada.
Delayed graft function (DGF) is associated with decreased kidney graft survival. We have shown that pre-transplant anti-LG3 autoantibodies were associated with increased risk of DGF…
2016 American Transplant Congress
Ineligible: Attitudes and Follow-Up of Individuals Ruled Out of Living Kidney Donation.
D. Dobosz,¹ C. Thiessen,¹ J. Gannon,¹ S. Li,¹ K. Kennedy,² D. Gray,³ A. Mussell,³ E. Gordon,² S. Kulkarni,¹ P. Reese.³
¹Yale U, New Haven; ²Northwestern U, Chicago; ³U Pennsylvania, Philadelphia.
Background: Little is known about the experiences of individuals who begin living kidney donor (LKD) evaluation but are turned down due to ineligibility. We assessed…
2016 American Transplant Congress
Effect of Baseline Proteinuria on Long- and Short-Term Outcomes in Live Kidney Donors – 10 Year U.K Cohort Study.
N. Krishnan,¹ L. Bradbury,² N. Raymond.¹
¹Renal & Transplantation, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, United Kingdom; ²Statistics, National Health Service, Organ Donation & Transplant, Bristol, United Kingdom.
Living kidney donation has significantly improved recipient and graft survival world wide. It is importanat to have a better understanding of the outcomes and risks…