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American Transplant Congress abstracts

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Articles tagged "Renal ischemia"

  • 2022 American Transplant Congress

    Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts

    X. Lai1, J. Wang1, S. Han1, C. Chunlei1, L. VanOsdol1, L. Gallon2, J. Leventhal2, M. Kandpal1, Z. Zhang1

    1Comprehensive Transplant Center, Microsurgery core, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: We have previously demonstrated that donor kidney-intrinsic innate immunity determines the severity of delayed graft function (DGF) in kidney transplantation and potentiates long kidney…
  • 2022 American Transplant Congress

    Modification of Gut Microbiota Accelerates Kidney Repair After Experimental Ischemia Reperfusion Injury

    S. Gharaie, K. Lee, S. Noel, L. Arend, H. Rabb

    Johns Hopkins Medicine, Baltimore, MD

    *Purpose: Kidney ischemia reperfusion injury (IRI) leads to changes in gut microbiome, and pre-IR microbiome changes can modify course of experimental tissue injury. There is…
  • 2022 American Transplant Congress

    QSant, a Novel Urine Test Monitors Recovery of Allograft Injury After DGF

    S. Ghosh1, H. Tedesco2, R. Sarwal1, N. Titzler1, W. Yazar1, M. Nakamura2, J. Pestana2, M. Sarwal1

    1Nephrosant, Brisbane, CA, 2Hospital do Rim, Sao Paolo, Brazil

    *Purpose: We evaluate urine QSant assay to non-invasively monitor recovery of allograft injury, post delayed graft function(DGF).*Methods: 65 HLA-DR matched, renal allograft recipients, on TAC/MMF/prednisone…
  • 2022 American Transplant Congress

    Apoptotic Exosome-Like Vesicles Aggravate Inflammation and Renal Injury After Ischemia-Reperfusion

    I. Kaci1, S. Lan1, H. Kim1, A. Karakeussian Rimbaud1, F. Migneault1, J. Turgeon1, N. Patey2, M. Dieudé1, M. Hébert1

    1Research Centre, Centre hospitalier de l’Université de Montréal, Montreal, QC, Canada, 2Research Centre, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and chronic kidney disease (CKD). Damage to microvascular peritubular capillaries (PTC) is…
  • 2021 American Transplant Congress

    Mapping Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) in Kidney Transplant Biopsies Reveals Two Classes of Early AKI That Differ in Their Response-to-Wounding

    P. Halloran1, J. Reeve1, G. Böhmig2, O. Viklicky3, M. Myslak4, G. Gupta5, &. the INTERCOMEX Study Group6

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2Medical University of Vienna, Vienna, Austria, 3Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 4Pomeranian Medical University, Szczecin, Poland, 5Virginia Commonwealth University, Richmond, VA, 6., ., AB, Canada

    *Purpose: We recently analyzed injury-induced molecular changes in kidney transplant biopsies using principal component analysis (PCA) (AJT https://doi.org/10.1111/ajt.16374). PC1 reflected all injury, PC2 distinguished early…
  • 2021 American Transplant Congress

    Estrogen Receptor Beta Deletion is Protective in Renal Ischemia Reperfusion Injury in a Renal Specific Manner

    C. S. O'Brien, P. Hernandez, Z. Wang, G. Ge, W. Hancock, M. H. Levine

    Surgery, University of Pennsylvania, Philadelphia, PA

    *Purpose: Renal Ischemia Reperfusion Injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. Previously, we have shown lower rates of…
  • 2021 American Transplant Congress

    Patterns and Inhibition of Cell Death During Static Cold Storage of Human Kidneys

    J. R. DiRito1, G. Chickering2, J. T. Langford1, D. Stern1, S. Hosgood3, M. L. Nicholson3, E. Gavathiotis4, R. N. Kitsis5, M. Saltzman2, J. S. Pober6, G. T. Tietjen7

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale University, New Haven, CT, 3Surgery, University of Cambridge, Cambridge, United Kingdom, 4Biochemistry and Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY, 5Surgery, Albert Einstein College of Medicine, Bronx, NY, 6Immunobiology, Yale University, New Haven, CT, 7Surgery and Biomedical Engineering, Yale School of Medicine, New Haven, CT

    *Purpose: As the donor population continues to age and accumulate co-morbidities, more marginal kidneys are being retrieved for transplantation. However, estimates suggest that more than…
  • 2021 American Transplant Congress

    Sigma-1 Receptor Agonists are Renoprotective in Experimental Kidney Transplantation

    A. Hosszu1, T. Lakat1, A. Toth1, D. Balogh1, J. Hodrea1, L. J. Wagner2, A. J. Szabo1, A. Fekete1

    11st Department of Pediatrics, Semmelweis University, Budapest, Hungary, 2Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

    *Purpose: Kidney transplantation (Tx) is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a…
  • 2021 American Transplant Congress

    Effect of Defibrotide on Kidney Ischemia Reperfusion Injury in a Preclinical Renal Transplant Model

    P. Pine1, Z. Sun2, A. Matas3, J. Shi1, A. Ebrahimnejad1, M. Zanette4, P. Halloran5, J. S. Bromberg6, R. Hanvesakul7

    1Jazz Pharmaceuticals, Palo Alto, CA, 2Johns Hopkins Medicine, Baltimore, MD, 3Univ of Minnesota, Minneapolis, MN, 4Jazz Pharmaceuticals, Philadelphia, PA, 5Univ of Alberta, Edmonton, AB, Canada, 6Univ of Maryland School of Medicine, Baltimore, MD, 7Jazz Pharmaceuticals, Oxford, United Kingdom

    *Purpose: Ischemia reperfusion injury (IRI) is a major contributor to graft failure. During organ removal and preservation, ischemia results in anaerobic respiration and cellular damage.…
  • 2021 American Transplant Congress

    Not Quite Right: The Irony of Longer Cold Times for Higher KDPI Kidneys

    H. Ghali1, D. Won1, S. Yoon1, A. Friedman2

    1Systems Science and Industrial Engineering, SUNY Binghamton, Binghamton, NY, 2LiveOnNY, New York, NY

    *Purpose: To identify tactics for reduction of the kidney discard rate, we analyzed measurable, operational factors contributing to the key outcome of transplantation (TXP) or…
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