Articles tagged "T cell activation"

2020 American Transplant Congress
Costimulatory Signal Impacts Car Treg Fate and Function in Transplantation
B. Lamarthée¹, A. Marchal¹, S. Charbonnier¹, T. Blein¹, K. Vogt², M. Titeux¹, N. Pallet³, M. Delville¹, E. Six¹, D. Anglicheau⁴, C. Legendre⁴, B. Sawitzki², J. Taupin⁵, M. Cavazzana¹, I. André¹, J. Zuber¹
¹Inserm U1163, Institut Imagine, Paris, France, ²Department of Immunology, Charité University Hospital, Berlin, Germany, ³Inserm U1147, Centre Universitaire des Saints Pères, Paris, France, ⁴Service de Transplantation Rénale Adulte, Assistance Publique–Hôpitaux de Paris, Hôpital Necker, Paris, France, ⁵Inserm U1160, Centre Hayem, Paris, France
*Purpose: Donor-specific regulatory T-cell (Treg) therapy has emerged as a potent strategy to promote immune tolerance in experimental transplantation. However, a major stumbling block in…
2020 American Transplant Congress
Impact of PD1, PDL1 Gene Polymorphisms on Allo-Immune Responses after Kidney Transplantation
H. Yamane, Y. Tanaka, M. Ohira, H. Tahara, K. Ide, H. Ohdan
Hiroshima University, Hiroshima, Japan
*Purpose: The programmed death (PD)-1/PD-1 ligands (PD-Ls) pathway, a member of the B7/CD28 family, triggers an immune checkpoint resulting in inhibition of T cells. Several…
2020 American Transplant Congress
Pretransplant BKV-IgG Serostatus and BKV-Specific ELISPOT Assays for the Prediction of BKV Infection
H. Bae¹, J. Jang¹, H. Lee², S. Yun¹, E. Oh³
¹Department of Biomedical Science, Graduate School, Catholic University of Korea, Seoul 137-040, Korea, Republic of, ²Department of Laboratory Medicine, Catholic Kwandong University of Korea, Incheon, Korea, Republic of, ³Department of Laboratory Medicine, Catholic University of Korea, Seoul 137-040, Korea, Republic of
*Purpose: BK Polyomavirus (BK) can lead to major infectious complications and damage to the graft in kidney transplantation (KT). We investigated whether pretransplant BK serostatus…
2020 American Transplant Congress
Neuropilin 2 is a Novel Coinhibitory Molecule That Suppresses Alloimmune Responses Following Transplantation
J. Wedel, J. Lee, N. Kochupurakkal, E. Chernov, M. Poreddy, K. Liu, S. Kong, D. Bielenberg, H. Nakayama, D. M. Briscoe
Boston Children's Hospital, Boston, MA
*Purpose: We have previously reported that signaling via the transmembrane receptor neuropilin 2 (NRP2) regulates PI3K/mTOR/Akt activity in several human cell lines. Furthermore, it is…
2020 American Transplant Congress
Th17 Cell Inhibition in a Costimulation Blockade Based Regimen for Vascularized Composite Allotransplantation Using A Non-Human Primate Model
D. P. Moris, A. Atia, M. Rae, M. Song, L. Stempora, F. Leopardi, K. Williams, J. Kwun, W. Parker, A. Cardones, A. D. Kirk, L. C. Cendales
Surgery, Duke, Durham, NC
*Purpose: Vascularized composite allotransplantation (VCA) is challenged by the morbidity of non-specific immunosuppression required to prevent rejection. The use of highly specific biologics has not…
2020 American Transplant Congress
Modulating ITK Signaling Facilitate Allogeneic Skin Engraftment and Clear LCMV Viruses by Regulating IRF-4, JAK STAT and Eomes Expression
M. Mammadli¹, M. Karimi¹, S. Mahmudlu¹, A. August², W. Huang²
¹Microbiology and Immunology, Upstate Medical University, Syracuse, NY, ²Microbiology and Immunology, Cornell University, Ithaca, NY
*Purpose:Solid organ transplantation is a life-saving procedure to treat end-stage organ failure. However, transplantation of organs between genetically distinct individuals results in acute graft rejection…
2020 American Transplant Congress
Can Cxcr3⁺Cd62l^–Cd4⁺ T Cells Serve as Early Warning Sentinels for Subclinical Rejections after Vascularized Composite Allotransplantation (vca)?
M. Kim¹, D. Fisher¹, J. Loo¹, J. Skitzki¹, E. Repasky²
¹Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ²Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY
*Purpose: New microsurgical techniques and powerful immunosuppressive drugs have made it possible for severely injured patients to receive VCA to replace limbs, hands, or faces,…
2020 American Transplant Congress
Chronic Kidney Disease Alters the T Cell Response to Murine Cytomegalovirus
R. L. Crepeau¹, H. Li¹, H. S. Koehler², M. L. Ford¹, P. D. Winterberg³
¹Surgery, Emory University, Atlanta, GA, ²Microbiology and Immunology, Emory University, Atlanta, GA, ³Pediatrics, Emory University, Atlanta, GA
*Purpose: We have previously reported that patients with chronic kidney disease (CKD) accumulate memory T cells bearing markers of sustained antigen stimulation and enhanced pro-inflammatory…
2020 American Transplant Congress
Regulatory T Cells Engineered with TCR-Signaling-Responsive Il-2 Nanogels Suppress Alloimmunity in Sites of Antigen Encounter
S. K. Eskandari¹, J. B. Alhaddad¹, I. Sulkaj², M. B. Melo², N. Li², H. Allos¹, B. Kollar¹, M. A. Seelen³, D. J. Irvine⁴, J. Azzi¹
¹Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Koch Institute for Integrative Cancer Research, Massachusetts Insitute of Technology, Cambridge, MA, ³Nephrology, University Medical Center Groningen, Groningen, Netherlands, ⁴Medicine, Koch Institute for Integrative Cancer Research, Massachusetts Insitute of Technology, Cambridge, MA
*Purpose:
2020 American Transplant Congress
B Cell Depletion with Anti-CD20 mAb Exacerbates Anti-Donor CD4⁺T Cell Responses in Highly Sensitized Transplant Model
A. Tanaka, K. Ide, Y. Tanaka, M. Ohira, H. Tahara, H. Morimoto, H. Ohdan
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Preformed donor-specific anti-human leukocyte antigen antibodies (DSAs) have been associated with detrimental effects in transplant recipients. To eliminate preformed DSAs, we desensitized DSA-positive recipients…

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