ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Tumor necrosis factor (TNF)"

  • 2020 American Transplant Congress

    Analysis of the Mechanism of Liver-Resident NK Cells Activity via the Aryl Hydrocarbon Receptor

    K. Sato, M. Ohira, Y. Imaoka, H. Ohdan

    Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: Tumor recurrence is the main limitation of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). We previously reported an adoptive immunotherapy approach that…
  • 2020 American Transplant Congress

    Activation of Tacrolimus Induced Cytotoxicity Through Apoptotic Pathways

    S. Chung, S. Choi

    Department of Surgery, Chonnam National University, Gwangju, Korea, Republic of

    *Purpose: To elucidate the mechanism of cytotoxicity in FK506-treated Jurkat T cells, signal transduction pathway of TNF-related events was studied.*Methods: Viability of Jurkat T cells…
  • 2020 American Transplant Congress

    Decreased Anti-Tumor Activity of Liver-Resident NK Cells via IL-33 Associated with Portal Hypertension after Living Donor Liver Transplantation

    Y. Imaoka, M. Ohira, K. Sato, H. Ohdan

    Hiroshima Uni., Hiroshima, Japan

    *Purpose: It has been reported that increasing portal vein pressure after living donor liver transplantation (LDLT) was associated with a poor prognosis, risk factors for…
  • 2019 American Transplant Congress

    Prolonged Cold Ischemic Storage Induces Allograft Necro-Inflammation That Increases Graft Susceptibility to T Cell Mediated Rejection

    N. Chun1, R. Ang1, J. Horwitz1, R. Fairchild2, W. Baldwin III2, A. Ting1, P. S. Heeger1

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2Cleveland Clinic, Cleveland, OH

    *Purpose: Prolonged cold ischemic storage (CIS) of murine cardiac allografts causes complement dependent, CTLA4Ig-resistant rejection that is associated with 48h post-transplant elevations in serum levels…
  • 2019 American Transplant Congress

    Targeting Syk Signaling in Myeloid Cells Protects against Liver Fibrosis and Hepatocarcinogenesis

    A. Torres-Hernandez, W. Wang, G. Miller

    Surgery, NYU School of Medicine, New York, NY

    *Purpose: The purpose of our study was to evaluate the mechanistic role of Spleen Tyrosine Kinase (SYK) signaling on the fibrosis - hepatocarcinogenesis axis and…
  • 2019 American Transplant Congress

    Donor Management in Donation after Brain Death: A Window of Opportunity – Are Pro-Inflammatory Mediators the Target and What is the Effect of Duration of Brain Death?

    K. D. Bera1, J. Tabak2, M. L. Lo Faro1, R. J. Ploeg1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2University of Exeter, Exeter, United Kingdom

    *Purpose: Donation after brain death (BD) is a crucial source of transplanted organs - uncertainty remains how duration of BD contributes to outcomes: This study…
  • 2019 American Transplant Congress

    Phenotypic and Functional Analysis of Non-Activated and Allo-Activated Eomesodermin+ CD8+ T Cells in Humans and Nonhuman Primates

    A. Perez Gutierrez1, A. W. Thomson2, D. M. Metes2, M. B. Ezzelarab2

    1Transplantation Institute, University of Chicago Medicine, Chicago, IL, 2Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA

    *Purpose: The T-box transcription factors Eomesodermin (Eomes) and T-bet play a critical role in differentiation and function of CD8+ memory T cells (Tmem). We have…
  • 2018 American Transplant Congress

    BLyS-/- Rats to Prevent Alloantibody Production

    N. Bath,1 B. Verhoven,1 N. Wilson,1 S. Reese,2 L. Coons,1 S. Panzer,2 A. Djamali,2 R. Redfield.1

    1Surgery, University of Wisconsin, Madison, WI; 2Medicine, University of Wisconsin, Madison, WI.

    Introduction: Antibody mediated rejection (AMR) is a major cause of kidney allograft failure. APRIL (A Proliferation Inducing Ligand) and BLyS (B Lymphocyte Stimulator) are two…
  • 2017 American Transplant Congress

    Necroptotic Cellular Death Modulates TNFα Mediated Inflammation and Cardiac Allograft Rejection in Mice.

    R. Ang, P. Heeger, A. Ting.

    Immunology Institute, Icahn School of Medicine at Mount Sinai, NYC, NY

    While graft injury following cold ischemia reperfusion (IR) can accelerate graft rejection, mechanisms are incompletely understood. Evidence indicates that posttransplant IR injury is associated with…
  • 2017 American Transplant Congress

    Mycophenolic Acid Needs Ca2+ to Exert Its Anti-inflammatory Action via Shedding of Toll-Like Receptor4 and Tumor Necrosis Factor Receptor 1.

    J. Kim,1 W. Yang,1 C. Baek,1 N. Han,2 S.-K. Park.1

    1Division of Nephrology, Department of Internal Medicine, Asan Medical Center, Seoul, Republic of Korea; 2Asan Institute for Life Science, Seoul, Republic of Korea

    Background Mycophenolic acid (MPA) has been used for many years to prevent transplantation rejection. Recently, it has been investigated for its anti-inflammatory effects. MPA can…
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