2016 American Transplant Congress
DEPTOR Inhibits mTORC1 in CD4+ T Cells and Increases Treg Function by Stabilizing Foxp3 Expression.
The modulation of PI-3K/Akt-induced signaling is critical for CD4+ Treg homeostasis and stability. Moreover, activation of PI-3K/Akt/mTOR signals within T cell subsets is associated with…2016 American Transplant Congress
TGFb in Regulatory B Cells-Dependent Tolerance.
Surgery, Massachusetts General Hospital, Boston, MA.
In transplantation, increasing evidence support that B cells can play a major regulatory role in addition to their critical functions in allo-immunity and graft rejection.…2016 American Transplant Congress
Transfer of Donor-Derived Exosomes to Recipient Ag-Presenting Cells Is Critical for Allograft Recognition.
After organ transplantation, T cells are primed against donor MHC molecules by donor dendritic cells (DCs) mobilized from the graft. Nevertheless, evidence suggests that donor…2016 American Transplant Congress
Successful Treatment of Established Acute Allograft Rejection with Delayed CTLA-4Ig.
Purpose: Our goal was to determine the efficacy and immune mechanisms of costimulation blockade by CTLA-4Ig when treatment begins after an immune response is already…2016 American Transplant Congress
The Impact of Pre-Transplant Infections on Post-Liver Transplant Outcomes.
Background: Pre- and Post-liver transplant infections are a common cause of morbidity and mortality in orthotopic liver transplant (OLT) patients. How pre-transplant infections affect early…2016 American Transplant Congress
Financial Burdens and Coping Mechanisms of Living Kidney Donors.
1Yale U, New Haven; 2Northwestern U, Chicago; 3U Pennsylvania, Philadelphia.
BackgroundFinancial disincentives remain a major barrier to increasing rates of living kidney donation. A recent study found that 96% of living kidney donors (LKD) reported…2016 American Transplant Congress
Efficacy and Renal Function in Kidney Transplant Recipients Receiving Tacrolimus (TAC)-Based Immunosuppressive Regimens in Combination with Everolimus (EVR) versus Mycophenolate (MPA).
Nephrology Division, Hospital do Rim - UNIFESP, Sao Paulo, Brazil.
Acute rejection and renal function are associated with long-term renal allograft survival. We evaluated these outcomes in patients receiving reduced TAC exposure combined with EVR…2016 American Transplant Congress
Induction Therapy with Rabbit Antithymocyte Globulin (rATG, Thymoglobulin®) vs Basiliximab After Kidney Transplantation: A Health Economic Analysis from a German Perspective.
Study objective. A health economic analysis was undertaken to quantify the economic consequences of acute rejection and serious adverse events in patients receiving induction with…2016 American Transplant Congress
The Impact of Body Mass Index > 35 on Kidney Transplant Outcomes: A Systematic Review.
Organ Transplant, University of Illinois Hospital and Health Sciences System, Chicago, IL.
Background: The increased prevalence of obesity (BMI > 30) among adults in the United States over the last two decades is reflected in the number…2016 American Transplant Congress
Microarray Analysis of Transbronchial and Mucosal Biopsies in Lung Transplant Recipients Detects Molecular Changes of T-Cell Mediated Inflammation.
Purpose: The main diagnostic platform for rejection in lung transplant recipients is histology of transbronchial biopsies (TBB), a test with a poor performance and safety…
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