2016 American Transplant Congress
Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients.
Background:The ability of regulatory T cells (Treg) to prolong allograft survival and promote transplant tolerance in lymphodepleted rodents is well-established. Few studies have addressed the…2016 American Transplant Congress
Cold Storage Stabilization of Gap Junctions Reduces Post Transplant Ischemia Reperfusion Injury.
Purpose: Organ procurement, cold storage and ischemia reperfusion injury (IRI) promote inflammation, which induces endothelial cell (EC) activation and dysfunction post transplantation. EC gap junctions…2016 American Transplant Congress
High-Risk Age Window for Graft Loss in Pediatric Lung and Heart Transplant Recipients.
Johns Hopkins University, Baltimore.
Late adolescence and early adulthood is a high-risk age window for pediatric kidney graft loss, though not for pediatric liver graft loss. It is unknown…2016 American Transplant Congress
The Impact of Ritonavir-Boosted Protease Inhibitors and Non-Depleting Antibody Induction on Outcomes in HIV-Infected Kidney Transplant Recipients.
Mount Sinai Hospital, New York.
Background: One-year rejection rates in HIV-infected kidney transplant recipients range from 15-40%, compared to overall rejection rates of 10% in HIV-negative patients. Protocols for immunosuppression…2016 American Transplant Congress
Evaluation of a Risk-Stratified Induction Immunosuppression Protocol Utilizing Low-Dose Antithymocyte Globulin in Renal Transplantation.
Lower doses of rabbit-derived antithymocyte globulin (rATG) may result in less infection and cost, but may increase the incidence of acute rejection. We compared the…2016 American Transplant Congress
Monitoring of De Novo DSA Post Alemtuzumab Induction in Renal Transplant Recipients: One Year Follow Up.
Nephrology & Hypertension, Stony Brook Medicine, Stony Brook, NY.
IntroductionThe presence of de novo DSA (dnDSA) is associated with antibody mediated rejection and less optimal graft outcomes. The overall incidence of dnDSA post renal…2016 American Transplant Congress
Return on Investment for Financial Assistance for Living Kidney Donors in the United States.
Background: Federal financial support through the National Living Donor Assistance Center (NLDAC) assists potential living donors who have prohibitive out-of-pocket expenses. We calculated the return…2016 American Transplant Congress
Clinical Impact of the Verigene® Blood Culture System on Rapid Diagnosis and Antibiotic Optimization in Bacteremic Solid Organ Transplant (SOT) Recipients.
Background:Bloodstream infections are a major concern in SOT recipients and ineffective antibiotic therapy is strongly associated with poor outcomes. Rapid diagnostic tests (RDT) provide prompt…2016 American Transplant Congress
2B4 Over-Expression Impairs Donor-Reactive CD8+ T Cell Proliferation and Accumulation Following Transplantation.
Emory Transplant Center, Emory University School of Medicine, Atlanta, GA.
T cell function is tightly regulated by a fine balance of coinhibitory signals, including those transduced by 2B4 (SLAMf4, CD244), an immunoglobulin-superfamily member constitutively expressed…2016 American Transplant Congress
Inhibitory FcγRIIB Functionally Inhibits Donor-Reactive CD8+ Memory T Cell Responses Following Transplantation.
Emory Transplant Center, Emory University, Atlanta, GA.
Fc receptors are expressed by many types of immune cells and bind to the constant portion of immunoglobulin to mediate their effector functions. The inhibitory…
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