2022 American Transplant Congress
Artificial Mitochondria Transfer to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation
*Purpose: We aimed at assessing whether artificial mitochondrial transfer (AMT) mitigates renal injury in an in vitro model of tubular damage and in an ex…2022 American Transplant Congress
Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models and can mitigate transplant rejection or injury following ischemic reperfusion…2022 American Transplant Congress
Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts
*Purpose: We have previously demonstrated that donor kidney-intrinsic innate immunity determines the severity of delayed graft function (DGF) in kidney transplantation and potentiates long kidney…2022 American Transplant Congress
Modification of Gut Microbiota Accelerates Kidney Repair After Experimental Ischemia Reperfusion Injury
Johns Hopkins Medicine, Baltimore, MD
*Purpose: Kidney ischemia reperfusion injury (IRI) leads to changes in gut microbiome, and pre-IR microbiome changes can modify course of experimental tissue injury. There is…2022 American Transplant Congress
QSant, a Novel Urine Test Monitors Recovery of Allograft Injury After DGF
1Nephrosant, Brisbane, CA, 2Hospital do Rim, Sao Paolo, Brazil
*Purpose: We evaluate urine QSant assay to non-invasively monitor recovery of allograft injury, post delayed graft function(DGF).*Methods: 65 HLA-DR matched, renal allograft recipients, on TAC/MMF/prednisone…2022 American Transplant Congress
Apoptotic Exosome-Like Vesicles Aggravate Inflammation and Renal Injury After Ischemia-Reperfusion
*Purpose: Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and chronic kidney disease (CKD). Damage to microvascular peritubular capillaries (PTC) is…2022 American Transplant Congress
Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis
Duke University School of Medicine, Durham, NC
*Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…2022 American Transplant Congress
The Role of HNF4α in Renal Ischemia Reperfusion Injury
Toronto General Hospital Research Institute, Toronto, ON, Canada
*Purpose: Ischemia reperfusion injury (IRI) affects all solid organ transplants and impairs renal graft function. However, the mechanisms by which IRI affects grafts are incompletely…2022 American Transplant Congress
Estrogen Receptor Beta Deletion is Protective in Renal Ischemia Reperfusion Injury but Pharmacologic Inhibition of Estrogen Receptor Beta is Not
*Purpose: Renal Ischemia Reperfusion Injury (IRI) contributes substantially to delayed graft function (DGF) in kidney transplantation. Prior work by our group has shown lower rates…2022 American Transplant Congress
Implications of Accumulated Cold Time for US Kidney Transplantation Offer Acceptance
*Purpose: Reducing discard is a current focus in US transplantation of deceased donor kidneys. One cause for the discards is the avoidance of protracted cold…
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