ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Does Rising MELD Score Convey Worse Liver Transplant Outcome?

A. Rahnemai-Azar, J. Perkins, M. Montenovo, T. Pearson, R. Bakthavatsalam, S. Rayhill, A. Dick, J. Reyes, L. Sibulesky.

Surgery, University of Washington, Seattle, WA.

Meeting: 2016 American Transplant Congress

Abstract number: B245

Keywords: Allocation, Liver, Liver transplantation, Outcome

Session Information

Date: Sunday, June 12, 2016

Session Name: Poster Session B: Liver: MELD, Allocation and Donor Issues (DCD/ECD)

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • MELD Score Does Not Predict Outcome of Living Donor Liver Transplantation
  • Outcomes of Living and Deceased Donor Liver Transplant Recipients According to the MELD Score.

Since February 2002, the Model for End-Stage Liver Disease (MELD) score has been used to allocate liver allografts in the U.S. The aim of this study was to investigate if deterioration in a patient's clinical status, reflected by a rising MELD score, has an impact on post-liver transplant outcome. Furthermore, we aimed to determine if a rising MELD score is a better survival predictor than the final MELD score.

The SRTR data of all patients (≥18 years old) that underwent liver transplantation between 3/1/2002 to 12/31/2013 was investigated. Patients with re-transplants, living donor liver transplants, multi-organ transplants, and those who received exception points (e.g. cancer patients) were excluded from analysis. Cox proportion hazard model was used to determine significant variables influencing the transplant mortality rate.

The data on 31,711 transplant recipients with a mean age of 52.3 ± 10.5 years were included. Increase in MELD score ≥ 10 was found to be significant in predicting post-transplant mortality (HR 1.08, CI 1.02- 1.15). In the sickest patients (MELD 33 to 40), this impact was stronger (HR 1.14, CI 1.04- 1.25). Using change in MELD score (between the time of listing and time of transplantation) as a continuous variable, for every 1 point increase in MELD score the rate of mortality increased by 0.5% (HR 1.005, CI 1.001 – 1.008). Both the final MELD score and rate of change per month (MELD velocity) as continuous variables were not significant predictors of mortality.

Patients with rising MELD scores ≥ 10 while on the waiting list have worse outcome after liver transplantation. This finding is independent of their final MELD score. The results of this study reveal that allocating donor allografts in patients with MELD scores 33 to 40 with more stable MELD scores (alteration in MELD score < 10 while in waiting list) incur a better outcome. Prospective cohort studies needed to validate our results.

CITATION INFORMATION: Rahnemai-Azar A, Perkins J, Montenovo M, Pearson T, Bakthavatsalam R, Rayhill S, Dick A, Reyes J, Sibulesky L. Does Rising MELD Score Convey Worse Liver Transplant Outcome? Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Rahnemai-Azar A, Perkins J, Montenovo M, Pearson T, Bakthavatsalam R, Rayhill S, Dick A, Reyes J, Sibulesky L. Does Rising MELD Score Convey Worse Liver Transplant Outcome? [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/does-rising-meld-score-convey-worse-liver-transplant-outcome/. Accessed February 26, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
      • Penis Transplantation: First U.S. Experience.
      • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
      • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
      • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
      • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

      Visit Our Partner Sites

      American Transplant Congress (ATC)

      Visit the official site for the American Transplant Congress »

      American Journal of Transplantation

      The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

      American Society of Transplantation (AST)

      An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

      American Society of Transplant Surgeons (ASTS)

      The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

      Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

      Privacy Policy

      loading Cancel
      Post was not sent - check your email addresses!
      Email check failed, please try again
      Sorry, your blog cannot share posts by email.
      This site uses cookies: Find out more.