2020 American Transplant Congress
Th17 Cell Inhibition in a Costimulation Blockade Based Regimen for Vascularized Composite Allotransplantation Using A Non-Human Primate Model
*Purpose: Vascularized composite allotransplantation (VCA) is challenged by the morbidity of non-specific immunosuppression required to prevent rejection. The use of highly specific biologics has not…2020 American Transplant Congress
Modulating ITK Signaling Facilitate Allogeneic Skin Engraftment and Clear LCMV Viruses by Regulating IRF-4, JAK STAT and Eomes Expression
*Purpose:Solid organ transplantation is a life-saving procedure to treat end-stage organ failure. However, transplantation of organs between genetically distinct individuals results in acute graft rejection…2020 American Transplant Congress
Can Cxcr3+Cd62l–Cd4+ T Cells Serve as Early Warning Sentinels for Subclinical Rejections after Vascularized Composite Allotransplantation (vca)?
*Purpose: New microsurgical techniques and powerful immunosuppressive drugs have made it possible for severely injured patients to receive VCA to replace limbs, hands, or faces,…2020 American Transplant Congress
Chronic Kidney Disease Alters the T Cell Response to Murine Cytomegalovirus
*Purpose: We have previously reported that patients with chronic kidney disease (CKD) accumulate memory T cells bearing markers of sustained antigen stimulation and enhanced pro-inflammatory…2020 American Transplant Congress
Regulatory T Cells Engineered with TCR-Signaling-Responsive Il-2 Nanogels Suppress Alloimmunity in Sites of Antigen Encounter
*Purpose:2020 American Transplant Congress
B Cell Depletion with Anti-CD20 mAb Exacerbates Anti-Donor CD4+ T Cell Responses in Highly Sensitized Transplant Model
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Preformed donor-specific anti-human leukocyte antigen antibodies (DSAs) have been associated with detrimental effects in transplant recipients. To eliminate preformed DSAs, we desensitized DSA-positive recipients…2020 American Transplant Congress
CD11b is a Novel Alternate Receptor for CD154 During Alloimmunity
*Purpose: For decades, blockade of CD40-CD154 has been shown to be a highly effective means of inhibiting alloreactive T cell responses and inducing long-term graft…2020 American Transplant Congress
Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)
*Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…2020 American Transplant Congress
Interferon-Beta Acts Directly on T Cells to Promote Foxp3 Acetylation in Regulatory T Cells
Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Interferon-β (IFNβ) is a type I interferon that binds to its receptor (IFNAR) expressed on immune cells. It has known antiviral and pro-inflammatory activity…2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…
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