ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Tumor necrosis factor (TNF)"

  • 2022 American Transplant Congress

    Results Of The Ctot19 Trial: Infliximab (IFX) Induction Does Not Impact 2-year Outcomes In Deceased Donor Kidney Transplant Recipients

    P. Heeger1, B. Armstrong2, T. Alhamad3, D. Brennan4, J. Bromberg5, S. Bunnapradist6, S. Chandran7, R. Fairchild8, D. Foley9, R. Formica10, I. W. Gibson11, D. Hricik12, K. Kesler2, R. B. Mannon13, M. Menon10, K. Newell14, P. Nickerson11, J. Odim15, E. Poggio8, R. Sung16, R. Shapiro1, K. Tinckam17, F. Vincenti7

    1Mount Sinai, New York, NY, 2Rho, Durham, NC, 3Washington U, Saint Louis, MO, 4Johns Hopkins, Baltimore, MD, 5U Maryland, Baltimore, MD, 6UCLA, Los Angeles, CA, 7UCSF, San Francisco, CA, 8Cleveland Clinic, Cleveland, OH, 9U Wisconsin, Madison, WI, 10Yale, New Haven, CT, 11U Manitoba, Winnipeg, MB, Canada, 12U Hosp Case, Cleveland, OH, 13U Nebraska, Omaha, NE, 14Emory, Atlanta, GA, 15NIAID NIH, Rockville, MD, 16U Michigan, Ann Arbor, MI, 17U Hlth Network, Toronto, ON, Canada

    *Purpose: Ischemia-reperfusion (IR) of a kidney transplant (KTx) up-regulates tumor necrosis factor alpha (TNF) production within the allograft. IR-induced TNF amplifies post-KTx allograft inflammation and…
  • 2022 American Transplant Congress

    Atherosclerosis Reduces Anti-Tumor Activity of Liver-Resident Natural Killer Cells

    K. Imaoka, M. Ohira, K. Sato, Y. Imaoka, R. Nakano, H. Ohdan

    Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

    *Purpose: Abdominal aorta calcification (AAC) is associated with an increased relative risk of coronary events, cerebrovascular events, cardiovascular events, and cardiovascular death. We report that…
  • 2022 American Transplant Congress

    P2X7R Inhibition Impairs In Vitro Training of Macrophages

    H. H. Lancia1, R. Sanchez2, A. G. Lellouch1, C. L. Cetrulo1, J. Ochando3, G. Benichou4

    1Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 4Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Macrophage training and ATP-mediated P2X7R signaling are unrelated key elements of the innate immune response associated with allotransplant rejection. In the present study, we…
  • 2022 American Transplant Congress

    Pretransplant Recipient TNFR2+T Regulatory Cell Frequency Predicts Long-Term Outcomes After Kidney Transplantation

    A. Kouyoumdjian, N. Saberi, S. Negi, J. Tchervenkov, S. Paraskevas

    McGill University Health Centre, Montreal, QC, Canada

    *Purpose: Pre-transplant indices capable of predicting long-term renal allograft function could improve graft allocation strategies. We previously associated pretransplant frequency of Tumor Necrosis Factor Receptor…
  • 2022 American Transplant Congress

    Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial to Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing iκB-α

    Z. Gui1, W. Zijie2, M. Zheng3, M. Gu1, R. Tan3

    1Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China, 2Jiangsu Province Hospital, Nanjing, China, 3Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China

    *Purpose: Chronic allograft dysfunction (CAD) is the major cause of late graft loss in long-term renal transplantation. In our previous study, we found Epithelial-mesenchymal transition…
  • 2021 American Transplant Congress

    Extracellular Matrix Injury of Kidney Allografts in Antibody-mediated Rejection

    S. Clotet Freixas1, C. McEvoy1, I. Batruch2, C. Pastrello3, M. Kotlyar3, J. Van1, M. Arambewela1, A. Boshart1, S. Farkona1, Y. Niu3, Y. Li1, O. Famure1, A. Bozovic4, V. Kulasingam4, P. Chen1, J. S. Kim1, E. Chan5, S. Moshkelgosha1, S. A. Rahman6, J. Das6, T. Martinu1, S. Juvet1, I. Jurisica3, A. Chruscinski1, R. John1, A. Konvalinka1

    1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, 3Krembil Research Institute, University Health Network, Toronto, ON, Canada, 4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, 5Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada, 6Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA

    *Purpose: Antibody-mediated rejection (AMR) accounts for >50% of kidney graft losses. AMR is caused by donor-specific antibodies (DSA) against HLA and non-HLA antigens in glomeruli…
  • 2021 American Transplant Congress

    Exosomal DAMP Proteins Released During Islet Isolation Affects TPIAT Outcomes

    P. Saravanan, J. Kalivarathan, M. Levy, M. Kanak

    Hume Lee Islet Cell Transplantation Lab, Department of Surgery, VCU Health, Richmond, VA

    *Purpose: Isolation of islets cause significant stress that results in the release of immunogenic factors called damage-associated molecular patterns (DAMPs) which can induce inflammatory signaling…
  • 2020 American Transplant Congress

    Monitoring Inflammatory Cytokines in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)

    S. Ge1, A. Petrosyan1, M. Chu1, N. Ammerman2, A. Vo2, X. Zhang3, S. C. Jordan2, M. Toyoda1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, 3HLA Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Chronic inflammation and HLA sensitization are burdens for end stage renal disease Pts awaiting for a KTx. IL-6 is a pro-inflammatory cytokine responsible for…
  • 2020 American Transplant Congress

    Analysis of the Mechanism of Liver-Resident NK Cells Activity via the Aryl Hydrocarbon Receptor

    K. Sato, M. Ohira, Y. Imaoka, H. Ohdan

    Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: Tumor recurrence is the main limitation of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). We previously reported an adoptive immunotherapy approach that…
  • 2020 American Transplant Congress

    Activation of Tacrolimus Induced Cytotoxicity Through Apoptotic Pathways

    S. Chung, S. Choi

    Department of Surgery, Chonnam National University, Gwangju, Korea, Republic of

    *Purpose: To elucidate the mechanism of cytotoxicity in FK506-treated Jurkat T cells, signal transduction pathway of TNF-related events was studied.*Methods: Viability of Jurkat T cells…
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