ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Renal ischemia"

  • 2020 American Transplant Congress

    Poly (ADP-Ribose) Polymerase Inhibitor Treatment Attenuated Renal Ischemia-Reperfusion Injury

    H. Jang, K. Lee, J. Jeon, J. Lee, Y. Kim, D. Kim, W. Huh

    Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of

    *Purpose: Robust intrarenal inflammatory responses following ischemia-reperfusion injury (IRI) induce renal injury in ischemic acute kidney injury (AKI). We hypothesized that poly (ADP-Ribose) polymerase (PARP)…
  • 2020 American Transplant Congress

    Modulation of Ischemia Reperfusion Injury in Renal Transplantation Using Selective Estrogen Receptor Modulators

    P. T. Hernandez1, C. S. O'Brien1, S. J. Concors1, L. N. Krumeich1, W. Hancock2, M. H. Levine1

    1Hospital of the University of Pennsylvania, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA

    *Purpose: Renal ischemia reperfusion injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. We previously demonstrated lower rates of DGF…
  • 2019 American Transplant Congress

    Microvascular Rarefaction and Long-Term Graft Dysfunction in Kidney Transplant Recipients with Delayed Graft Function

    A. Doreille, S. Larivière-Beaudoin, A. Karakeussian-Rimbaud, M. Hébert, M. Dieudé, N. Patey, H. Cardinal

    1Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada

    *Purpose: Delayed graft function (DGF), or acute kidney injury in the perioperative period, is associated with decreased kidney graft survival.*Methods: As animal studies suggest that…
  • 2019 American Transplant Congress

    Histone Deacetylase-8 (HDAC8) Inhibition is Protective in a Murine Model of Renal Ischemia Reperfusion Injury (IRI)

    P. T. Hernandez1, S. J. Concors1, D. D. Aufhauser1, L. Krumeich1, Z. Wang1, G. Ge1, A. Beeler2, M. Levine1, W. Hancock3

    1Hospital of the University of Pennsylvania, Philadelphia, PA, 2Chemistry, Boston University, Boston, MA, 3Children's Hospital of Philadelphia, Philadelphia, PA

    *Purpose: IRI is a major source of morbidity after renal transplantation, contributing to poor transplant outcomes and decreased graft survival. Histone deacetylases (HDACs) are enzymes…
  • 2019 American Transplant Congress

    Racial Differences in Acute Kidney Injury Occurrence among Deceased Kidney Donors

    M. Doshi1, I. Hall2, S. Mohan3, C. Liu4, H. Philbrook4, P. Reese5, S. Mansour6, F. Weng7, E. Akalin8, J. Bromberg9, M. Harhay10, T. Muthukumar11, B. Schroeppel12, P. Singh13, C. Parikh4

    1University of Michigan, Ann Arbor, MI, 2University of Utah, Salt Lake City, UT, 3Columbia, New York, NY, 4Johns Hopkins, Baltimore, MD, 5University of Pennsylvania, Philadelphia, PA, 6Yale University, New Haven, CT, 7St. Barnabas, Livingston, NJ, 8Mount Sinai, New York, NY, 9University of Maryland, Baltimore, MD, 10Drexel, Philadelphia, PA, 11Cornell, New York, NY, 12University of Ulm, Ulm, Germany, 13Jefferson, Philadelphia, PA

    *Purpose: Kidneys from African American (AA) deceased donors have lower graft survival than kidneys from white donors, regardless of recipient race. We hypothesized that kidneys…
  • 2019 American Transplant Congress

    Inhibition of CXCR3 Expression through Blockade of STAT3 Alpha Signaling Down-Regulate Inflammation of Renal Ischemia-Reperfusion Injury

    J. Kim1, J. Park2, K. Yoo2, J. Moon1, J. Jeong1, C. Lee3, Y. Kim1, S. Yang4

    1Seoul National University College of Medicine, Seoul, Korea, Republic of, 2Dongguk University College of Medicine, Gyeonggi-do, Korea, Republic of, 3Cheju Halla General Hospital, Cheju, Jeju-do, Korea, Republic of, 4Kidney Research Institute, Seoul National University, Seoul, Korea, Republic of

    *Purpose: Signal transducer and activator of transcription 3 (STAT3) is the main mediator of interleukin 6 (IL-6)-type cytokine signaling. Although it exists in two isoforms:…
  • 2019 American Transplant Congress

    CD4 T Cell-Derived NGAL Mediates Experimental Acute Kidney Injury

    S. Lee, S. Noel, J. Kurzhagen, M. Sadasivam, A. Hamad, H. Rabb

    Johns Hopkins, Baltimore, MD

    *Purpose: Neutrophil gelatinase-associated lipocalin (NGAL) is a potential biomarker for early detection of acute kidney injury (AKI) in human, but the mechanistic role for NGAL…
  • 2019 American Transplant Congress

    Deficiency of IRE1a Ameliorates Renal Allograft Injury via Remodeling of Graft-Infiltrating Macrophages

    L. Qiu1, J. Wang1, X. Yeap1, S. Han1, F. Zheng1, D. Fang2, Z. J. Zhang1

    1Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, 2Department of Pathology, Northwestern University, Chicago, IL

    *Purpose: Inflammatory macrophages contribute to the development of ischemia-reperfusion injury (IRI) and allograft rejection. However, the underlying mechanisms by which macrophage mediate allograft injury and…
  • 2019 American Transplant Congress

    Anti CD45RB Antibody Therapy Attenuates Renal Ischemia Reperfusion Injury by Inducing Regulatory B Cells

    S. Lee1, S. Park1, J. Hwang1, J. Ryu2, T. Koo2, C. Ahn2, J. Yang3

    1Biomedical Research Institute, Transplantation Center, Seoul National University Hospital, Seoul, Korea, Republic of, 2Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, 3Department of surgery, Seoul National University Hospital, Seoul, Korea, Republic of

    *Purpose: Regulatory B cells (Bregs) are a new B cell subset that suppresses immune responses. Recently, both anti-CD45RB and anti-Tim-1 treatments have been found to…
  • 2019 American Transplant Congress

    Analysis of Lactic Acid Response in Renal Transplant Patients

    A. A. Henderson1, H. Ahmed2, M. R. Wakefield1

    1Surgery/Urology, University of Missouri School of Medicine, Columbia, MO, 2University of Missouri School of Medicine, Columbia, MO

    *Purpose: Lactic acid (LA) serves as an important biomarker in the evaluation of ischemia, sepsis, metabolic acidosis, and trauma. During renal transplantation (RT), there is…
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