Date: Sunday, June 12, 2016
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Purpose: The implications of donor and recipient race matching in heart transplantation are not clear. The objective of this communication is to quantify the association between donor to recipient race matching and survival in heart transplantation.
Methods: Data came from the Organ Procurement and Transplantation Network Standard Transplant and Analysis Research file, and included data to December 2014. All patients >18 years old who underwent isolated primary heart transplantation between April 25, 2004 and April 24, 2014 were included. The exposure was donor to recipient race match. The outcome was time to death following transplantation. Patients were censored at the last date they were known to be alive. Missing data were addressed using multiple imputation. The propensity to receive a race-matched organ, based on available covariates, was calculated using logistic regression. A Cox regression model was used to compare the hazard of death for patients who did and did not receive a race-matched organ, adjusted for their propensity to receive a race-matched organ.
Results: There were 17,736 heart transplants for which the donor and recipient races were known. 75% (13350) were men and the median age was 55 years. The most common indications for transplantation were dilated cardiomyopathy in 48% (8,599) and ischemic cardiomyopathy in 41% (7,276). 54% (9,506) received a heart from a race-matched donor and 46% (8,230) received a heart from race-mismatched donor. The median survival time was 10.2 years. There was no difference in the propensity-adjusted hazard of death for white (HR 1.11, 95% CL 0.99, 1.18; p=0.06) black (HR 1.08, 95% CL 0.91, 1.27; p=0.40), or non-white, non-black (HR 0.94, 95% CL 0.75, 1.17; p=0.57) patients who received a race-matched heart compared to those who did not.
Conclusion: Race mismatch between donor and recipient is common in heart transplantation. There appears to be no significant association between use of a race-matched organ and recipient survival.
CITATION INFORMATION: Evans C, Sanchez P, Kon Z, Feller E, Griffith B, Pham S. Donor-Recipient Race Matching Is Not Associated with Recipient Survival Following Heart Transplantation. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Evans C, Sanchez P, Kon Z, Feller E, Griffith B, Pham S. Donor-Recipient Race Matching Is Not Associated with Recipient Survival Following Heart Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/donor-recipient-race-matching-is-not-associated-with-recipient-survival-following-heart-transplantation/. Accessed November 24, 2020.
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