Articles tagged "Renal ischemia"

2019 American Transplant Congress
Histone Deacetylase-2 Knockout in Renal Tubular Cells is Protective in Renal Ischemia-Reperfusion Injury
P. T. Hernandez¹, S. J. Concors¹, L. Krumeich¹, D. D. Aufhauser¹, Z. Wang¹, D. D. Murken¹, G. Ge¹, W. Hancock², M. Levine³
¹General Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, ²Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Transplant Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Ischemia-reperfusion injury (IRI) is a major source of morbidity in renal transplantation and is without targeted therapy. In renal transplantation, IRI contributes to poorer…
2019 American Transplant Congress
Endovascular Repair Of Abdominal Aortic Aneurysms In Kidney Transplant Recipients
S. Kwon¹, D. Jung¹, Y. Kim¹, S. Park², S. Yoon²
¹Department of Vascular and Transplant Surgery, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ²Department of Vascular and Transplant Surgery, The Catholic Universtiy of Korea, Seoul St. Mary's Hospital, Seoul, Korea, Republic of
*Purpose: The possibility to diagnosis abdominal aortic aneurysm (AAA) in patients who underwent kidney transplantation (KT) is increasing. Immunosuppressive agents may effect on AAA progression.…
2019 American Transplant Congress
Human Urine-Derived Stem Cells Protect against Renal Ischemia Reperfusion Injury via Releasing Exosomal miR-146a-5p Which Targets IRAK1 in a Rat Model
X. Li, Z. Bi, Q. Su, H. Huang, L. Liu, C. Wang
Organ Transplant Center, Sun Yat-sen University, Guangzhou, China
*Purpose: Severe ischemia reperfusion injury (IRI) causes delayed graft function and impaires renal allograft survival. Human urine-derived stem cells (hUSCs) is a new source of…
2019 American Transplant Congress
C1 Esterase Inhibitor (C1INH) Treatment at Kidney Transplant Improves Long-Term Outcomes in Patients at Risk for Ischemia/Reperfusion Injury & Delayed Graft Function
S. Jordan¹, E. Huang², N. Ammerman¹, J. Choi¹, O. Aubert³, S. Kumar¹, A. Loupy⁴, A. Peng¹, I. Kim¹, R. Najjar¹, D. Puliyanda¹, T. Brennan¹, S. Sethi¹, A. Vo¹
¹Cedars Sinai Medical Ctr, West Hollywood, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Ctr, West Hollywood, CA, ³Biostatistics Department, Paris Translational Research Center for Organ Transplantation, Paris, France, ⁴Biostatistics, Paris Translational Research Center for Organ Transplantation, Paris, France
*Purpose: Delayed graft function(DGF) is defined as need for dialysis early post-transplant. DGF is related to ischemia reperfusion injury (IRI) that diminishes allograft function and…
2019 American Transplant Congress
Donation After Circulatory Death Kidneys With Prolonged Delayed Graft Function Present Widespread Metabolic And Translational Deficiencies At Time Of Retrieval
M. L. Lo Faro¹, K. Rozenberg¹, H. Huang¹, S. Maslau¹, H. Leuvenink², E. Sharples³, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²University Medical Centre Groningen, Groningen, Netherlands, ³Oxford Transplant Centre, Oxford, United Kingdom
*Purpose: Delayed graft function (DGF) is acute renal failure post-transplant, commonly defined as the need for dialysis in the first week post-transplant. Injury at time…
2019 American Transplant Congress
Effects of Pretreated Bortezomib on Renal Function after Renal Ischemia – Reperfusion Injury in Mice
X. Zheng
Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: To observe the effects of pretreated bortezomib at different points on renal function and renal histology after renal ischemia-reperfusion injury in mice.*Methods: A mice…
2019 American Transplant Congress
Ex Vivo Normothermic Perfusion Of Discarded Human Kidneys Reveals Cold-storage-induced Renal Fibrinogen And Provides A Platform For Therapeutic Repair
J. DiRito¹, S. A. Hosgood², M. Reschke³, M. L. Nicholson², G. T. Tietjen⁴
¹Surgery, Yale University & University of Cambridge, New Haven, CT, ²Surgery, University of Cambridge, Cambridge, United Kingdom, ³Biomedical Engineering, Yale University, New Haven, CT, ⁴Surgery - Transplantation, Yale University, New Haven, CT
*Purpose: The purpose of this study was to: 1) determine the cause of microvascular obstructions that arise during ex vivo normothermic perfusion (NMP) of human…
2019 American Transplant Congress
Ischemic Preconditioning Attenuates Renal Ischemia-Reperfusion Injury through Activating the Nrf2/HO-1 Pathway Enhanced Autophagy
H. Choi¹, Y. Kim², M. Kim², K. Jun², S. Kim², S. Park³, J. Kim⁴, I. Moon⁵, J. Hwang⁶
¹Clinical Research Center, Daejeon St. Mary's Hospital, Daejeon, Korea, Republic of, ²Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ³Transplant Surgery, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ⁴Transplant Surgery, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea, Republic of, ⁵Transplant Surgery, Yeouido St. Mary's Hospital, Seoul, Korea, Republic of, ⁶Transplant Surgery, Daejeon St. Mary's Hospital, Daejeon, Korea, Republic of
*Purpose: Ischemic preconditioning (IPC), which is a brief and nonlethal episode of ischemia, confers protection against subsequent ischemia-reperfusion (I/R) through the up-regulation of endogenous protective…
2019 American Transplant Congress
Randomized Controlled Trial Of Spironolactone Effect In Kidney Transplant Recipients Of Living Donors
N. A. Bobadilla¹, L. E. Morales-Buenrostro¹, J. A. Ortega-Trejo¹, R. Perez-Villalva¹, L. Marino¹, Y. González-Bobadilla¹, H. Juarez¹, F. Zamora-Mejía¹, N. Gonzalez¹, R. Espinoza², J. Barrera-Chimal³
¹Nephrology, INCMNSZ, Mexico City, Mexico, ²Nephrology, Centro Médico Nacional Siglo XXI, Mexico City, Mexico, ³Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico
*Purpose: Mineralocorticoid receptor antagonism prevents acute kidney injury induced by ischemia/reperfusion in rodent and pig preclinical models. In a pilot study, we showed that spironolactone…
2019 American Transplant Congress
Reverse Signaling through CD137 Ligand Promotes Tissue Repair after Ischemia-Reperfusion Kidney Injury
H. R. Cho¹, S. Lee², J. S. Lee³, S. J. Park¹, B. Kwon²
¹Ulsan University Hospital, Ulsan, Korea, Republic of, ²Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, ³Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of
*Purpose: We previously showed that CD137 ligand (CD137L) reverse signaling play a central role in kidney ischemia-reperfusion injury (IRI) by amplifying acute renal injury. In…

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