2019 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…2019 American Transplant Congress
Donor-Recipient HLA Mismatched Peptides Calculated by PIRCHE Algorithm Associate with De Novo Donor-Specific Cellular and Humoral Alloreactivity and Predicts Inferior Graft Outcome
*Purpose: PIRCHE-II algorithm predicts mismatched donor-derived HLA peptides number presented on recipient HLAclass-II molecules to recipient T-cells (indirect pathway of allorecognition) and has been associated…2019 American Transplant Congress
Interruption of Notch Signaling via Blockade of Delta-Like Ligands 1 and 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection
Surgery and Transplantation, Emory University, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…2019 American Transplant Congress
Extracorporeal Photopheresis for Specific Immune Tolerance Responses in Heart Transplant Recipients
*Purpose: Extracorporeal photopheresis (ECP) treatment following heart transplantation (HTx) may induce transplant tolerance. A monitoring tool for successful ECP treatment would allow determination of patient-specific…2019 American Transplant Congress
Utilizing Changing Patterns of T-cell Metabolism in Aging for Effective Immunosuppression
Transplant Surgery Research Lab, Brigham and Women’s Hospital, Boston, MA
*Purpose: Metabolic reprogramming has been identified as a critical regulator of immunity. Little is known on changes of T-cell metabolism in aging and how to…2019 American Transplant Congress
Resistance of T Follicular Helper Cells to Depletion by Anti-Thymocyte Globulin
*Purpose: T follicular helper (Tfh) cells are a subset of CD4+ T cells that specializes in providing help for germinal center (GC) reactions where B…2019 American Transplant Congress
Implication of Melanocortin Receptors in Alloimmunity
Transplantation Research Center, Renal, Brigham and Women's Hospital, Boston, MA
*Purpose: Recent studies have indicated the importance of the melanocortin pathway in the regulation of immune responses. In particular, the role that melanocortin receptors (MCRs)…2019 American Transplant Congress
A Regulatory T Cell-Intrinsic Role for Ikaros in Acquired Transplant Tolerance
The Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Ikaros is a transcriptional repressor encoded by the Ikzf1 gene that was recently identified as the pharmacologic target of thalidomide analogs in successful therapy…2019 American Transplant Congress
SIRPα Typing as a Potential Tool for Risk Stratification in Kidney Transplantation
Transplant Immunology Laboratory, Northwestern University, Chicago, IL
*Purpose: To determine if mismatches in the SIRPα receptor, associated with initiate innate alloresponses in animal models, may impact human kidney transplantation outcome.*Methods: To avoid…2019 American Transplant Congress
Evaluating Allo-Specific CD57+ T Cells during Memory and Proliferative Responses
Department of Surgery, Duke University, Durham, NC
*Purpose: We have previously identified subsets of CD57+ T cells that are resistant to B7 costimulation blockade (CoB) in kidney transplant recipients. The objective of…
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