2020 American Transplant Congress
Peripheral Blood RNA Sequencing Unravels a Differential Role of Coding and Non-Coding Genes by Types of Kidney Allograft Rejection
*Purpose: Peripheral blood molecular patterns characterizing the different effector immune pathways driving kidney allograft rejection remain to be fully completely elucidated, to more fully type…2020 American Transplant Congress
Withaferin A Prolongs Islet Allograft Survival in a Mouse Transplant Model by Preventing T Lymphocyte Proliferation and Dendritic Cell Maturation
*Purpose: Chronic decline in islet graft function and toxicities imposed by immunosuppressant drugs remain as challenges to the widespread use of islet transplantation for type…2020 American Transplant Congress
Autophagy-Lysosome Inhibitor Chloroquine Prevents CTLA-4 Degradation of T Cells and Attenuates Acute Rejection in Murine Skin and Heart Transplantation
*Purpose: The immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), which was induced upon T cell activation but degraded quickly, has been targeted in the clinical…2020 American Transplant Congress
T Cell Hyporesponsiveness in Kidney Transplant Recipients is Associated with Urinary Tract Infections and Age of Kidney Transplant: Implications for Allograft Nephropathy
Dept of Nephrology, University of KwaZulu-Natal, Durban, South Africa
*Purpose: Chronic allograft nephropathy is the main cause of kidney graft loss. With the use of potent immunosuppressive treatments, acute rejections are less and less…2020 American Transplant Congress
Notch Signaling Inhibition via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection
Surgery and Transplantation, Emory University, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…2020 American Transplant Congress
Efficacy of Photobiomodulation Therapy Combined with Short-Term Immunosuppressants Prolonged Allotransplant Survival in a Rodent Hind-Limb Model
*Purpose: Photobiomodulation has been applied for accelerating the skeletal muscle repair process. Our formal study demonstrated vitamin D could be involved in allograft survival and…2020 American Transplant Congress
Mitochondrion-Endothelial Interaction Generates Danger Signal in Promoting Costimulation-Resistant T Cell-Mediated Allograft Rejection
1Surgery, Duke University, Durham, NC, 2Immunology, Duke University, Durham, NC
*Purpose: Endothelial cells (ECs) play a critical role in allorecognition, presentation, and costimulation for initiation of alloimmune rejection. The objective of this study was to…2020 American Transplant Congress
Ischemic and Perfused Kidney Treated with Non-Cultured Adipose-Derived Regenerative Cells Increase the Immune and Regulatory Transcriptome
*Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…2020 American Transplant Congress
Costimulatory Signal Impacts Car Treg Fate and Function in Transplantation
*Purpose: Donor-specific regulatory T-cell (Treg) therapy has emerged as a potent strategy to promote immune tolerance in experimental transplantation. However, a major stumbling block in…2020 American Transplant Congress
Impact of PD1, PDL1 Gene Polymorphisms on Allo-Immune Responses after Kidney Transplantation
Hiroshima University, Hiroshima, Japan
*Purpose: The programmed death (PD)-1/PD-1 ligands (PD-Ls) pathway, a member of the B7/CD28 family, triggers an immune checkpoint resulting in inhibition of T cells. Several…
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