ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Impact of HLA-DR Compatibility on Efficacy Outcomes and Renal Function in Kidney Transplant Recipients Following Early Switch from Calcineurin Inhibitor to Everolimus: Subanalysis from the ELEVATE Study.

J. Cruzado, H. Holdaas, P. Lopez, J. Aguilar, G. Dong, F. Claas, W. Arns, M. van der Giet, J. de Fijter.

ELEVATE study group, Llobregat Catalunya, Spain.

Meeting: 2016 American Transplant Congress

Abstract number: B104

Keywords: Efficacy, HLA-DR antigens, Kidney transplantation, Renal function

Session Information

Date: Sunday, June 12, 2016

Session Name: Poster Session B: Drug Minimization

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • Impact of Early Calcineurin Inhibitor Withdrawal on Renal Function and Urinary Protein Excretion: 24 Month Analyses of the ELEVATE Study.
  • Influence of Lipid Levels on Cardiovascular Events After Early Conversion from Calcineurin Inhibitor to Everolimus: 24 M Analysis of the ELEVATE Study.

Background: Human leukocyte antigen (HLA) compatibility between donor and recipient is considered an important factor for graft outcomes. Compatibility is associated with a lower incidence of rejection and improved graft survival. The ELEVATE study was designed to evaluate the impact of early conversion from calcineurin inhibitor (CNI) to everolimus (EVR) after kidney transplant (KTx). Here, we present the 24-month (M) data on the impact of HLA mismatch on graft outcomes and renal function.

Methods: ELEVATE (NCT01114529) is a 24M, multicenter, open-label study, in which de novo KTx recipients (KTxRs, N=717) were randomized at 10-14 weeks post-KTx to EVR (n=360; C0:6–10 ng/mL) or to continue standard CNI regimen (n=357; tacrolimus [TAC] C0: 5–10 ng/mL; cyclosporine [CsA] C0: 100–250 ng/mL); all received EC-MPS + steroids. Treated biopsy-proven acute rejection [tBPAR], antibody mediated rejection (AMR) and graft loss at M24 post-Tx were assessed. Rejection episode were included only if diagnosed after conversion. Renal function was assessed as estimated glomerular filtration rate (eGFR, MDRD4).

Results: Patients with no HLA-DR mismatch showed a comparable incidence of tBPAR between EVR and CNI arms. A trend of increasing incidence of tBPAR was noted with higher mismatches in the EVR arm. A comparable incidence of AMR was noted between arms, however it was significantly higher with 2 mismatches in EVR vs CNI (P=0.013). The incidence of graft loss was similar across arms. Overall, eGFR was better in EVR vs CNI arms. The incidence of AEs was comparable between arms, though AE/infections leading to discontinuation were higher in EVR arm [Table].

Conclusion: The findings of current study, though limited by small sample size, suggest that HLA-DR matching may influence graft outcomes. An increase in the incidence of tBPAR was observed in the EVR arm with increasing HLA-DR mismatch. HLA-DR mismatch did not alter eGFR compared to HLA-DR match, however, better renal function was observed within the EVR arm vs CNI arm.

CITATION INFORMATION: Cruzado J, Holdaas H, Lopez P, Aguilar J, Dong G, Claas F, Arns W, van der Giet M, de Fijter J. Impact of HLA-DR Compatibility on Efficacy Outcomes and Renal Function in Kidney Transplant Recipients Following Early Switch from Calcineurin Inhibitor to Everolimus: Subanalysis from the ELEVATE Study. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Cruzado J, Holdaas H, Lopez P, Aguilar J, Dong G, Claas F, Arns W, Giet Mvander, Fijter Jde. Impact of HLA-DR Compatibility on Efficacy Outcomes and Renal Function in Kidney Transplant Recipients Following Early Switch from Calcineurin Inhibitor to Everolimus: Subanalysis from the ELEVATE Study. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-hla-dr-compatibility-on-efficacy-outcomes-and-renal-function-in-kidney-transplant-recipients-following-early-switch-from-calcineurin-inhibitor-to-everolimus-subanalysis-from-the-elevate-stu/. Accessed March 8, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.