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Articles tagged "Renal ischemia"

  • 2022 American Transplant Congress

    Abnormal Kidney T Cell Metabolism During Ischemia Reperfusion Injury Can Be Modified to Improve Organ Structure and Function

    K. Lee, E. A. Thompson, C. H. Patel, S. Gharaie, J. T. Kurzhagen, S. Noel, P. M. Pierorazio, B. S. Slusher, H. Rabb

    Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: T cells play an important role in the pathophysiology of kidney ischemia reperfusion injury (IRI). Metabolic programming of T cells, a rapidly evolving field,…
  • 2022 American Transplant Congress

    Novel Immune Checkpoint Molecule TIGIT Mediates Experimental Kidney Ischemia Reperfusion Injury

    S. Noel, K. Lee, S. Gharaie, J. T. Kurzhagen, H. Rabb

    Medicine, Johns Hopkins University, Baltimore, MD

    *Purpose: T cells play both pathogenic and reparative roles in kidney ischemia reperfusion injury (IRI) but the molecular mechanisms regulating kidney T cell functions are…
  • 2022 American Transplant Congress

    Evolution of Donor-Derived Cell-Free DNA During the First Week After Surgery Predicts Renal Function Recovery After Kidney Transplantation

    D. Cucchiari1, E. Cuadrado1, E. Gonzalez1, J. Puig1, M. Ramirez-Bajo1, P. Ventura-Aguiar1, I. Revuelta2, B. Bayès1, F. Diekmann1

    1Hospital Clínic de Barcelona, Barcelona, Spain, 2Hospital Clinic de Barcelona, Barcelona, Spain

    *Purpose: Donor-derived cell-free DNA (ddcfDNA) is usually employed starting from the second week after kidney transplantation (KT), as its earlier increase can be due to…
  • 2022 American Transplant Congress

    Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury

    V. Gorbacheva, R. Fan, S. Miyairi, W. M. Baldwin, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Immune responses to self antigens develop following organ transplantation. Multiple studies describe correlations between pre-existing or de novo autoimmune responses and poor transplant outcome.…
  • 2022 American Transplant Congress

    Artificial Mitochondria Transfer to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation

    A. Rossi1, S. Sedrakyan2, F. Montali3, C. Aardena4, N. Abraham5, A. Barbas5, L. N. Byers6, C. Palles7, A. Asthana6, J. Robertson4, L. Perin2, R. Senger4, B. Bussolati1, G. Orlando8

    1Un. of Turin, Turin, Italy, 2Children Hospital, Los Angeles, CA, 3Un. of L'Aquila, L'Aquila, Italy, 4VA Tech, Blacksburg, VA, 5Duke, Durham, NC, 6WFIRM, Winston Salem, NC, 7University of Florida, Gainesville, FL, 8Wake Forest Baptist, Winston-Salem, NC

    *Purpose: We aimed at assessing whether artificial mitochondrial transfer (AMT) mitigates renal injury in an in vitro model of tubular damage and in an ex…
  • 2022 American Transplant Congress

    Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies

    L. Gallon1, J. K. Carrow2, J. He1, Y. Sambandam1, X. Lai1, J. Mathew1, L. C. Palmer2, J. R. Leventhal1, Z. Zhang1, S. I. Stupp2

    1Surgery - Transplant, Northwestern University, Chicago, IL, 2Simpson Querrey Institute, Northwestern University, Chicago, IL

    *Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models and can mitigate transplant rejection or injury following ischemic reperfusion…
  • 2022 American Transplant Congress

    Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts

    X. Lai1, J. Wang1, S. Han1, C. Chunlei1, L. VanOsdol1, L. Gallon2, J. Leventhal2, M. Kandpal1, Z. Zhang1

    1Comprehensive Transplant Center, Microsurgery core, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: We have previously demonstrated that donor kidney-intrinsic innate immunity determines the severity of delayed graft function (DGF) in kidney transplantation and potentiates long kidney…
  • 2022 American Transplant Congress

    Modification of Gut Microbiota Accelerates Kidney Repair After Experimental Ischemia Reperfusion Injury

    S. Gharaie, K. Lee, S. Noel, L. Arend, H. Rabb

    Johns Hopkins Medicine, Baltimore, MD

    *Purpose: Kidney ischemia reperfusion injury (IRI) leads to changes in gut microbiome, and pre-IR microbiome changes can modify course of experimental tissue injury. There is…
  • 2022 American Transplant Congress

    QSant, a Novel Urine Test Monitors Recovery of Allograft Injury After DGF

    S. Ghosh1, H. Tedesco2, R. Sarwal1, N. Titzler1, W. Yazar1, M. Nakamura2, J. Pestana2, M. Sarwal1

    1Nephrosant, Brisbane, CA, 2Hospital do Rim, Sao Paolo, Brazil

    *Purpose: We evaluate urine QSant assay to non-invasively monitor recovery of allograft injury, post delayed graft function(DGF).*Methods: 65 HLA-DR matched, renal allograft recipients, on TAC/MMF/prednisone…
  • 2022 American Transplant Congress

    Apoptotic Exosome-Like Vesicles Aggravate Inflammation and Renal Injury After Ischemia-Reperfusion

    I. Kaci1, S. Lan1, H. Kim1, A. Karakeussian Rimbaud1, F. Migneault1, J. Turgeon1, N. Patey2, M. Dieudé1, M. Hébert1

    1Research Centre, Centre hospitalier de l’Université de Montréal, Montreal, QC, Canada, 2Research Centre, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and chronic kidney disease (CKD). Damage to microvascular peritubular capillaries (PTC) is…
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