Articles tagged "Renal ischemia"

2020 American Transplant Congress
Tissue Specificity and the Role of Lymphocytes in Estrogen-Mediated Protection from Renal Ischemia Reperfusion Injury
P. T. Hernandez, C. S. O'Brien, S. J. Concors, L. N. Krumeich, Z. Wang, G. Ge, W. Hancock, M. H. Levine
Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Renal ischemia reperfusion injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. We previously demonstrated lower rates of DGF…
2020 American Transplant Congress
Hypothermia Attenuates Renal Fibrosis after Renal Ischemia Reperfusion in Mice
D. Choi¹, D. Kim², E. Kim², J. Jeong², J. Kim¹, Y. Ham¹, Y. Chang³, K. Na¹, K. Lee¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Department of Medical Science, Chungnam National University, Daejeon, Korea, Republic of, ³Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of
*Purpose: Recently, acute kidney injury is a important cause of chronic kidney injury, characterized by glomerular sclerosis and tubular fibrosis. Hypothermia attenuates the acute kidney…
2019 American Transplant Congress
Reverse Signaling through CD137 Ligand Promotes Tissue Repair after Ischemia-Reperfusion Kidney Injury
H. R. Cho¹, S. Lee², J. S. Lee³, S. J. Park¹, B. Kwon²
¹Ulsan University Hospital, Ulsan, Korea, Republic of, ²Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, ³Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of
*Purpose: We previously showed that CD137 ligand (CD137L) reverse signaling play a central role in kidney ischemia-reperfusion injury (IRI) by amplifying acute renal injury. In…
2019 American Transplant Congress
Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury
S. Lan¹, B. Yang¹, M. Dieudé¹, J. Sabo-Vatasescu², A. Karakeussian-Rimbaud², J. Turgeon², S. Qi³, N. Patey⁴, M. Hébert¹
¹Medicine Faculty, CRCHUM, University of Montreal, Montreal, QC, Canada, ²CRCHUM, Montreal, QC, Canada, ³Department of Surgery, CRCHUM, University of Montreal, Montreal, QC, Canada, ⁴Department of Pathology and Cell Biology, CHU Saint-Justine, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…
2019 American Transplant Congress
Determining the Molecular Nature and Role of Cytoglobin in Chronic Allograft Nephropathy
D. Patel¹, T. Divanyan¹, E. Acosta¹, K. Carnes², D. Howard³, F. Jourd’heuil³, D. Jourd’heuil³, R. Lopez-Soler⁴
¹Albany Medical College, Albany, NY, ²Urology, Albany Medical College, Albany, NY, ³Molecular and Cellular Physiology, Albany Medical College, Albany, NY, ⁴Surgery, Section of Transplantation, Albany Medical College, Albany, NY
*Purpose: Although it is usually accepted that the kidney is prone to hypoxic injury, the importance of hypoxia in chronic kidney disease (CKD) as well…
2019 American Transplant Congress
Treprostinil Attenuates Renal Ischemia-Reperfusion Injury in Rat
M. Ding¹, E. Tolbert², M. Birkenbach³, C. Chung⁴, R. Gohh⁵, F. Akhlaghi¹, N. Ghonem¹
¹Biomedical and Pharmaceutical Sciences, URI, Kingston, RI, ²Nephrology, Rhode Island Hsopital, Providence, RI, ³Pathology, Rhode Island Hospital, Providence, RI, ⁴Surgery, Rhode Island Hospital, Providence, RI, ⁵Organ Transplantation, Rhode Island Hospital, Brown University, KINGSTON, RI
*Purpose: Kidney transplantation (KTx) is the optimal treatment for end-stage renal diseases. The surgical procedure of KTx inherently requires cold ischemic preservation and warm reperfusion…
2019 American Transplant Congress
Microvascular Rarefaction and Long-Term Graft Dysfunction in Kidney Transplant Recipients with Delayed Graft Function
A. Doreille, S. Larivière-Beaudoin, A. Karakeussian-Rimbaud, M. Hébert, M. Dieudé, N. Patey, H. Cardinal
1Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada
*Purpose: Delayed graft function (DGF), or acute kidney injury in the perioperative period, is associated with decreased kidney graft survival.*Methods: As animal studies suggest that…
2019 American Transplant Congress
Histone Deacetylase-8 (HDAC8) Inhibition is Protective in a Murine Model of Renal Ischemia Reperfusion Injury (IRI)
P. T. Hernandez¹, S. J. Concors¹, D. D. Aufhauser¹, L. Krumeich¹, Z. Wang¹, G. Ge¹, A. Beeler², M. Levine¹, W. Hancock³
¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²Chemistry, Boston University, Boston, MA, ³Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: IRI is a major source of morbidity after renal transplantation, contributing to poor transplant outcomes and decreased graft survival. Histone deacetylases (HDACs) are enzymes…
2019 American Transplant Congress
Racial Differences in Acute Kidney Injury Occurrence among Deceased Kidney Donors
M. Doshi¹, I. Hall², S. Mohan³, C. Liu⁴, H. Philbrook⁴, P. Reese⁵, S. Mansour⁶, F. Weng⁷, E. Akalin⁸, J. Bromberg⁹, M. Harhay¹⁰, T. Muthukumar¹¹, B. Schroeppel¹², P. Singh¹³, C. Parikh⁴
¹University of Michigan, Ann Arbor, MI, ²University of Utah, Salt Lake City, UT, ³Columbia, New York, NY, ⁴Johns Hopkins, Baltimore, MD, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Yale University, New Haven, CT, ⁷St. Barnabas, Livingston, NJ, ⁸Mount Sinai, New York, NY, ⁹University of Maryland, Baltimore, MD, ¹⁰Drexel, Philadelphia, PA, ¹¹Cornell, New York, NY, ¹²University of Ulm, Ulm, Germany, ¹³Jefferson, Philadelphia, PA
*Purpose: Kidneys from African American (AA) deceased donors have lower graft survival than kidneys from white donors, regardless of recipient race. We hypothesized that kidneys…
2019 American Transplant Congress
Inhibition of CXCR3 Expression through Blockade of STAT3 Alpha Signaling Down-Regulate Inflammation of Renal Ischemia-Reperfusion Injury
J. Kim¹, J. Park², K. Yoo², J. Moon¹, J. Jeong¹, C. Lee³, Y. Kim¹, S. Yang⁴
¹Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Dongguk University College of Medicine, Gyeonggi-do, Korea, Republic of, ³Cheju Halla General Hospital, Cheju, Jeju-do, Korea, Republic of, ⁴Kidney Research Institute, Seoul National University, Seoul, Korea, Republic of
*Purpose: Signal transducer and activator of transcription 3 (STAT3) is the main mediator of interleukin 6 (IL-6)-type cytokine signaling. Although it exists in two isoforms:…

« Previous Page
1
…
3
4
5
6
7
…
12
Next Page »