Articles tagged "Tumor necrosis factor (TNF)"

2017 American Transplant Congress
Mitochondrial Permeability Can Regulate Endothelial Cell Necroptosis and Promote Cardiac Allograft Rejection.
I. Gan,^1,2 J. Jiang,¹ D. Lian,¹ A. Jevnikar,^1,3 Z.-X. Zhang.^1,2
¹Matthew Mailing Centre for Translational Transplant Studies, Western University, London, ON, Canada; ²Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada; ³Department of Medicine, Western University, London, ON, Canada
Background: Transplant injury is invariably associated with programmed cell death (PCD) resulting in organ rejection. Many forms of PCD have been described including apoptosis, pyroptosis,…
2017 American Transplant Congress
Histone Methyltransferase EZH2 Was Involved in the Mechanism of let-7e Inhibition of TNF-α Expression.
J. Huang,^1,2,3 Y. Zhang,^1,2,3 Q. Zhang,^1,2,3 L. Gui,^1,2,3 Y. Cai,^1,2,3 X. Deng.^1,2,3
¹Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; ³Institute of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
Inflammatory cytokines, such as TNF-α, play important roles in transplantation and infection. The expression of these inflammatory factors can be regulated by many kinds of…
2017 American Transplant Congress
TNF[part]-I After Kidney Transplantation.
B. Muth, B. Astor, D. Mandelbrot.
Department of Medicine, Division of Nephrology, University of Wisconsin, Madison, WI
Infliximab, adalimumab and etanercept are monoclonal antibodies which inhibit tumor necrosis factor alpha (TNF[part]-I) and are used in the treatment of inflammatory diseases such as…
2017 American Transplant Congress
Safety and Decreased Inflammation of Early Double Cytokine Blockade (IL-1β and TNF-α) Facilitates Engraftment in Islet Allotransplantation.
N. Onaca,¹ M. Takita,² M. Levy,³ B. Naziruddin.¹
¹Simmons Transplant Institute, Baylor University Medical Center, Dallas; ²Baylor Scott and White Research Institute, Dallas; ³Hume Lee Transplant Center, Virginia Commonwealth University, Richmond
Enhanced early islet engraftment offers the potential for improved graft function after islet allotransplantation (IT). Nine patients underwent IT under a fully completed prospective research…
2017 American Transplant Congress
High Eomesodermin Expression Correlates with Potent Human Allo-Reactive CD8⁺ Effector T Cells.
A. Perez-Gutierrez, D. Metes, Y. Ono, A. Thomson, M. Ezzelarab.
Surgery, University of Pittsburgh, Pittsburgh, PA
BackgroundThe transcription factors Eomesodermin (Eomes) and T-bet are thought to play critical roles in CD8+ effector memory T cell development. However, the role of Eomes…
2016 American Transplant Congress
Mechanism of FK506 Induced TNF Related Apoptosis in Jurkat T Cells.
S. Chung, S. Choi.
Department of Surgery, Chonnam National University Hospital, Gwangju, Korea.
Purpose: To elucidate the mechanism of FK506 induced TRAIL(TNF related apoptosis inducing ligand) –R1(DR4) and TRAIL-R2(DR5) in FK506-treated Jurkat T cells. And signal transduction pathway…
2016 American Transplant Congress
Monocytic TNF-α Response to EBV Peptides as a Mean to Identify Over-Immunosuppressed Kidney Transplant Recipients.
P. Vallin,¹ O. Désy,¹ S. Béland,¹ E. Wagner,² S. De Serres.¹
¹Renal Division, Quebec University Health Center, Laval University, Quebec, QC, Canada; ²Immunology and Histocompatibility Laboratory, Quebec University Health Center, Laval University, Quebec, QC, Canada.
Background. The reduction in acute rejection rates seen with the current triple immunosuppressive maintenance regimen has come at the expense of an increased risk of…
2016 American Transplant Congress
Donor Sharpin Expression Modulates TNFα Mediated Inflammation and Cardiac Allograft Rejection in Mice.
R. Ang,¹ P. Heeger,² A. Ting.¹
¹Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, NY; ²Center for Translational Transplant Research, Icahn School of Medicine at Mount Sinai, New York City, NY.
Increased systemic TNFα levels correlate with transplant rejection and severity of GVHD, and TNFα blockade can prolong graft survival and reduce severity of GVHD. These…
2016 American Transplant Congress
Polyfunctionality of CD8 T Cell Responses to Cytomegalovirus in Transplant Patients.
L. Higdon,¹ K. Margulies,² J. Maltzman.^1,3
¹Stanford University, Palo Alto; ²University of Pennsylvania, Philadelphia; ³Veterans Administration Medical Center, Palo Alto.
Background: Cytomegalovirus (CMV) infection causes significant morbidity including allograft damage in transplant patients. Primary infection with CMV is rapidly resolved in healthy individuals; memory T…
2016 American Transplant Congress
The Effect of the Use of a TNF-Alpha Inhibitor in Hypothermic Machine Perfusion on Kidney Function After Transplantation.
P. Diuwe,¹ P. Domagala,¹ R. Kieszek,¹ M. Wszola,¹ M. Serwanska-Swietek,¹ L. Paczek,² M. Durlik,³ A. Chmura,¹ A. Kwiatkowski.¹
¹Department of General Surgery and Transplantology, Medical University of Warsaw, Warsaw, Poland; ²Department of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland; ³Department of Transplantology and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Organ damage associated with processes occurring during the ischaemic period as well as during and after organ reperfusion is an important problem of transplantation medicine.The…