2020 American Transplant Congress
Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury
*Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…2020 American Transplant Congress
Establishment of Spontaneous Tolerance of Kidney Allografts is Dependent on Mitigation of Ischemia-Reperfusion Injury via the BLTA-HVEM Pathway
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…2020 American Transplant Congress
Exosomes Derived from MSC Ameliorate Renal Ischemic-Reperfusion Injury Through Inhibiting Inflammation and Cell Apoptosis
*Purpose: Investigate the underlying mechanism of mesenchymal stem cells (MSCs) on protection of renal ischemia reperfusion injury (IRI) .*Methods: Exosomes originated from MSCs (MSC-ex) were…2020 American Transplant Congress
Estrogen Receptor Beta Deletion in the Vascular Endothelium is Protective in Renal Ischemia Reperfusion Injury
*Purpose: Renal ischemia reperfusion injury (IRI) is a major contributor to early allograft dysfunction (EAD) in kidney transplantation. We previously identified lower rates of EAD…2020 American Transplant Congress
Mesenchymal Stromal Cell Treatment of Kidneys During Normothermic Machine Perfusion is Safe and Feasible with Effective Traceability after Transplantation
*Purpose: Marginal kidneys are increasingly being accepted to decrease waiting time for a transplant. Normothermic machine perfusion (NMP) is a technique that allows delivery of…2020 American Transplant Congress
Mir-124/ire-1α Affects Renal Ischemia/Reperfusion Injury by Regulating Endoplasmic Reticulum Stress in Renal Tubularepithelial Cells
*Purpose: In this study, we investigated the protective functions of miR-124 on renal I/R injury both in vivo and in vitro and explored its underlying…2020 American Transplant Congress
microRNA-223 in MSCS-Derived Exosomes Protects Against Renal Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis Pathway via Directly Targeting NLRP3
*Purpose: miR-223 is a well-studied miRNA that has been tested for abnormal expression in many diseases, and it has been found to play a regulatory…2020 American Transplant Congress
The Role of Ceria-Nanoparticles in Renal Ischemia Reperfusion Injury Models in Rats
Seoul National University, College of Medicine, Seoul, Korea, Republic of
*Purpose: Preventing ischemia reperfusion injury (IRI) is an important issue in kidney transplantation, significantly related to graft survival. Ceria nanoparticles has antioxidant properties as a…2020 American Transplant Congress
Effects of Kidney Transplantation on Cystogenesis in Kidneys Procured from a Deceased Donor with Autosomal Dominant Polycystic Kidney Disease
*Purpose: Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients are not routinely considered as kidney donors for renal transplantation. This is partially due to a concern…2020 American Transplant Congress
Predominant Role of Microvascular Injury and Rarefaction Function as Drivers of Progressive Renal Damage and Fibrosis Post Mild and Severe Acute Ischemia-Reperfusion Injury
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Here, we characterize the different cell deaths in tubular and microvascular compartments…
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