Articles tagged "Renal ischemia"

2020 American Transplant Congress
microRNA-223 in MSCS-Derived Exosomes Protects Against Renal Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis Pathway via Directly Targeting NLRP3
C. Ding, W. Xue
Department of Renal Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
*Purpose: miR-223 is a well-studied miRNA that has been tested for abnormal expression in many diseases, and it has been found to play a regulatory…
2020 American Transplant Congress
The Role of Ceria-Nanoparticles in Renal Ischemia Reperfusion Injury Models in Rats
C. T. Chung, H. Ko, H. Kim, H. Mo, A. Han, S. Min, J. Ha
Seoul National University, College of Medicine, Seoul, Korea, Republic of
*Purpose: Preventing ischemia reperfusion injury (IRI) is an important issue in kidney transplantation, significantly related to graft survival. Ceria nanoparticles has antioxidant properties as a…
2019 American Transplant Congress
Donation After Circulatory Death Kidneys With Prolonged Delayed Graft Function Present Widespread Metabolic And Translational Deficiencies At Time Of Retrieval
M. L. Lo Faro¹, K. Rozenberg¹, H. Huang¹, S. Maslau¹, H. Leuvenink², E. Sharples³, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²University Medical Centre Groningen, Groningen, Netherlands, ³Oxford Transplant Centre, Oxford, United Kingdom
*Purpose: Delayed graft function (DGF) is acute renal failure post-transplant, commonly defined as the need for dialysis in the first week post-transplant. Injury at time…
2019 American Transplant Congress
Effects of Pretreated Bortezomib on Renal Function after Renal Ischemia – Reperfusion Injury in Mice
X. Zheng
Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: To observe the effects of pretreated bortezomib at different points on renal function and renal histology after renal ischemia-reperfusion injury in mice.*Methods: A mice…
2019 American Transplant Congress
Ex Vivo Normothermic Perfusion Of Discarded Human Kidneys Reveals Cold-storage-induced Renal Fibrinogen And Provides A Platform For Therapeutic Repair
J. DiRito¹, S. A. Hosgood², M. Reschke³, M. L. Nicholson², G. T. Tietjen⁴
¹Surgery, Yale University & University of Cambridge, New Haven, CT, ²Surgery, University of Cambridge, Cambridge, United Kingdom, ³Biomedical Engineering, Yale University, New Haven, CT, ⁴Surgery - Transplantation, Yale University, New Haven, CT
*Purpose: The purpose of this study was to: 1) determine the cause of microvascular obstructions that arise during ex vivo normothermic perfusion (NMP) of human…
2019 American Transplant Congress
Ischemic Preconditioning Attenuates Renal Ischemia-Reperfusion Injury through Activating the Nrf2/HO-1 Pathway Enhanced Autophagy
H. Choi¹, Y. Kim², M. Kim², K. Jun², S. Kim², S. Park³, J. Kim⁴, I. Moon⁵, J. Hwang⁶
¹Clinical Research Center, Daejeon St. Mary's Hospital, Daejeon, Korea, Republic of, ²Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ³Transplant Surgery, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ⁴Transplant Surgery, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea, Republic of, ⁵Transplant Surgery, Yeouido St. Mary's Hospital, Seoul, Korea, Republic of, ⁶Transplant Surgery, Daejeon St. Mary's Hospital, Daejeon, Korea, Republic of
*Purpose: Ischemic preconditioning (IPC), which is a brief and nonlethal episode of ischemia, confers protection against subsequent ischemia-reperfusion (I/R) through the up-regulation of endogenous protective…
2019 American Transplant Congress
Randomized Controlled Trial Of Spironolactone Effect In Kidney Transplant Recipients Of Living Donors
N. A. Bobadilla¹, L. E. Morales-Buenrostro¹, J. A. Ortega-Trejo¹, R. Perez-Villalva¹, L. Marino¹, Y. González-Bobadilla¹, H. Juarez¹, F. Zamora-Mejía¹, N. Gonzalez¹, R. Espinoza², J. Barrera-Chimal³
¹Nephrology, INCMNSZ, Mexico City, Mexico, ²Nephrology, Centro Médico Nacional Siglo XXI, Mexico City, Mexico, ³Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico
*Purpose: Mineralocorticoid receptor antagonism prevents acute kidney injury induced by ischemia/reperfusion in rodent and pig preclinical models. In a pilot study, we showed that spironolactone…
2019 American Transplant Congress
Reverse Signaling through CD137 Ligand Promotes Tissue Repair after Ischemia-Reperfusion Kidney Injury
H. R. Cho¹, S. Lee², J. S. Lee³, S. J. Park¹, B. Kwon²
¹Ulsan University Hospital, Ulsan, Korea, Republic of, ²Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, ³Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of
*Purpose: We previously showed that CD137 ligand (CD137L) reverse signaling play a central role in kidney ischemia-reperfusion injury (IRI) by amplifying acute renal injury. In…
2019 American Transplant Congress
Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury
S. Lan¹, B. Yang¹, M. Dieudé¹, J. Sabo-Vatasescu², A. Karakeussian-Rimbaud², J. Turgeon², S. Qi³, N. Patey⁴, M. Hébert¹
¹Medicine Faculty, CRCHUM, University of Montreal, Montreal, QC, Canada, ²CRCHUM, Montreal, QC, Canada, ³Department of Surgery, CRCHUM, University of Montreal, Montreal, QC, Canada, ⁴Department of Pathology and Cell Biology, CHU Saint-Justine, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…
2019 American Transplant Congress
Determining the Molecular Nature and Role of Cytoglobin in Chronic Allograft Nephropathy
D. Patel¹, T. Divanyan¹, E. Acosta¹, K. Carnes², D. Howard³, F. Jourd’heuil³, D. Jourd’heuil³, R. Lopez-Soler⁴
¹Albany Medical College, Albany, NY, ²Urology, Albany Medical College, Albany, NY, ³Molecular and Cellular Physiology, Albany Medical College, Albany, NY, ⁴Surgery, Section of Transplantation, Albany Medical College, Albany, NY
*Purpose: Although it is usually accepted that the kidney is prone to hypoxic injury, the importance of hypoxia in chronic kidney disease (CKD) as well…

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