2016 American Transplant Congress
Polyfunctionality of CD8 T Cell Responses to Cytomegalovirus in Transplant Patients.
Background: Cytomegalovirus (CMV) infection causes significant morbidity including allograft damage in transplant patients. Primary infection with CMV is rapidly resolved in healthy individuals; memory T…2016 American Transplant Congress
Donor Sharpin Expression Modulates TNFα Mediated Inflammation and Cardiac Allograft Rejection in Mice.
Increased systemic TNFα levels correlate with transplant rejection and severity of GVHD, and TNFα blockade can prolong graft survival and reduce severity of GVHD. These…2016 American Transplant Congress
Monocytic TNF-α Response to EBV Peptides as a Mean to Identify Over-Immunosuppressed Kidney Transplant Recipients.
Background. The reduction in acute rejection rates seen with the current triple immunosuppressive maintenance regimen has come at the expense of an increased risk of…2016 American Transplant Congress
Mechanism of FK506 Induced TNF Related Apoptosis in Jurkat T Cells.
Department of Surgery, Chonnam National University Hospital, Gwangju, Korea.
Purpose: To elucidate the mechanism of FK506 induced TRAIL(TNF related apoptosis inducing ligand) –R1(DR4) and TRAIL-R2(DR5) in FK506-treated Jurkat T cells. And signal transduction pathway…2015 American Transplant Congress
Enhanced Requirement for TNF Signaling on Low Affinity Memory CD8+ T Cells During Heterologous Immunity
Heterologous immunity, defined as a process during which microbe-specific T cells cross-react with allogeneic antigen and mediate graft rejection, is recognized as a significant barrier…2015 American Transplant Congress
Persistent Expansion of DX5- Memory NK Cells in the Liver After Intraportal Islet Transplantation
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Introduction: We have previously demonstrated that liver NK cells play a pivotal role in islet graft loss during the early phase after intraportal islet transplantation…2015 American Transplant Congress
Mesenchymal Stem Cells Suppress Cytotoxicity of Activated Natural Killer Cells in Liver Via the TRAIL-TRAIL Receptor Pathway in Islet Transplantation
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Introduction: Innate immune reactions against islet grafts are considered a major obstacle for intraportal islet transplantation. We have previously reported that liver natural killer (NK)…2015 American Transplant Congress
Etanercept for Graft Versus Host Disease Following Liver Transplantation
Purpose: Graft versus host disease (GVHD) is a devastating diagnosis and treatment options, such as antithymocyte globulin (ATG), have poor response rates. With a goal…
American Transplant Congress abstracts