ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Tumor necrosis factor (TNF)"

  • 2017 American Transplant Congress

    TNF[part]-I After Kidney Transplantation.

    B. Muth, B. Astor, D. Mandelbrot.

    Department of Medicine, Division of Nephrology, University of Wisconsin, Madison, WI

    Infliximab, adalimumab and etanercept are monoclonal antibodies which inhibit tumor necrosis factor alpha (TNF[part]-I) and are used in the treatment of inflammatory diseases such as…
  • 2017 American Transplant Congress

    Safety and Decreased Inflammation of Early Double Cytokine Blockade (IL-1β and TNF-α) Facilitates Engraftment in Islet Allotransplantation.

    N. Onaca,1 M. Takita,2 M. Levy,3 B. Naziruddin.1

    1Simmons Transplant Institute, Baylor University Medical Center, Dallas; 2Baylor Scott and White Research Institute, Dallas; 3Hume Lee Transplant Center, Virginia Commonwealth University, Richmond

    Enhanced early islet engraftment offers the potential for improved graft function after islet allotransplantation (IT). Nine patients underwent IT under a fully completed prospective research…
  • 2017 American Transplant Congress

    High Eomesodermin Expression Correlates with Potent Human Allo-Reactive CD8+ Effector T Cells.

    A. Perez-Gutierrez, D. Metes, Y. Ono, A. Thomson, M. Ezzelarab.

    Surgery, University of Pittsburgh, Pittsburgh, PA

    BackgroundThe transcription factors Eomesodermin (Eomes) and T-bet are thought to play critical roles in CD8+ effector memory T cell development. However, the role of Eomes…
  • 2017 American Transplant Congress

    Necroptotic Cellular Death Modulates TNFα Mediated Inflammation and Cardiac Allograft Rejection in Mice.

    R. Ang, P. Heeger, A. Ting.

    Immunology Institute, Icahn School of Medicine at Mount Sinai, NYC, NY

    While graft injury following cold ischemia reperfusion (IR) can accelerate graft rejection, mechanisms are incompletely understood. Evidence indicates that posttransplant IR injury is associated with…
  • 2017 American Transplant Congress

    Mycophenolic Acid Needs Ca2+ to Exert Its Anti-inflammatory Action via Shedding of Toll-Like Receptor4 and Tumor Necrosis Factor Receptor 1.

    J. Kim,1 W. Yang,1 C. Baek,1 N. Han,2 S.-K. Park.1

    1Division of Nephrology, Department of Internal Medicine, Asan Medical Center, Seoul, Republic of Korea; 2Asan Institute for Life Science, Seoul, Republic of Korea

    Background Mycophenolic acid (MPA) has been used for many years to prevent transplantation rejection. Recently, it has been investigated for its anti-inflammatory effects. MPA can…
  • 2016 American Transplant Congress

    Mechanism of FK506 Induced TNF Related Apoptosis in Jurkat T Cells.

    S. Chung, S. Choi.

    Department of Surgery, Chonnam National University Hospital, Gwangju, Korea.

    Purpose: To elucidate the mechanism of FK506 induced TRAIL(TNF related apoptosis inducing ligand) –R1(DR4) and TRAIL-R2(DR5) in FK506-treated Jurkat T cells. And signal transduction pathway…
  • 2016 American Transplant Congress

    Monocytic TNF-α Response to EBV Peptides as a Mean to Identify Over-Immunosuppressed Kidney Transplant Recipients.

    P. Vallin,1 O. Désy,1 S. Béland,1 E. Wagner,2 S. De Serres.1

    1Renal Division, Quebec University Health Center, Laval University, Quebec, QC, Canada; 2Immunology and Histocompatibility Laboratory, Quebec University Health Center, Laval University, Quebec, QC, Canada.

    Background. The reduction in acute rejection rates seen with the current triple immunosuppressive maintenance regimen has come at the expense of an increased risk of…
  • 2016 American Transplant Congress

    Donor Sharpin Expression Modulates TNFα Mediated Inflammation and Cardiac Allograft Rejection in Mice.

    R. Ang,1 P. Heeger,2 A. Ting.1

    1Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, NY; 2Center for Translational Transplant Research, Icahn School of Medicine at Mount Sinai, New York City, NY.

    Increased systemic TNFα levels correlate with transplant rejection and severity of GVHD, and TNFα blockade can prolong graft survival and reduce severity of GVHD. These…
  • 2016 American Transplant Congress

    Polyfunctionality of CD8 T Cell Responses to Cytomegalovirus in Transplant Patients.

    L. Higdon,1 K. Margulies,2 J. Maltzman.1,3

    1Stanford University, Palo Alto; 2University of Pennsylvania, Philadelphia; 3Veterans Administration Medical Center, Palo Alto.

    Background: Cytomegalovirus (CMV) infection causes significant morbidity including allograft damage in transplant patients. Primary infection with CMV is rapidly resolved in healthy individuals; memory T…
  • 2016 American Transplant Congress

    The Effect of the Use of a TNF-Alpha Inhibitor in Hypothermic Machine Perfusion on Kidney Function After Transplantation.

    P. Diuwe,1 P. Domagala,1 R. Kieszek,1 M. Wszola,1 M. Serwanska-Swietek,1 L. Paczek,2 M. Durlik,3 A. Chmura,1 A. Kwiatkowski.1

    1Department of General Surgery and Transplantology, Medical University of Warsaw, Warsaw, Poland; 2Department of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland; 3Department of Transplantology and Nephrology, Medical University of Warsaw, Warsaw, Poland.

    Organ damage associated with processes occurring during the ischaemic period as well as during and after organ reperfusion is an important problem of transplantation medicine.The…
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