Articles tagged "Renal ischemia"

2019 American Transplant Congress
Treprostinil Attenuates Renal Ischemia-Reperfusion Injury in Rat
M. Ding¹, E. Tolbert², M. Birkenbach³, C. Chung⁴, R. Gohh⁵, F. Akhlaghi¹, N. Ghonem¹
¹Biomedical and Pharmaceutical Sciences, URI, Kingston, RI, ²Nephrology, Rhode Island Hsopital, Providence, RI, ³Pathology, Rhode Island Hospital, Providence, RI, ⁴Surgery, Rhode Island Hospital, Providence, RI, ⁵Organ Transplantation, Rhode Island Hospital, Brown University, KINGSTON, RI
*Purpose: Kidney transplantation (KTx) is the optimal treatment for end-stage renal diseases. The surgical procedure of KTx inherently requires cold ischemic preservation and warm reperfusion…
2018 American Transplant Congress
Extra-Renal Effects of Estrogen Receptor-Alpha Mediate Protection from Renal Ischemia-Reperfusion Injury
D. Aufhauser, D. Murken,¹ S. Concors,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology, University of Pennsylvania, Philadelphia, PA.
Introduction: Females exhibit protection from renal ischemia-reperfusion injury (IRI) compared to males in animal models and in human kidneys transplants. Previous experiments have shown that…
2018 American Transplant Congress
Endothelial Progenitor Cell-Derived Extracellular Vesicles Inhibit Kidney Ischemia-Reperfusion Injury through the Transfer of Specific microRNA and mRNA Coding for the Complement Inhibitors CD55, CD59, Factor H and for the Transcription Factor NRF2: Relevance for Delayed Kidney Graft Function
V. Cantaluppi,¹ D. Medica,¹ S. Dellepiane,¹ G. Merlotti,¹ A. Airoldi,¹ M. Quaglia,¹ G. Castellano,² L. Gesualdo,² G. Camussi.³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy; ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Bari, Bari, Italy; ³Department of Medical Sciences, University of Torino, Torino, Italy.
Complement activation and oxidative cell damage are hallmarks of delayed kidney graft function (DGF) due to ischemia-reperfusion injury (IRI). Endothelial progenitor cells (EPC) protect from…
2018 American Transplant Congress
Human Urine-Derived Stem Cells Protect Renal Function by Releasing miR-129-5p Which Targets High-Mobility Group Box-1 (HMGB1) in Rat Ischemia Reperfusion Injury Model
L. Liu, X. Li, Q. Su, Z. Bi, H. Huang, C. Wang.
Organ Transplant Center, The First Affiliated Hospital of Sun Yet-sen University, New York, NY, China.
Objective: This study investigated the protective effect of human urine-derived stem cells (USCs) on renal ischemia reperfusion injury (IRI) in rats. Methods: Human USCs was…
2017 American Transplant Congress
Signal Inhibitory Regulatory Protein-α Regulates Pathologic Reactive Oxygen Species in Acute Kidney Injury.
N. Rogers,^1,2,3 D. Meijles,³ P. Pagano,³ J. Isenberg.³
¹Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, NSW, Australia; ²Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA; ³Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
Background: Ischemia reperfusion injury (IRI) is mediated by a complex cascade of pro-inflammatory and oxidative processes. We have reported that signal regulatory inhibitory protein (SIRP)-α…
2017 American Transplant Congress
Renoprotective Effects of Carbon Monoxide–Releasing Molecule 3 in Ischemia Reperfusion Injury and Cisplatin-Induced Toxicity.
Y. Yoon,¹ H. Lee,¹ K. Huh,² M. Kim,² S. Kim,² Y. Kim,² W. Han.¹
¹Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; ²Transplantation Surgery, Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea
Background: We investigated the effects of a soluble carbon monoxide–releasing molecule (CORM) in cisplatin-induced cytotoxicity and ischemia reperfusion injury (IRI) in vitro.Methods: The effects of…
2017 American Transplant Congress
Accumulating Mitochondrial DNA in Aging Augments Inflammatory Responses Subsequent to IRI.
M. Seyda,^1,2 M. Quante,¹ T. Heinbokel,¹ G. Liu,¹ H. Uehara,¹ J. Schuitenmaker,¹ R. Abdi,³ C. Falk,² A. Elkhal,¹ S. Tullius.¹
¹Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany; ³Renal Division, Schuster Family Transplant Center, Brigham and Women's Hospital, Boston
Background: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns…
2017 American Transplant Congress
Intravoxel Incoherent Motion MRI Is an Effective Way to Monitor Acute Allograft Rejection in Rat Models.
S. Zeng, X. Hu.
Urology, Chao-Yang Hospital, Beijing, China
Objectives: To combine the intravoxel incoherent motion MRI and blood oxygen level-dependent MRI for assessment of the renal allograft pathological process undergoing acute rejection and…
2017 American Transplant Congress
How to Promote Regeneration After Ischemic Reperfusion Injury: Dual Role of CD 137 Agonistic Antibody.
J. Lee,^1,3 H. Kim,³ H. Chung,¹ K. Park,¹ B. Kwon,^3,4 H. Cho.^2,3
¹Internal Medicine, Ulsan University Hospital and College of Medicine, University of Ulsan, Ulsan, Korea; ²Surgery, Ulsan University Hospital and College of Medicine, University, Ulsan, Korea; ³Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea; ⁴School of Biological Science, University of Ulsan, Ulsan, Korea
Acute sterile inflammation can be induced by tissue damage caused by ischemia-reperfusion. In transplantation ischemia reperfusion injury (IRI) is unavoidable procedure. IRI causes delayed graft…
2017 American Transplant Congress
Nafamostat Mesilate Ameliorates Ischemia-Reperfusion Renal Injury via Anti-Apoptotic Mechanism.
D. Choi,¹ J. Jeong,² H. Bae,¹ Y. Ham,¹ K. Lee,¹ K. Na.¹
¹Chungnam National University, Nephrology, Daejeon, Korea; ²Chungnam National University, Department of Medical Science, Daejeon, Korea
Purpose: It has been reported that nafamostat mesilate inhibits inflammatory injury via inhibition of complement activation in ischemic heart, liver, and intestine. However, it is…