ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Tumor necrosis factor (TNF)"

  • 2020 American Transplant Congress

    A Two-Step Cell-Based Assay Predicts Immunosuppression-Related Adverse Events in Kidney Transplant Recipients

    F. Bouchard-Boivin, O. Désy, S. Béland, S. De Serres

    Transplantation Unit, Renal Division, Medecine Department, Laval University, Québec, QC, Canada

    *Purpose: No clinical tool is available to dynamically access immunosuppression status, which results in serious, often life-threatening adverse effects of immunosuppressants. We recently validated that…
  • 2020 American Transplant Congress

    A Single Nucleotide Polymorphism of Tweak Predicts Arterio- and Arteriolohyalinosis in Kidney Transplants and is Associated with Allograft Survival

    A. Karolin1, D. Thottan1, J. Zinsli1, S. Rudloff1, U. Huynh-Do1, V. Banz2, T. Berney3, M. Pascual4, T. Müller5, P. d’Amico6, I. Binet7, D. Sidler1

    1Nephrology and Hypertension, University Bern, Bern, Switzerland, 2University Bern, Bern, Switzerland, 3University Hospital Genevia, Genevia, Switzerland, 4University Hospital Lausanne, Lausanne, Switzerland, 5University Hospital Zurich, Zurich, Switzerland, 6Hospital St.Gallen, St.Gallen, Switzerland, 7University Hospital Basel, Basel, Switzerland

    *Purpose: We have recently demonstrated that the TNF superfamily member is critical for the pathogenesis of Calcineurin Inhibitor Toxicity (CNT). CNT is a common side…
  • 2020 American Transplant Congress

    Monitoring Inflammatory Cytokines in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)

    S. Ge1, A. Petrosyan1, M. Chu1, N. Ammerman2, A. Vo2, X. Zhang3, S. C. Jordan2, M. Toyoda1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, 3HLA Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Chronic inflammation and HLA sensitization are burdens for end stage renal disease Pts awaiting for a KTx. IL-6 is a pro-inflammatory cytokine responsible for…
  • 2020 American Transplant Congress

    Analysis of the Mechanism of Liver-Resident NK Cells Activity via the Aryl Hydrocarbon Receptor

    K. Sato, M. Ohira, Y. Imaoka, H. Ohdan

    Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: Tumor recurrence is the main limitation of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). We previously reported an adoptive immunotherapy approach that…
  • 2020 American Transplant Congress

    Activation of Tacrolimus Induced Cytotoxicity Through Apoptotic Pathways

    S. Chung, S. Choi

    Department of Surgery, Chonnam National University, Gwangju, Korea, Republic of

    *Purpose: To elucidate the mechanism of cytotoxicity in FK506-treated Jurkat T cells, signal transduction pathway of TNF-related events was studied.*Methods: Viability of Jurkat T cells…
  • 2020 American Transplant Congress

    Decreased Anti-Tumor Activity of Liver-Resident NK Cells via IL-33 Associated with Portal Hypertension after Living Donor Liver Transplantation

    Y. Imaoka, M. Ohira, K. Sato, H. Ohdan

    Hiroshima Uni., Hiroshima, Japan

    *Purpose: It has been reported that increasing portal vein pressure after living donor liver transplantation (LDLT) was associated with a poor prognosis, risk factors for…
  • 2019 American Transplant Congress

    Donor Management in Donation after Brain Death: A Window of Opportunity – Are Pro-Inflammatory Mediators the Target and What is the Effect of Duration of Brain Death?

    K. D. Bera1, J. Tabak2, M. L. Lo Faro1, R. J. Ploeg1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2University of Exeter, Exeter, United Kingdom

    *Purpose: Donation after brain death (BD) is a crucial source of transplanted organs - uncertainty remains how duration of BD contributes to outcomes: This study…
  • 2019 American Transplant Congress

    Phenotypic and Functional Analysis of Non-Activated and Allo-Activated Eomesodermin+ CD8+ T Cells in Humans and Nonhuman Primates

    A. Perez Gutierrez1, A. W. Thomson2, D. M. Metes2, M. B. Ezzelarab2

    1Transplantation Institute, University of Chicago Medicine, Chicago, IL, 2Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA

    *Purpose: The T-box transcription factors Eomesodermin (Eomes) and T-bet play a critical role in differentiation and function of CD8+ memory T cells (Tmem). We have…
  • 2019 American Transplant Congress

    Prolonged Cold Ischemic Storage Induces Allograft Necro-Inflammation That Increases Graft Susceptibility to T Cell Mediated Rejection

    N. Chun1, R. Ang1, J. Horwitz1, R. Fairchild2, W. Baldwin III2, A. Ting1, P. S. Heeger1

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2Cleveland Clinic, Cleveland, OH

    *Purpose: Prolonged cold ischemic storage (CIS) of murine cardiac allografts causes complement dependent, CTLA4Ig-resistant rejection that is associated with 48h post-transplant elevations in serum levels…
  • 2019 American Transplant Congress

    Targeting Syk Signaling in Myeloid Cells Protects against Liver Fibrosis and Hepatocarcinogenesis

    A. Torres-Hernandez, W. Wang, G. Miller

    Surgery, NYU School of Medicine, New York, NY

    *Purpose: The purpose of our study was to evaluate the mechanistic role of Spleen Tyrosine Kinase (SYK) signaling on the fibrosis - hepatocarcinogenesis axis and…
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